Month: December 2022

Tian, Ze-Yu published the artcileVisible-light-initiated catalyst-free trifluoromethylselenolation of arylsulfonium salts with [Me₄N][SeCF₃], SDS of cas: 637-07-0, the publication is Organic Chemistry Frontiers (2022), 9(8), 2220-2227, database is CAplus.

The redox potential gap between arylsulfonium salts and [Me₄N][SeCF₃] has been clearly revealed by CV measurements. Construction of the carbon-selenium bond by overcoming this gap without using catalysts and additives is a challenging task. Here, the authors report an efficient visible-light-induced cross-coupling of arylsulfonium triflates, e.g., 5-[4-(4-cyanophenoxy)phenyl]-5H-thianthren-5-ium triflate, with [Me₄N][SeCF₃] by simply mixing these two species, which allowed the facile synthesis of various aryl trifluoromethyl selenoethers, e.g., ArSeCF₃ (Ar = 2-formyl-4-methoxyphenyl, N-methylcarbazol-6-yl, benzodioxol-5-yl, etc.) under catalyst- and additive-free conditions. The mechanistic study indicated that aryl and SeCF₃ radicals might be formed as key intermediates in the reactions. Merits of the reactions include operational simplicity, high efficiency, visible-light irradiation, good functional group tolerance, a wide range of substrates, excellent chemoselectivity, and good yields of (trifluoromethyl)selenolated products, which combined with a sulfenylation process enabled the selective and practical installation of SeCF₃ moieties onto complex arenes, including drug mols., via a formal C-H functionalization.

Organic Chemistry Frontiers published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C7H8O3, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileSynthesis and Properties of Photochromic Diarylethene Containing N-Salicylideneaniline Units, SDS of cas: 219537-97-0, the publication is Molecular Crystals and Liquid Crystals (2012), 557(1), 84-89, database is CAplus.

A sym. diarylethene containing N-salicylideneaniline (Schiff base) units was synthesized. The structure was well confirmed by NMR spectroscopy, mass spectrometry, and elemental anal. Its photochromism was investigated by UV/visible absorption spectra and NMR. The result displayed that diarylethene can well perform photoisomerization, but no obvious intramol. proton transfer was observed Furthermore, we checked the effects of metal cations for the properties of N-salicylideneaniline-based diarylethene, which indicated that Cu²⁺ and Fe³⁺ cations can significantly affect the UV/visible absorption spectra of diarylethene ring-open and ring-closed isomers.

Molecular Crystals and Liquid Crystals published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, SDS of cas: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Xuelian published the artcileSynthesis and biological evaluation of isatin derivatives containing 1,3,4-thiadiazole as potent a-glucosidase inhibitors, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2021), 128447, database is CAplus and MEDLINE.

A series of isatin derivatives containing 1,3,4-thiadiazole derivatives I [R = 2-F, 3-CN, 4-Cl, etc.] were designed and synthesized. All newly synthesized compounds I were evaluated for their α-glucosidase inhibitory activity with resveratrol as pos. control in-vitro. Except for compounds I [R = 2-CN, 3-CN], all of the compounds I showed a potent inhibitory activity against α-glucosidase with IC₅₀ values in the range of 3.12 ± 1.25 to 45.95 ± 1.26μM and the purity of these compounds were greater than 95%. The IC₅₀ values were being compared to the standard resveratrol (IC₅₀ = 22.00 ± 1.15μM) and it was found that compounds I [R = H, 2-F, 2-Cl, 3-Cl, 4-Cl, 2-Br] were found to be more active than resveratrol. Specifically,I [R = 4-Cl] exhibited the most potent α-glucosidase inhibitory activity with IC₅₀ value of 3.12 ± 1.25μM. The kinetic anal. revealed that compound I [R = 4-Cl] was noncompetitive inhibitor. Structure activity relationship was established for all compounds I. Furthermore, the binding interactions of compound I [R = 4-Cl] with the active site of α-glucosidase were confirmed through mol. docking. This study was identified a new class of potent α-glucosidase inhibitors for further investigation.

Bioorganic & Medicinal Chemistry Letters published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C24H20Ge, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dong, Xiao-Yang published the artcileCopper-Catalyzed Asymmetric Coupling of Allenyl Radicals with Terminal Alkynes to Access Tetrasubstituted Allenes, Computed Properties of 866-23-9, the publication is Angewandte Chemie, International Edition (2021), 60(4), 2160-2164, database is CAplus and MEDLINE.

In contrast to the wealth of asym. transformations for generating central chirality from alkyl radicals, the enantiocontrol over the allenyl radicals for forging axial chirality represents an uncharted domain. The challenge arises from the unique elongated linear configuration of the allenyl radicals that necessitates the stereo-differentiation of remote motifs away from the radical reaction site. We herein describe a copper-catalyzed asym. radical 1,4-carboalkynylation of 1,3-enynes via the coupling of allenyl radicals with terminal alkynes, providing diverse synthetically challenging tetrasubstituted chiral allenes. A chiral N,N,P-ligand is crucial for both the reaction initiation and the enantiocontrol over the highly reactive allenyl radicals. The reaction features a broad substrate scope, covering a variety of (hetero)aryl and alkyl alkynes and 1,3-enynes as well as radical precursors with excellent functional group tolerance.

Angewandte Chemie, International Edition published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yu, Wei published the artcileSynthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety, HPLC of Formula: 620-20-2, the publication is Research on Chemical Intermediates (2019), 45(12), 5989-6001, database is CAplus.

Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring I (R = cyano, 3,4-dichlorophenyl, 2-chlorothiazol-5-yl, etc.) were designed and synthesized from Et acetoacetate and tri-Et orthoformate as starting materials via multi-step reactions. They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate-to-good activity as a herbicide.

Research on Chemical Intermediates published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C8H8O2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Surnin, V. A. published the artcileAminoalkylation of hydrazine by 2-halopropylamine hydrohalides, SDS of cas: 4584-49-0, the publication is Zhurnal Organicheskoi Khimii (1983), 19(11), 2288-94, database is CAplus.

MeCHXCH₂NRR¹.HX¹ (I; X = OH; R = H, R¹ = H, Me, Me₃C, Ph; R = R¹ = Me; X¹ = Br) reacted with PBr₃ or SOCl₂ to give 6 corresponding I (X = X¹ = Br, Cl) (II) in 31-90% yield. II reacted with N₂H₄.H₂O in MeOH to give mixtures of 5 corresponding H₂NNHCHMeCH₂NRR¹ (III) and RR¹NCHMeCH₂NHNH₂ (IV) with the latter predominating, indicating an aziridinium salt intermediate. All 10 III and IV condensed with 1 equivalent Me₂CO in C₆H₆ to give the corresponding Me₂C:NNHCHMeCH₂NRR¹ and RR¹NCHMeCH₂NHN:CMe₂, resp. Treating III (R = R¹ = H) and IV (R = R¹ = H) with excess refluxing Me₂CO containing potash gave 40% iminoimidazolidines V (Z = CHMeCH₂, CH₂CHMe).

Zhurnal Organicheskoi Khimii published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H10Cl3O3P, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun published the artcileA new insight into the push-pull effect of substituents via the stilbene-like model compounds, Formula: C8H6ClF3, the publication is Journal of Physical Organic Chemistry (2022), 35(4), e4319, database is CAplus.

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via using the NMR chem. shift of bridging bond carbon atoms. It is demonstrated that the maximum push-pull effect is not always between the strong electron-donating D and strong electron-accepting A groups in D-π-A compounds The action mode of push-pull effect of substituents in D-π-A compounds is dominated by their mol. parent structure. The contribution of field/inductive effect and conjugative effect of a group to the push-pull effect is unequal. When the D-π-A parent mol. is in a plane, the influence of field/inductive effect of a group on the push-pull effect is greater than or close to that of its conjugative effect does. Although the parent mol. is sterically twisted, the push-pull effect is mainly dependent on the conjugative effect of a group. The results of this paper can provide us a new insight into the push-pull effect of substituents.

Journal of Physical Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun published the artcileA new insight into the push-pull effect of substituents via the stilbene-like model compounds, HPLC of Formula: 620-20-2, the publication is Journal of Physical Organic Chemistry (2022), 35(4), e4319, database is CAplus.

In this paper, authors report on 1-pyridyl-2-arylethenes, 1-furyl-2-arylethylenes, 1,2-diphenylpropylenes and substituted cinnamyl anilines as stilbene-like model compounds to investigate the factors dominating the push-pull effect of substituents via using the NMR chem. shift of bridging bond carbon atoms. It is demonstrated that the maximum push-pull effect is not always between the strong electron-donating D and strong electron-accepting A groups in D-π-A compounds The action mode of push-pull effect of substituents in D-π-A compounds is dominated by their mol. parent structure. The contribution of field/inductive effect and conjugative effect of a group to the push-pull effect is unequal. When the D-π-A parent mol. is in a plane, the influence of field/inductive effect of a group on the push-pull effect is greater than or close to that of its conjugative effect does. Although the parent mol. is sterically twisted, the push-pull effect is mainly dependent on the conjugative effect of a group. The results of this paper can provide us a new insight into the push-pull effect of substituents.

Journal of Physical Organic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, HPLC of Formula: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Bin-bin published the artcileSynthesis of N-alkyl-carbazole-3, 6-dicarbaldehyde, Application In Synthesis of 23616-79-7, the publication is Huaxue Shiji (2013), 35(7), 589-592, database is CAplus.

Using benzyltributylammonium chloride as phase transfer catalyst and 50% NaOH aqueous solution as acid binding agent, carbazole reacted with alkyl halides in mole ratio 1:1.2 at reflux in benzene for 3∼4 h to produce alkylcarbazoles. Then the resulting alkylcarbazoles reacted with fourfold equivalent freshly distilled DMF and POCl₃ in chlorobenzene to obtain the title compounds Structures of the products were confirmed by ¹HNMR and IR.

Huaxue Shiji published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Application In Synthesis of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jiang, Jun published the artcileSynthesis of N-arylsulfonamides via Fe-promoted reaction of sulfonyl halides with nitroarenes in an aqueous medium, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Organic & Biomolecular Chemistry (2018), 16(27), 5016-5020, database is CAplus and MEDLINE.

A fascinating Fe-promoted protocol for the synthesis of N-arylsulfonamides has been developed. Starting from com. available nitroarenes R¹NO₂ (R¹ = Ph, 2-ClC₆H₄, 4-HOC₆H₄, 1,2,4-triazol-3-yl, etc.) and sulfonyl chlorides R²SO₂Cl (R² = Me, Ph, 3-BrC₆H₄, 2-naphthyl, 2-thienyl, etc.), moderate to excellent yields of the corresponding N-arylsulfonamides R¹NHSO₂R² can be obtained. In particular, Fe dust serves as the sole reductant in the transformation and it can be easily performed on a large scale.

Organic & Biomolecular Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics