Month: December 2022

Hou, Lili published the artcileReversible Photochemical Control of Singlet Oxygen Generation Using Diarylethene Photochromic Switches, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of the American Chemical Society (2014), 136(3), 910-913, database is CAplus and MEDLINE.

Reversible noninvasive control over the generation of singlet oxygen is demonstrated in a bicomponent system comprising a diarylethene photochromic switch and a porphyrin photosensitizer by selective irradiation at distinct wavelengths. The efficient generation of singlet oxygen by the photosensitizer is observed when the diarylethene unit is in the colorless open form. Singlet oxygen generation is not observed when the diarylethene is converted to the closed form. Irradiation of the closed form with visible light (>470 nm) leads to full recovery of the singlet oxygen generating ability of the porphyrin sensitizer.

Journal of the American Chemical Society published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Safety of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Dingzhong published the artcileFeO(OH)@C-Catalyzed Selective Hydrazine Substitution of p-Nitro-Aryl Fluorides and their Application for the Synthesis of Phthalazinones, COA of Formula: C6H3ClFNO2, the publication is ChemistryOpen (2022), 11(5), e202200023, database is CAplus and MEDLINE.

An efficient hydrazine substitution of p-nitro-aryl fluorides viz., 2-chloro-1-fluoro-4-nitrobenzene, 2-bromo-1-fluoro-4-nitrobenzene, 2-fluoro-5-nitroaniline, etc. with hydrazine hydrates catalyzed by FeO(OH)@C nanoparticles is described. These hydrazine substitutions of p-nitro-aryl fluorides bearing electron-withdrawing groups such as 2-chloro-1-fluoro-4-nitrobenzene, 2-bromo-1-fluoro-4-nitrobenzene, 1-bromo-2,4-difluoro-5-nitrobenzene, etc. proceeded efficiently with high yield and selectivity. Similarly, hydrogenations of p-nitro-aryl fluorides containing electron-donating groups such as 2-fluoro-5-nitroaniline, 1-fluoro-2-methyl-4-nitrobenzene, 2-bromo-4-fluoro-1-nitrobenzene, etc. also smoothly proceeded under mild conditions. Furthermore, with these prepared aryl hydrazines viz., (2-chloro-4-nitrophenyl)hydrazine, (3-fluoro-4-nitrophenyl)hydrazine, (2-bromo-4-nitrophenyl)hydrazine, (2,3-difluoro-4-nitrophenyl)hydrazine, (2-chloro-3-fluoro-4-nitrophenyl)hydrazine, some phthalazinones I (R = H, 4-hydroxyphenyl; R¹ = 2-Cl, 2-Br, 3-F, 2-Cl-3-F, 2,3-F₂), interesting as potential structures for pharmaceuticals, have been successfully synthesized in high yields.

ChemistryOpen published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, COA of Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sun, Guo-Quan published the artcileNickel-catalyzed electrochemical carboxylation of unactivated aryl and alkyl halides with CO₂, Application In Synthesis of 637-07-0, the publication is Nature Communications (2021), 12(1), 7086, database is CAplus and MEDLINE.

A general and practical electro-reductive Ni-catalytic system, realizing the electrocatalytic carboxylation of unactivated aryl chlorides and alkyl bromides with CO₂ were reported. A variety of unactivated aryl bromides, iodides and sulfonates can also undergo such a reaction smoothly. Notably, realized the catalytic electrochem. carboxylation of aryl (pseudo)halides with CO₂ avoiding the use of sacrificial electrodes. Moreover, this sustainable and economic strategy with electron as the clean reductant features mild conditions, inexpensive catalyst, safe and cheap electrodes, good functional group tolerance and broad substrate scope. Mechanistic investigations indicated that the reaction might proceed via oxidative addition of aryl halides to Ni(0) complex, the reduction of aryl-Ni(II) adduct to the Ni(I) species and following carboxylation with CO₂.

Nature Communications published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C40H35N7O8, Application In Synthesis of 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Xu-Jun published the artcileSynthesis and fungicidal activity of phenazine-1-carboxylic triazole derivatives, Computed Properties of 620-20-2, the publication is Journal of Asian Natural Products Research (2021), 23(5), 452-465, database is CAplus and MEDLINE.

A total of 15 novel-substituted 3-(benzylsulfanyl)-1H-1,2,4-triazol-5-ylamines I [R = 3-MeC₆H₄, 2-FC₆H₄, 2,4-Cl₂C₆H₃, etc.] and 10 novel-substituted 3-benzylmercapto-1,2,4-triazole derivatives II were synthesized based on the natural product phenazine-1-carboxylic acid (PCA). Their structures were confirmed by ¹H-NMR, ¹³C-NMR, HRMS and X-ray. Most substituted 3-benzylmercapto-1,2,4-triazole derivatives II displayed very strong fungicidal activity against one or multiple plant pathogens in vitro and in vivo. Compounds II [R = 4-MeC₆H₄, 4-iPrC₆H₄, 4-tBuC₆H₄, etc.] showed a broad spectrum of fungicidal activity. Further field experiments indicated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] displayed better efficacy against rice blast (Pyricularia oryzae) than PCA. These data demonstrated that compounds II [R = 4-MeC₆H₄, 2-FC₆H₄, 4-iPrC₆H₄, etc.] were promising fungicidal candidates, deserving further studies.

Journal of Asian Natural Products Research published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Computed Properties of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Jie-long published the artcileGreen synthesis of germicide Prochloraz, Category: chlorides-buliding-blocks, the publication is Huaxue Shiji (2010), 32(9), 856-858, database is CAplus.

Prochloraz is a broad-spectrum imidazole germicide. The synthesis of the target compound [i.e., N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide, Prochloraz, Mirage, Preclude, Sportake, etc.] was achieved using using 2,4,6-trichlorophenol, 1,2-ethanediol, imidazole and triphosgene as starting materials in an environmentally friendly synthetic sequence (green chem.).

Huaxue Shiji published new progress about 67747-01-7. 67747-01-7 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Amine,Benzene,Ether,Benzene Compounds, name is N-(2-(2,4,6-Trichlorophenoxy)ethyl)propan-1-amine, and the molecular formula is C4H7F3O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Feng published the artcileCatalytic and Photochemical Strategies to Stabilized Radicals Based on Anomeric Nucleophiles, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of the American Chemical Society (2020), 142(25), 11102-11113, database is CAplus and MEDLINE.

Carbohydrates, one of the three primary macromols. of living organisms, play significant roles in various biol. processes such as intercellular communication, cell recognition, and immune activity. While the majority of established methods for the installation of carbohydrates through the anomeric carbon rely on nucleophilic displacement, anomeric radicals represent an attractive alternative because of their functional group compatibility and high anomeric selectivities. Herein, we demonstrate that anomeric nucleophiles such as C1 stannanes can be converted into anomeric radicals by merging Cu(I)-catalysis with blue light irradiation to achieve highly stereoselective C(sp3)-S cross-coupling reactions. Mechanistic studies and DFT calculations revealed that the C-S bond-forming step occurs via the transfer of the anomeric radical directly to a sulfur electrophile bound to Cu(II) species. This pathway complements a radical chain observed for metal-free conditions where a disulfide initiator can be activated by a Lewis base additive. Both strategies utilize anomeric nucleophiles as efficient radical donors and achieve a switch from an ionic to a radical pathway. Taken together, the stability of glycosyl nucleophiles, a broad substrate scope, and high anomeric selectivities observed for the thermal and photochem. protocols make this novel C-S cross-coupling a practical tool for late-stage glyco-diversification of bioactive natural products and drug candidates.

Journal of the American Chemical Society published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C4H5BN2O2, Safety of 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yao, Qi-Jun published the artcileAtroposelective Synthesis of Axially Chiral Biaryls by Palladium-Catalyzed Asymmetric C-H Olefination Enabled by a Transient Chiral Auxiliary, Name: 4-Chloro-2-methylphenylboronic acid, the publication is Angewandte Chemie, International Edition (2017), 56(23), 6617-6621, database is CAplus and MEDLINE.

Atroposelective synthesis of axially chiral biaryls by palladium-catalyzed C-H olefination, using tert-leucine as an inexpensive, catalytic, and transient chiral auxiliary, has been realized. This strategy provides a highly efficient and straightforward access to a broad range of enantioenriched biaryls, e.g., I (X-rays single crystal structure shown), in good yields (up to 98 %) with excellent enantioselectivities (95 to >99 % ee). Kinetic resolution of trisubstituted biaryls bearing sterically more demanding substituents is also operative, thus furnishing the optically active olefinated products with excellent selectivity (95 to >99 % ee, s-factor up to 600).

Angewandte Chemie, International Edition published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C10H14O, Name: 4-Chloro-2-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yang, Hu published the artcileHydrosilylation of alkenes catalyzed by MCM-48 supported chitosan-platinum complex, Formula: C9H20Cl2Si, the publication is Hangzhou Shifan Daxue Xuebao, Ziran Kexueban (2012), 11(3), 217-221, database is CAplus.

A new Pt/CS-MCM-48 catalysts was prepared from chitosan supported on MCM-48. The catalyst was characterized by XRD, IR and TG. The results indicated that coordination bond between platinum and nitrogen atom of chitosan was formed. Pt/CS-MCM-48 catalyst has favorable catalytic performance for the hydrosilylation of alkenes, the regioselectivity of adduct is above 90%, and the catalyst can be reused for 14 times without noticeable loss of activity.

Hangzhou Shifan Daxue Xuebao, Ziran Kexueban published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C11H24O3, Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bai, Ying published the artcileUse of functionalized PEG with 4-aminobenzoic acid stabilized platinum nanoparticles as an efficient catalyst for the hydrosilylation of alkenes, Name: Dichloro(hexyl)(methyl)silane, the publication is Journal of Colloid and Interface Science (2013), 428-433, database is CAplus and MEDLINE.

A catalyst containing functionalized polyethylene glycol with 4-aminobenzoic acid (PEG-AMB) stabilized Pt nanoparticles was synthesized and characterized, and its application in the hydrosilylation of alkenes studied. The functionalized PEG-stabilized Pt nanoparticles form a very efficient catalyst for the hydrosilylation of alkenes. The Pt nanoparticles can be fully immobilized in the PEG-AMB and recycled at least nine times without any obvious loss of catalytic activity.

Journal of Colloid and Interface Science published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Name: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bai, Ying published the artcileUse of functionalized PEG with 4-aminobenzoic acid stabilized platinum nanoparticles as an efficient catalyst for the hydrosilylation of alkenes, Synthetic Route of 14799-93-0, the publication is Journal of Colloid and Interface Science (2013), 428-433, database is CAplus and MEDLINE.

A catalyst containing functionalized polyethylene glycol with 4-aminobenzoic acid (PEG-AMB) stabilized Pt nanoparticles was synthesized and characterized, and its application in the hydrosilylation of alkenes studied. The functionalized PEG-stabilized Pt nanoparticles form a very efficient catalyst for the hydrosilylation of alkenes. The Pt nanoparticles can be fully immobilized in the PEG-AMB and recycled at least nine times without any obvious loss of catalytic activity.

Journal of Colloid and Interface Science published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics