Month: December 2022

Ruefenacht, Kurt published the artcilePhosphoric acid esters and thiophosphoric acid esters with some heterocyclic substitutions. 7. Thio- and dithiophosphoric acid esters of the GS 13005 type with some analog or homolog heterocyclic rings, Product Details of C3H3Br2ClO, the publication is Helvetica Chimica Acta (1973), 56(7), 2186-204, database is CAplus.

Analogs of the pesticide GS 13005 were prepared, including pyrazolinones of the type I, (R = Cl, OH), pyrazoles II, (R = H, Me, Cl; R1 = H, Cl, Br, NO2; R2 = H, Me, iso-Pr; R3 = Cl, OH), pyridazinones III, (R = H, Cl, Br, Me, Et; R1 = H, Cl, Me; R2 = H, Cl, Me; R3 = Cl, OH), thiadiazinones IV, (R = Me, Et; R1 = Cl, OH), and their mono- and dithiophosphates. The preparation, of analogous thiadiazepinones failed, giving instead pyrazolidinone derivatives Approx. 100 compounds were prepared

Helvetica Chimica Acta published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Product Details of C3H3Br2ClO.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Rebrova, R. N. published the artcileComparative study of the effect of decamine and decamethoxine on fungi of the genus Candida, diphtheria bacteria and pathogenic staphylococci, Formula: C38H74Cl2N2O4, the publication is Vestnik Dermatologii i Venerologii (1971), 45(11), 51-2, database is CAplus and MEDLINE.

Decamine [522-51-0] had a stronger fungistatic effect against Candida albicans than did decamethoxine (I) [38146-42-8], but I was more effective than decamine in preventing the growth of diphtheria bacteria and pathogenic staphylococci. I may be useful in treating diseases caused or complicated by diphtheria or staphylococci organisms.

Vestnik Dermatologii i Venerologii published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pernot, Robert published the artcileThe reaction of ethylene with sulfur monochloride (S₂Cl₂) and with sulfur dichloride (S₂Cl₂ + Cl₂) in the preparation of bis(2-chloroethyl) sulfide (mustard gas), Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Ann. chim. [12] (1946), 626-57, database is CAplus.

Crude mustard gas (I) as obtained in the Levinstein process is a clear yellow liquid, m. 10.5°, which does not deposit a trace of S when kept for over a year. On distillation in vacuo I gives 70% pure (ClCH₂CH₂)₂S.(II), m. 13.5°. I is only partially soluble in EtOH or ether. The m.p. is only slightly affected when byproducts are present. When 500 g. I is extracted with 500 cc. EtOH, 208 g. remains undissolved. On cooling the alc. solution, 130 g. II, m. 13.3°, crystallizes. When 500 g. I is cooled with ice-NaCl, 245 g. II, m. 12.5°, crystallizes. Distillation of 323 g. I gives 2 fractions, (a) 185 g., b₁₈ 110-15°, m. 13.3°, and (b) 40 g., b₁₈ 115-55°, m. 3.8°, the residue decomposing Redistillation of 40 g. of fraction a gives a fraction (c) 25 g., b₁₈ 110-15°, and 12 g., b₁₈ 120-35°, the latter being chiefly (ClCH₂CH₂)₂S₂ (III). Distillation of the EtOH solution gives II, but no III or (ClCH₂CH₂)₂S₃ (IV) is present. From the EtOH-insoluble part no definite product can be isolated even on distillation at 1 mm. It still contains a small amount of II which is removed by careful oxidation with H₂O₂, whereby II is oxidized to the H₂O-soluble sulfoxide while III and IV remain unchanged. The elementary composition of the residue after treatment with H₂O₂ corresponds to (ClCH₂CH₂)₂S₈ (V) which may be formed according to the following equation: 7S₂Cl₂ + 14C₂H₄ → 6 II + V. Treatment of 86 g. EtOH-insoluble product with moist NH₃ according to Felsing and Arenson (C.A. 15, 54) causes the separation of 16.5 g. S. The recovered product, now soluble in ether and C₆H₆, is free of N and has a composition corresponding to (ClCH₂CH₂)₂S₄ (VI). VI does not deposit S even after standing 6 mo. When VI is heated with S, the latter dissolves and seps. again on cooling. In an attempt to hydrolyze VI with alc. KOH no definite compound is formed. When VI is treated with Me₂CO, S is deposited with the formation of IV, m. 27°. IV is also formed when VI is treated with steam at 100 mm. An attempt to oxidize IV with BzO₂H, to transfer it into the iodine compound by heating it with NaI in a sealed tube, or to condense IV with PhONa or BzONa failed. Distillation of 50 g. IV at 1 mm. gives 40 g. yellow liquid, b₁ 120-35°. Redistillation of the latter gives 2 fractions, (d) 10 g., b₁ up to 120°, and (e) 28 g., b₁ 120-6°, containing chiefly IV, m. 26.5°. IV prepared according to Mann, et al. (C.A. 15, 2413), m. 25°; the mixed m.p. of the 2 preparations is 26°. When IV is heated with the theor. amount of S to form VI, the S dissolves but seps. again on cooling. IV when distilled at 40 mm. gives a small amount of III, b. 160-5°, which is not attacked by H₂O₂. When distilled at atm. pressure III gives a very small amount of II. These results show that III has the structure (ClCH₂CH₂S)₂ and not (ClCH₂CH₂)₂S:S, while IV has the structure ClCH₂CH₂S(:S)SCH₂CH₂Cl. When 220 g. EtOH-insoluble product is extracted 5 times with 200 cc. pure and dry Me₂CO and the Me₂CO is evaporated, 80 g. of yellow oil is obtained from which some (ClCH₂CH₂)₂SO crystallizes. The residual oil has a composition corresponding to (ClCH₂CH₂)₂S₅ (VII) and is insoluble in EtOH, petr. ether, and AcOH. Pyridine precipitates 8.5 g. S from 43 g. VII. Evaporation of the pyridine leaves an oil which on distillation at 3 mm. gives a mixture of III and IV. The Me₂CO-insoluble part (140 g.), when cooled, deposits 16 g. S. The filtrate consists of a polysulfide or a mixture of polysulfides high in S content (75.7-6.7%). The hypothesis that II is formed according to the equation S₂Cl₂ + 2C₂H₄ → II + S is not substantiated by the action of C₂H₄ upon S₅Cl₂. When 580 g. S₅Cl₂ is treated with C₂H₄, 733 g. reaction product is obtained from which 207 g. S deposits, giving 526 g. reaction product. From 342 g. S₂Cl₂, which equals 580 g. S₅Cl₂, and 142 g. C₂H₄, 484 g. reaction product is calculated while 526 g. is obtained. These results indicate that S₅Cl₂ reacts in the same way as S₂Cl₂. The following reaction mechanism is proposed: S₂Cl₂ + 3C₂H₄ gives a sesquimustard gas, (CH₂SCH₂CH₂Cl)₂ (VIII). VIII reacts with S₂Cl₂ to give 1 mol. II and ClSS₂CH₂CH₂Cl (IX); IX + C₂H₄ → IV. IV + S₂Cl₂ → Cl.S.CH₂CH₂Cl (X) + ClS₄CH₂CH₂Cl (XI); XI + C₂H₄ → II + VI, etc. SCl₂ + C₂H₄ gives 85% crude reaction product (XII), m. 5-8°. Distillation of 109.5 g. XII, m. 5.5°, gives 3 fractions: (f) 97.5 g., b₁₀ 93-6°, m. 10°; (g) 4.5 g., b₁₀ 96-105°; and 3.5 g. residue. Redistillation of 90 g. f gives a fraction, 76.5 g., b₁₂ 97-8°, m. 10°, which on redistillation gives 62.3 g., b₁₃ 101-2°, m. 10.2°, and 11.4 g., b₁₅ 102-4°, m. 11.8°. This indicates that with II other products come over. Because under the conditions used, SCl₂ can be considered to be a solution of Cl in a mixture of SCl₂ and S₂Cl₂, byproducts containing α-chlorinated compounds are formed which split off HCl with formation of ClCH:CHSCH₂CH₂Cl (XIII). II containing 8.8% XIII m. 9.9°. When SCl₂ in a 10% CCl₄ solution and C₂H₄ are allowed to react and the reaction product is distilled after the CCl₄ has been removed at 120°, II, b₁₀ 93.5-4°, m. 10.8°, is obtained. When 800 g. of the reaction product is extracted with EtOH only 31 g. insoluble product (XIV) is obtained. When Cl is passed into 250 g. XIV, the temperature rises to 45-50°. As soon as the temperature drops to room temperature the Cl current is stopped and the reaction product distilled in vacuo. Up to 70°/15 mm. the S-Cl compounds distill, and between 98° and 100° a few cc. of a turbid liquid distills. When C₂H₄ is passed at 30-40° into the residue, a vigorous reaction takes place. After the active Cl in the residue has disappeared, 303 g. of a clear red solution is obtained. Distillation of 238 g. of this solution gives 3 fractions: (h) 12.6 g., b₁₃ 40-97°; (i) 76.6 g., b₁₃ 97-107°; (j) 8.2 g., b₁₃ 107-25°. Redistillation of i gives a product, b₁₃ 98-101°, m. 8.6°. Oxidation of 4.3 g. of this product with H₂O₂ at 50° in AcOH gives 1.2 g. of a sulfoxide, m. 108°, which when mixed with the sulfoxide of II, m. 108°. These results indicate that the Cl splits the polysulfides, ClCH₂CH₂S(:S_x)S(:S_y)CH₂CH₂Cl, to give 2 mols. X, while the S is converted into SCl₂ which again reacts with C₂H₄ with excess formation of a certain amount of II. On the other hand, the Cl also reacts with X, giving rise to the formation of XIV.

Ann. chim. [12] published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileDevelopment of resistance of Candida albicans to chemotherapeutic preparations, Related Products of chlorides-buliding-blocks, the publication is Trudy Krymskogo Gosudarstvennogo Meditsinskogo Instituta (1974), 38-40, database is CAplus.

C. albicans grown in nutrient medium containing increasing concentrations of decamine [17349-05-2] and decamethoxin [38146-42-8] gradually developed resistance to these fungicides but retained their sensitivity to levorin [11014-70-3]. Morphol. and culture changes and decreased rates of carbohydrate catabolism accompanied the development of Candida resistance to decamine and decamethoxin.

Trudy Krymskogo Gosudarstvennogo Meditsinskogo Instituta published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileEffect of decamethylene-1,10-bis(N-dimethylcarbomenthoxymethylammonium) dichloride on agglutinin and complement titers under experimental conditions, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Immunologiya (Kiev) (1972), 133-6, database is CAplus.

Decamethylene-1,10-bis(dimethylcarbomenthoxymethylammonium) dichloride (I) [38146-42-8] administered s.c. to rabbits at 1 or 2 mg/kg daily for 14 days during immunization with typhoid vaccine did not inhibit the manufacture of agglutinins and increased complement titer. Similar administration of I for 14 days after termination of immunization did not affect complement or agglutinin levels of the blood.

Immunologiya (Kiev) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Application of N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ofner, P. published the artcileAmidone. Some isomeric chlorodialkylaminopropanes and their reaction with diphenylmethyl cyanide, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Journal of the Chemical Society (1951), 1800-3, database is CAplus.

MeCH(NMe₂)CO₂Et is reduced by the Bouveault-Blanc procedure to 55% of MeCH(NMe₂)CH₂OH (I), b. 145-8° (picrate, orange-yellow, m. 182-3°); 20 g. I in 45 cc. C₆H₆, added (20 min.) to 23 g. SOCl₂ in 90 cc. C₆H₆ at 0°, allowed to warm to room temperature, and refluxed 1.5 h., give 59% MeCH(NMe₂)CH₂Cl.HCl (II), m. 103-4°. Me₂NCH₂CHMeOH (III) yields a picrate, orange-yellow, m. 83-4°. III (20 g.) and 23 g. SOCl₂, as above, give 73% Me₂NCH₂CHMeCl.HCl (IV), m. 190-1°. I (20 g.) in 45 cc. C₆H₆, treated with 23 g. SOCl₂ in 90 cc. C₆H₆ and the gummy residue refluxed with 150 cc. Me₂CO, gives 34% IV; the II is removed by the Me₂CO. 1-Piperidino-2-propanol (b₇₆₂ 198-201°; picrate, m. 134-5°) gives with SOCl₂ 2-chloro-1-(1-piperidyl)propane-HCl (V), m. 213-14°. 1-(1-Piperidyl)-3-propanol (m. 66-7°) with SOCl₂ gives 1-chloro-3-(1-piperidyl)propane (VI), b₁₀ 79-80°; HCl salt, m. 213-14°. The mother liquor from V or VI did not contain the other isomer. 1-Allylpiperidine (picrate, m. 72-3°) does not add HCl. The base, Me₂NCH₂CHMeCl (VII), liberated from IV by dilute NH₄OH at 0° or with 40% NaOH at room temperature, is stable and gives the same picrate, even after distillation (b₃₅ 36-7°). The base liberated from II at room temperature by 40% NaOH solution is Me₂NCHMeCH₂Cl (VIII) (Schultz, et al., C.A. 42, 4934i). VIII can be heated in an inert solvent and can be agitated in an inert solvent with NaOH or NaNH₂ without undergoing decomposition or isomerization; on distillation in vacuo, VIII is isomerized and VII and VIII can be separated by fractional crystallization of the picrates. The relative proportions of the isomers formed in the alkylation of PhCH₂CN with VII or V were determined by effecting as complete as possible a separation of the isomers giving the more sparingly soluble salts. In the dimethylamino series, the N-compounds from the more sparingly soluble salts, whereas in the analogous piperidyl series, the salts of the iso compounds have the lowest solubility In the former series at least 60% of the cyanide was formed by isolation as 6-dimethylamino-4,4-diphenyl-3-heptane-HBr and in the latter at least 45% of the isocyanide as 3-imino-5-methyl-4,4-diphenyl-6-(1-piperidyl)hexane-2HCl. Thus, the relative proportions vary according to the nature of the basic groups of the Cl base employed in the alkylation.

Journal of the Chemical Society published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Morita, Hirokazu published the artcileDifferential thermographic features of some crystalline biopolymers, HPLC of Formula: 6249-56-5, the publication is Biopolymers (1966), 4(2), 215-22, database is CAplus.

Thermograms are shown for globular, serum, and blood plasma proteins, calf thymus DNA, sodium triticonucleate, sodium thermonucleate, sperm DNA, yeast RNA, adenosine 3′-phosphate, adenosine 5′-phosphate, disodium adenosine triphospate, adenosine, and deoxyadenosine. A pronounced effect of moisture on the differential thermal properties of DNA was observed. Solid-state denaturation may be one of the prominent thermal effects recorded by the differential thermal analysis of proteins and nucleic acids.

Biopolymers published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mistryukov, E. A. published the artcileSynthesis and steric structure of some 1-methyl-4-phenyl-4-piperidinols, COA of Formula: C7H16ClNO2, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1961), 623-6, database is CAplus.

cf. CA 52, 20159b. PhLi from 17 g. Li treated in Et₂O with 127.6 g. 1-methylperhydro-4-pyrindone gave, after refluxing 4 h. and treating with aqueous HCl, followed by NaOH, 44% 1-methyl-4-phenylperhydro-4-pyrindole (I), b_0.3 136-46°, m. 45.5-6.5° (HCl salt m. 221-2°), along with a small amount of a base, C₂₃H₂₉NO, m. 71-2°; the mother liquors gave a base, m. 4850° (picrate decomposed at 199-200°; propionate HCl salt m. 206-7°), whose structure was not determined I formed a picrate, m. 157-7.5°. PhLi and 1-methyldecahydro-4-quinolone gave 63.7% isomeric alcs. in 62:24:14 ratio: α-form of 1-methyl-4-phenyldecahydro-4-quinolol, m. 126.5-7°; β-form, m. 112-13° (HCl salt m. 216-19°); and γ-form, m. 148-50°. Heating (CCMe₂OH)₂ with p-MeC₆H₄SO₃H in the presence of pyrogallol at 100°/100 mm. 1 h. gave H₂O and CO₂ and a residue of 2,5-dimethyl-1,5-hexadien-3-yne, b₄₀ 46-9°, and 2,5-dimethyl-5-hexen-3-yn-2-ol, b₁₃ 64-7°. Treatment of 2,5-dimethyl-1,4-hexadien-3-one and its MeOH adducts (crude mixture, Nazarov and Bukhmutskaya, CA 42, 7733e) with 39% aqueous MeNH₂ 2 days at room temperature gave, after treatment with H₂O and aqueous HCl, followed by NaOH, 40% 1,2,2,5-tetramethyl-4-piperidone, b₁₅ 90-3°, n²⁰_D 1.4620 (HCl salt m. 195.5°; picrate m. 180-80.5°). This and PhLi gave only 1 isomer of 1,2,2,5-tetramethyl-4-phenyl-4-piperidinol, m. 81-2°; HCl salt m. 201° (hydrate m. 152-3°). This piperidinol probably had equatorial Ph and Me groups at C-5. Only I showed evidence of internal H-bonding in the IR spectrum.

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mathieu, Didier published the artcileFlash Points of Organosilicon Compounds: How Data for Alkanes Combined with Custom Additive Fragments Can Expedite the Development of Predictive Models, Category: chlorides-buliding-blocks, the publication is Industrial & Engineering Chemistry Research (2012), 51(43), 14309-14315, database is CAplus.

A particularly simple approach to evaluate flash points (FP) from additive fragment contributions is outlined. Since it is based on a square root expression derived from examining n-alkane data, it avoids the need for nonlinear fitting procedures and for trial-and-error optimization of anal. relationship between FP and mol. descriptors. Despite a specially small number of additive contributions, the method can be applied to most organic mols. For organosilicon compounds, it exhibited some advantages vs. previously available procedures while providing very similar performance with an average absolute deviation from experiment close to 12° K, a determination coefficient R² = 0.89, and only 1 error >40° K.

Industrial & Engineering Chemistry Research published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Masamba, W. R. L. published the artcileDetection of trace amounts of chemical warfare agents in paint by gas chromatography and gas chromatography-mass spectrometry, COA of Formula: C4H8Cl2S2, the publication is Malawi Journal of Science & Technology (2001), 47-55, database is CAplus.

The chem. warfare agents pinacoly methylphosphonofluoridate (soman), bis[(2-chloroethylthio)ethyl] ether (O mustard), and tris(2-chloroethyl)amine (nitrogen mustard) and low levels of bis(2-chloroethyl) sulfide (mustard gas, H), 1,2-bis(2-chloroethylthio)ethane (Sesquimustard), and bis(2-chloroethyl) disulfide were detected by gas chromatog. and gas chromatog.-mass spectrometry in a paint sample that had been prepared by spiking soman, O mustard, and nitrogen mustard to simulate a case where chem. warfare agents were absorbed into a paint matrix. The results show that gas chromatog. and gas chromatog.-mass spectrometry can be used for the detection of such chem. warfare agents in paint samples.

Malawi Journal of Science & Technology published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, COA of Formula: C4H8Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics