Month: December 2022

Photolysis of ortho-nitrobenzylic derivatives: the importance of the leaving group was written by Solomek, Tomas;Mercier, Sebastien;Bally, Thomas;Bochet, Christian G.. And the article was included in Photochemical & Photobiological Sciences in 2012.HPLC of Formula: 57045-82-6 This article mentions the following:

Quantum yields for the photoinduced release of seven different commonly used leaving groups (LGs) from the o-nitroveratryl protecting group were measured. It was found that these quantum yields depend strongly on the nature of the LGs. The authors show that the quantum efficiency with which the LGs are released correlates with the stabilization that these LGs provide to o-nitrobenzyl-type radicals because radical stabilizing groups weaken the C-H bond that is cleaved in the photoinduced hydrogen atom transfer step, and hence lower the barrier for this process. At the same time these substituents lower the endothermicity of the thermal hydrogen atom transfer and thus increase the barrier for the reverse process, thereby enhancing the part of the initially formed aci-nitro intermediates which undergo cyclization (which ultimately leads to LG release). Radical stabilization energies computed by DFT methods are thus a useful predictor of the relative efficiency with which LGs are photoreleased from o-nitrobenzyl protecting groups. In the experiment, the researchers used many compounds, for example, Chloroformicacidn-nonylester (cas: 57045-82-6HPLC of Formula: 57045-82-6).

Chloroformicacidn-nonylester (cas: 57045-82-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 57045-82-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Antihyperglycemic and Antihyperlipidemic Effects of Newly Synthesized Glibenclamide Analogues on Streptozotocin-diabetic Rats was written by Ahmadi, A.;Khalili, M.;Farsadrooh, M.;Ghiasi, M.;Nahri-Niknafs, B.. And the article was included in Drug Research (Stuttgart, Germany) in 2013.Formula: C8H7ClO3 This article mentions the following:

In this study, new glibenclamide analogs (5a-d) with substituted pharmacol. triethoxysilyl propan, allyl and ethoxyphenyl groups for cyclohexyl moiety have been synthesized by condensing sulfonamide (4) with related isocyanate or isothiocyanate’s compounds The newly synthesized drugs were evaluated for their antihyperglycemic and antihyperlipidemic activities with streptozotocin (STZ)-induced diabetic rats. All showed hypoglycemic and hypolipidemic activities compared to the control animals but 5c and 5d exhibited more and significant lowering blood activities similar to glibenclamide. This was concerned with identical affinities to bind with SUR1 receptor. Moreover, the new drugs displayed high efficiency for reducing serum LDL level which resulted in a high HDL/LDL ratio as a good lipid profile compared to other groups. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Formula: C8H7ClO3).

5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Formula: C8H7ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and photocatalytic properties of nanostructured lanthanide doped β-NaYF₄/TiO₂ composite films was written by Pennisi, Fabiana M.;Pellegrino, Anna L.;Licciardello, Nadia;Mezzalira, Claudia;Sgarzi, Massimo;Speghini, Adolfo;Malandrino, Graziella;Cuniberti, Gianaurelio. And the article was included in Scientific Reports in 2022.Synthetic Route of C16H18ClN3S This article mentions the following:

The photocatalytic approach is known to be one of the most promising advanced oxidation processes for the tertiary treatment of polluted water. In this paper, β-NaYF₄/TiO₂ composite films have been synthesized through a novel sol-gel/spin-coating approach using a mixture of β-diketonate complexes of Na and Y, and Yb³⁺, Tm³⁺, Gd³⁺, Eu³⁺ as doping ions, together with the TiO₂ P25 nanoparticles. The herein pioneering approach represents an easy, straightforward and industrially appealing method for the fabrication of doped β-NaYF₄/TiO₂ composites. The effect of the doped β-NaYF₄ phase on the photocatalytic activity of TiO₂ for the degradation of methylene blue (MB) has been deeply investigated. In particular, the upconverting TiO₂/β-NaYF₄: 20%Yb, 2% Gd, x% Tm (x = 0.5 and 1%) and the downshifting TiO₂/β-NaYF₄: 10% Eu composite films have been tested on MB degradation both under UV and visible light irradiation An improvement up to 42.4% in the degradation of MB has been observed for the TiO₂/β-NaYF₄: 10% Eu system after 240 min of UV irradiation In the experiment, the researchers used many compounds, for example, 3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4Synthetic Route of C16H18ClN3S).

3,7-Bis(dimethylamino)phenothiazin-5-ium chloride (cas: 61-73-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C16H18ClN3S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate was written by Saunthwal, Rakesh K.;Patel, Monika;Tiwari, Rakesh K.;Parang, Keykavous;Verma, Akhilesh K.. And the article was included in Green Chemistry in 2015.Formula: C7H3Cl2NS This article mentions the following:

A green and catalyst-free atom-economic straightforward tandem approach for the synthesis of highly functionalized tetrahydroquinazolines by the reaction of 2-aminophenylacrylates with isothiocyanates using water as an environmentally friendly solvent via amidation and concomitant chemoselective Michael addition is described. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Formula: C7H3Cl2NS).

2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C7H3Cl2NS

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Pore size regulation of polyamide composite membrane via a sol-gel process confined within the selective layer was written by He, Qingyuan;Hu, Yifei;Li, Xingzheng;Liu, Meihong;Yu, Sanchuan;Gao, Congjie. And the article was included in Journal of Membrane Science in 2022.Product Details of 4422-95-1 This article mentions the following:

Membrane with pores of homogeneous size distribution is vital to high fraction efficiency of nanofiltration process. In this study, a novel approach of space-confined sol-gel was put forward to regulate the size and distribution of the pores of interfacially synthesized polyamide composite membrane for enhanced fraction efficiency. Tetra-Et orthosilicate (TEOS) was introduced into the porous polyamide network of the selective layer and employed to in situ generate a new silica network through space-confined hydrolysis and condensation. Membrane property including pore size distribution and separation performance was tuned by regulating the content of TEOS and systematically characterized by ATR-FTIR, XPS, SEM, AFM and cross-flow permeation test. The sol-gel of TEOS mols. confined within the selective layer was found to form a new polyamide-silica based separation layer with decreased pore size and homogenized pore size distribution. The mean size in diameter and geometric standard deviation of size distribution of the pores of the virgin polyamide based membrane were about 0.64 nm and 1.32, while those of the desired polyamide-silica based membrane obtained with a TEOS content of 3.0 volume/volume% were 0.59 nm and 1.26, resp. The glucose rejection increased significantly from 58.0% of virgin polyamide membrane to 81.5% of the desired polyamide-silica based membrane. Permeation tests with concentrated mixed solution also revealed that, the desired polyamide-silica based membrane possessed better efficiency in the removal of sodium sulfate from the concentrated brine compared to the com. membrane NF270, showing an average Na₂SO₄ rejection above 98.3%, a water flux around 120.0 l/m² h, and nearly no NaCl rejection to a concentrated brine containing 200.0 g/L NaCl and 10.0 g/L Na₂SO₄ under 30.0 bar and 40.0°C. In the experiment, the researchers used many compounds, for example, Trimesoylchloride (cas: 4422-95-1Product Details of 4422-95-1).

Trimesoylchloride (cas: 4422-95-1) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Product Details of 4422-95-1

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

High Proportion of Chiral Crystallization of Achiral Indolyl Sulfonamides: Effect of Intermolecular Interactions was written by Kikkawa, Shoko;Maeno, Isae;Katagiri, Kosuke;Murayama, Yuta;Nozawa, Mariko;Hikawa, Hidemasa;Azumaya, Isao. And the article was included in Crystal Growth & Design in 2021.Application of 777-44-6 This article mentions the following:

We investigated the effect of indole moieties on chiral crystallization In this regard, we assessed the influence of intermol. interactions and contacts on the assembly of these mols. A systematic anal. of 62 crystal structures of secondary aromatic sulfonamides bearing 4-, 5-, 6-, and 7-aminoindolyl groups revealed that the proportion of indolyl compounds showing chiral crystallization was apparently higher (21%, except for crypto-racemate) than that of nonindolyl sulfonamides (11%). Moreover, 33% (5 out of 15 crystals) and 44% (7 out of 16 crystals) of 4- and 7-indolyl sulfonamide derivatives preferred chiral crystallization, resp. This suggested a correlation between the type of contact and the chirality of the assembly of adjacent mols. Specifically, the proportion of achiral indolyl sulfonamides undergoing chiral crystallization was drastically increased by N(indole)H···O interactions, slightly increased by C(sp²)H···π interactions, and decreased owing to π···π interactions. These tendencies were also true for sulfonamides with different substituents, which suggested that the T-shape contact would be more favorable than π···π interactions for chiral crystallization In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Application of 777-44-6).

3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 777-44-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and Antimicrobial Evaluation of Calycanthaceous Alkaloid Derivatives was written by Yang, Cheng;Zheng, Shaojun;Tan, Yi;Chen, Xiaoyun;Bai, Hongjin;Zhu, Rui;Gao, Yuhua. And the article was included in Chemistry of Natural Compounds in 2021.Safety of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:

To find pesticidal lead compounds with high activity, a series of new chimonanthine derivatives was synthesized via the introduction of the functional group at the N-position to compound I. A preliminary bioassay showed that most of them displayed potent bioactivities. In particular, compound II displayed significant activity and might be a potential novel lead compound for further development of antifungal agent. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Safety of 1-(Chloromethyl)-3-methylbenzene).

1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Safety of 1-(Chloromethyl)-3-methylbenzene

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Suzuki-Miyaura Cross-Coupling of Potassium Dioxolanylethyltrifluoroborate and Aryl/Heteroaryl Chlorides was written by Fleury-Bregeot, Nicolas;Oehlrich, Daniel;Rombouts, Frederik;Molander, Gary A.. And the article was included in Organic Letters in 2013.HPLC of Formula: 18437-66-6 This article mentions the following:

A robust and efficient protocol for the introduction of the dioxolanylethyl moiety onto various aryl and heteroaryl halides has been developed, providing cross-coupling yields up to 93%. Copper-catalyzed borylation of 2-(2-bromoethyl)-1,3-dioxolane with bis(pinacolato)diboron followed by treatment with potassium bifluoride provides the key organotrifluoroborate reagent. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6HPLC of Formula: 18437-66-6).

tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.HPLC of Formula: 18437-66-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

AI-PCSAFT approach: New high predictive method for estimating PC-SAFT pure component properties and phase equilibria parameters was written by Abdallah el hadj, A.;Laidi, M.;Hanini, S.. And the article was included in Fluid Phase Equilibria in 2022.Formula: C19H15Cl This article mentions the following:

In this work, a new approach based on the association of Artificial intelligence method (AI) and PC-SAFT equation of state is applied to conceive a model for estimating the solubility of solid drugs in supercritical carbon dioxide. Neuro-equation of state approach (NES) is the new technique that takes benefit from the advantages of both ANN and PC-SAFT equation of state. The new method decomposes into three main stages, first the optimization of direct ANN for predicting solids-scCO₂ phase equilibrium (where 15 binary systems are used), then the ANN inverse is performed to be an alternative to group contribution methods (GCMs) for estimating the pure components and phys. properties (reduce the uncertainty committed in estimating these properties) and enhance the PCSAFT equation of state to estimate phase equilibrium parameters and finally, ANN-PCSAFT approach is used to estimate the solubility of 213 solid solutes in supercritical carbon dioxide. The performance strategy has been carried out using a linear regression anal. of the predicted vs. exptl. outputs, as an indication of the predictive ability of the developed method. The new approach is successfully applied to the phase equilibrium modeling for 213 binary systems with high accuracy (the comparison in terms of average absolute relative deviation (AARD %) showed a variation from 2 to 6%) and allowed to enhance the phase equilibrium modeling by reducing the number of optimized parameters and surpass the main drawbacks faced in this area mainly the non-availability of phys. properties and EOS pure component properties and the limitation of the equation of state. In the experiment, the researchers used many compounds, for example, (Chloromethanetriyl)tribenzene (cas: 76-83-5Formula: C19H15Cl).

(Chloromethanetriyl)tribenzene (cas: 76-83-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Formula: C19H15Cl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Comparison on the compositions of essential oils from the seed and pulp of Schisandra sphenanthera Rehd. et Wils. was written by Wang, Xiaorui;Liu, Yan;Zhou, Shichao;Qin, Xiaolu;Gu, Wei. And the article was included in Journal of Essential Oil-Bearing Plants in 2017.Recommanded Product: 3386-33-2 This article mentions the following:

Schisandra sphenanthera Rehd. et Wils. belongs to the Schisandra family and its fruits are known to be the effective parts in Traditional Chinese Medicine (TCM). The chem. compositions of the essential oils from different parts of fruits of S. sphenanthera isolated by hydrodistillation extraction were analyzed by GC-MS. The extraction yield percentage of the essential oils from the seed and pulp were 2.82% and 0.65% (% dry weight, v/w), resp. The color of the essential oils from the seed were ivory-white and yellowish for pulp, resp. A total of sixty compounds were identified and there were 15 mutual compounds existed in two different parts. Although the majority of these compounds (more than 65%) belonged to sesquiterpenes and oxygenated sesquiterpenes. The differences between seed and pulp were readily observed: ketones were only found in seed, and aldehyde, halogenated hydrocarbons, olefin hydrocarbons, acids and alcs. were only found in pulp. In the experiment, the researchers used many compounds, for example, 1-Chlorooctadecane (cas: 3386-33-2Recommanded Product: 3386-33-2).

1-Chlorooctadecane (cas: 3386-33-2) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 3386-33-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics