Month: December 2022

Isbell, A. F. published the artcileSynthesis of organophosphorus compounds, Formula: C5H10Cl3O3P, the publication is United States Department of Commerce, Office of Technical Services, AD [ASTIA Document] (1961), 9 pp., database is CAplus.

Monoalkylphosphonates of the type RP(O)(OR’)₂(R = R’ = Me, Et, or Bu; R = Ph, R’ = Et; R = PhCH₂, R’ = Bu) were treated with Na metal, using either PhCH₃ or excess ester as solvent. In all cases, the gas R’H was given off, yields being 0.3-0.5 moles gas/mole ester in PhCH₃ and 0.1 or less in excess ester. In addition, white solids were formed; they were insoluble in PhCH₃ but soluble in excess ester. Viscosity and non-crystalline character increased with increasing mol. weight of R. These solids were believed to consist in part of RP(O)(OR’)ONa. Other compounds studied were (MeO)₃P; (EtO)₃P; (BuO)₃PO; triethyl α,α-dimethylphosphonoacetate; triethyl phosphonoformate; BuPhP(O)OBu, and Et₂P(O)OEt. Attempts were also made to synthesize fluoroalkylphosphonic esters. F₃CCl or F₃Cl with (BuO)₂P(O)Na or (EtO)₃P gave no reaction. (EtO)₃P(O)CCl₃ heated with KF.2H₂O gave 83% CHCl₃ and a salt-like product. RP(O)(OEt)₂ (R = ClCH₂ or Cl₂CH) heated with anhydrous KF gave no reaction, but Cl₃CP(O)(OEt)₂ reacted with KF or NaF to give FP(O)(OEt)₂, (b₄₇ 88.5-89.5°); n²⁷_D 1.3710; d₂₇ 1.1399.

United States Department of Commerce, Office of Technical Services, AD [ASTIA Document] published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ilhan, Suleyman published the artcileEssential Oils from Vitex agnus castus L. Leaves Induces Caspase-Dependent Apoptosis of Human Multidrug-Resistant Lung Carcinoma Cells through Intrinsic and Extrinsic Pathways, Product Details of C10H9ClF3NO2, the publication is Nutrition and Cancer (2021), 73(4), 694-702, database is CAplus and MEDLINE.

Essential oil (EO) fractions of plants are complex mixtures of volatile compounds with broad-spectrum biol. properties. In the current study, the EO content of Vitex agnus castus L. (VAC) leaves growing in the Aegean region of Turkey was extracted and identified. Then, VAC EOs were investigated for their potential antioxidant, cytotoxic and apoptotic effects in human H69AR multi-drug resistant cancer cells. EOs were isolated by hydrodistillation and chem. composition was determined by GC-MS. Cell viability was assessed via MTT and trypan blue assays. Antioxidant activity was evaluated by measuring the total antioxidant activity and free radical scavenging activity. Apoptosis was evaluated via DNA fragmentation and caspase 3/7 activity assays. Changes in the levels of apoptotic genes were determined by RT-qPCR. The results indicated strong antioxidant activity and cytotoxic effect on H69AR cancer cells but not on HEK-293 human normal cells indicating the tumor-specific effect. VAC EOs induced caspase 3/7 activation and apoptosis through triggering both extrinsic- and intrinsic-pathways by modulating Bcl-2, Bcl-XL, Bax, Bad, FADD, Caspase-8, Caspase-9, TRAIL R1/DR4 and TRAIL R2/DR5. This study revealed that VAC EOs may be a promising candidate in the development of novel therapeutic agents for multi-drug resistant lung cancer treatment.

Nutrition and Cancer published new progress about 18585-06-3. 18585-06-3 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Amine,Benzene,Amide, name is Ethyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate, and the molecular formula is C10H9ClF3NO2, Product Details of C10H9ClF3NO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hshieh, Fu-Yu published the artcileNote: correlation of closed-cup flash points with normal boiling points for silicone and general organic compounds, Application In Synthesis of 14799-94-1, the publication is Fire and Materials (1997), 21(6), 277-282, database is CAplus.

A correlation was developed between closed-cup flash points and normal b.ps. for organic silanes or siloxanes. In addition, a more general correlation was developed between these two properties for the general organic compounds, including silanes and siloxanes. The closed-cup flash points can be predicted using empirical equations. The standard estimation errors were 11.06 and 11.66°C for silicon-containing compounds (silanes and siloxanes) and general organic compounds (including silicon-containing compounds), resp.

Fire and Materials published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Application In Synthesis of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Holy, A. published the artcilePhosphorylation of nucleosides with trichloromethylphosphonic acid derivatives, HPLC of Formula: 866-23-9, the publication is Tetrahedron Letters (1972), 157-8, database is CAplus.

Ribonucleosides were phosphorylated selectively, to give the 2′-phosphate derivative, with Et trichloromethylphosphonate (I) when the ribonucleoside contained the cis-2′,3′-diol group. Treatment of uridine (over-night) with I in HCONMe2 containing Et3N gave 67% of the corresponding uridine nucleotide. Similarly prepared were the nucleotides of cytidine, adenosine, and 6-azauridine in 23, 45, and 3% yield, resp. Thymidine and 2′,3′-O-isopropylideneuridine did not give the nucleotides as they could not form a cyclic intermediate. -(α-L-Lyxofuranosyl)adenine, in which two cyclic intermediates were conformationally allowed, gave 95% of a nucleotide mixture containing 2- and 3-isomeric phosphates and the 3,5-cyclic phosphate in 23, 37, and 35% yield, resp.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, HPLC of Formula: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Herbain, Maurice published the artcileA biologic test of antilipemic heparin derivatives, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Clinica Chimica Acta (1960), 204-7, database is CAplus and MEDLINE.

cf. Velluz, et al., CA 53, 10555g, 19898g. Rabbits were fed a diet containing saturated fats and 200 mg./kg./day cholesterol for a period of 30 days. Those animals in which serum total cholesterol levels reached 8 g./l. or more were selected for testing. The ratio of β-lipoprotein lipide/total lipide exceeded 0.70 compared to a control value of 0.35. After removal of cholesterol from the diet for 24 hrs., 5 mg./kg. heparin or other antilipemic agent was injected intravenously and total and β-lipoprotein lipides (the latter were precipitated with dextran) were estimated at 6, 10, and 14 hrs. When the test was carried out with N-dimethylbenzoyl-N-desulfoheparin, its antilipemic activity was found to be slower but more intense than that of heparin.

Clinica Chimica Acta published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hansen, Bertil published the artcilePreparation of thiocholine esters. II. Esters of α- and β-methylthiocholine, Category: chlorides-buliding-blocks, the publication is Acta Chemica Scandinavica (1959), 159-62, database is CAplus.

cf. CA 52, 14538g. α-Methyl- and β-methylthiocholine halide esters of benzoic and the lower fatty acids were prepared in good yield from Me₂NCHMeCH₂SH (I), b₈₈ 71°, n²⁵_D 1.4538, d₂₅ 0.8693, and HSCHMeCH₂NMe₂ (II), b₇₀ 78.5°, n²⁵_D 1.4684, d₂₀ 0.9046, resp., by esterification with Ac₂O and quaternization with MeI. The α-Me esters were also prepared from 1,2-propylene sulfide by adding the acid bromide and then quaternizing with Et₃N. The II was synthesized (Renshaw, et al., CA 32, 7412¹) from Me₂NCH₂CHMeCl.HCl (III), m. 185°, and (H₂N)₂CS. An attempt to prepare I similarly from MeCHNMe₂CH₂Cl.HCl and (H₂N)₂CS gave only II; addition of Me₂NH to propylene sulfide, b₁ 74-6° (prepared in 58% yield from propylene oxide and (H₂N)₂CS, in Et₂O gave I as the only product. Esters of MeCHBrCH₂SH prepared were: 73% acetate, b₆ 72-3°; 66% propionate, b₉ 93-6°; 53% butyrate, b₈ 99.5-100.5°; and 53% valerate, b₁₀ 125-6.5°. Esters of α-methylthiocholine bromide: 63% acetate, m. 187°; 63% propionate, m. 154°; 54% butyrate, m. 170°; and 67% valerate, m. 179°. Also prepared were the acetate, b₁₁ 64.5-6°, propionate, b₁₂ 67-81°, butyrate, b₉ 80-8°, isobutyrate, b₁₀ 85-94°, valerate, b_0.07 53-60°, and benzoate, b_0.01 88-96°, of I, and the acetate, b₁₁ 76-82°, propionate, b₁₀ 78-88°, butyrate, b_1.8 74-85°, isobutyrate, b₁₂ 86-92°, valerate, b_0.3, and benzoate, b_0.03 120-5°, of II. α-Methylthiocholine bromide acetate, m. 188°, and the following β-methylthiocholine bromide esters (acetate, m. 168°, 67% butyrate, m. 164°, and 32% isobutyrate, m. 140°), α-methylthiocholine iodide esters (50% acetate, m. 164°, 61% propionate, m. 155°, 62% butyrate, m. 130°, 82% isobutyrate, m. 158°, 62% valerate, m. 152°, and 54% benzoate, m. 136°), and β-methylthiocholine iodide esters (70% acetate, m. 150°, 65% propionate, m. 132°, 67% butyrate, m. 164°, 32% isobutyrate, m. 140°, 31% valerate, m. 74°, and 76% benzoate, m. 194°) were prepared III refluxed 65 h. with (H₂N)₂CS in absolute EtOH gave 52% S-(1-dimethylamino-2-propyl)isothiuronium chloride hydrochloride, m. 154° (PrOH).

Acta Chemica Scandinavica published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Griffin, C. E. published the artcileReaction of trichloromethyl radicals with triethyl phosphite, Category: chlorides-buliding-blocks, the publication is Chemistry & Industry (London, United Kingdom) (1958), 415, database is CAplus.

CCl₄ and (EtO)₃P at 80° give 80-5% Cl₃CP(O)(OEt)₂ (I). The reaction is inhibited by hydroquinone but traces of Bz₂O₂ give a 4-fold increase in reaction rate (89% yield at 80°). Irradiation of the reaction mixture at room temperature with a Hanovia ultraviolet lamp gives 80% I; under similar conditions BrCCl₃ and (EtO)₃P give 88% I. No reaction is observed in the dark at room temperature (30 days). These results confirm the chain process proposed by Kamai and Kharrasova (C.A. 52, 3666a). I b₁₇ 137-8°, n²¹_D 1.4612; partial hydrolysis with PhNH₂ in PhMe at 110° gave the anilinium salt of monoethyl trichloromethanephosphonate, m. 181.6-2.2° (MeOH-PhMe).

Chemistry & Industry (London, United Kingdom) published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Griffin, C. E. published the artcilePhosphoryl stretching frequency correlation for phosphonic acid derivatives, Computed Properties of 866-23-9, the publication is Chemistry & Industry (London, United Kingdom) (1960), 1058-9, database is CAplus.

A plot of Σ σ* (Taft substituent constants) vs. γ_PO (as films in CS₂ or CCl₄) for 19 phosphonates [RP(O)XY] (I) gave a linear relationship; a least squares treatment of the data gave γ_PO = 16.80 Σσ* + 1198. The following I were studied (X = Y = OEt) (R given): Me, Et, Pr, Bu, n-C₆H₁₃, CH₂:CH, CH₂:CHCH₂, PhCH₂, Ph, ClCH₂, Cl₂CH, CCl₃ (II), BrCH₂, HOCH₂, AcCH₂. Also I (R, X, and Y given): Me, OMe, OMe; Me, OEt, NMe₂; Me, NMe₂, NMe₂ (III); Ph, H, OEt. The average deviation between calculated and observed frequencies was ±4 cm.^-1; the only significant deviation occurred with II and III, and may have arisen through disturbance of the normal inductive effects of the substituents by field effects. Major deviations from the linear relationship also occurred with frequency values obtained in the presence of H-bonding solvents. The following σ* values were tentatively assigned: (CH₂)₂CO₂Et, 0.39; (CH₂)₃CO₂Et, 0.39; NEt₂, 0.68.

Chemistry & Industry (London, United Kingdom) published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Computed Properties of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gramstad, Thor published the artcileStudies of hydrogen bonding. Part XXXIII. Dipole moments of phosphoryl compounds and their hydrogen-bonded complexes with phenol, Application In Synthesis of 866-23-9, the publication is Acta Chemica Scandinavica (1992), 46(11), 1087-91, database is CAplus.

The dipole moments of 33 phosphoryl compounds and of their hydrogen-bonded complexes with phenol have been determined in CCl₄ at 20°. In general there is no correlation between the dipole moments and the O-H stretching frequency shift accompanying the complexation of phenol with the phosphoryl compounds A smooth correlation is observed, however, for some series of closely related phosphoryl compounds The influence of the various substituents on the dipole moment is discussed. The vectorially calculated dipole moments of the complexes were smaller than the corresponding dipole moments obtained exptl. The vectorial difference, Δμ, is greatest for phosphoryl compounds containing the N-P:O and C₆H₅-P:O groups.

Acta Chemica Scandinavica published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gramstad, Thor published the artcileHydrogen bonding. XII. Correlation of the complexing ability of organophosphorus compounds with the Taft σ^* constant, Safety of Diethyltrichloromethylphosphonate, the publication is Spectrochimica Acta (1964), 20(4), 729-31, database is CAplus.

cf. CA 56, 15544b; 58, 1333a; 59, 13792b. The relation of the Taft substituent constant (Σσ^*) is linear with respect to log K^20°_association and the shift of the OH stretching vibration fundamental (Δv_OH) for 22 organophosphorus compounds in mixed solutions with phenol, ethanol, and α-naphthol in CCl₄. Σσ^* is also linear with respect to log K^20°_association for the organophosphorus compounds with iodine in CCl₄ solution, and with the wavelength shift of the visible absorption band of iodine from near 518 mμ. The relation between Σσ^* and P:O stretching frequencies in cm.^-1 (v_PO) is not linear for these organophosphorus compounds in CCl₄ solution, contrary to previous reports (Griffin, CA 55, 1415h). However, some of G.’s determinations of v_PO were on pure films, and these compounds are associated in the pure state.

Spectrochimica Acta published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Safety of Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics