Month: December 2022

Jamal Ahamed, V. S. published the artcileRadical polymerization of methyl methacrylate (MMA) initiated by KHSO₅-BTBAC system – a kinetic study, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Journal of Polymer Research (2012), 19(2), 1-8, database is CAplus.

Kinetics of free radical polymerization of Me methacrylate using potassium peroxomonosulfate as initiator in the presence of benzyltributylammonium chloride (BTBAC) as phase transfer catalyst was studied. The polymerization reactions were carried out under nitrogen atm. and unstirred conditions at a constant temperature of 60°C in Et acetate/water bi-phase system. The role of concentrations of monomer, initiator, catalyst, temperature, acid and ionic strength on the rate of polymerization (R_p) was ascertained. The orders with respect to monomer, initiator and phase transfer catalyst were found to be 1.5, 0.5 and 0.5 resp. The rate of polymerization (R_p) is independent of ionic strength and pH. Based on the kinetic results, a suitable mechanism is proposed.

Journal of Polymer Research published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Name: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ciganek, M. published the artcileModification of glass capillary inner surface for chromatography, Product Details of C9H20Cl2Si, the publication is Chemical Papers (1991), 45(1), 81-9, database is CAplus.

Conditions of glass capillary (50 μm inner diameter) inner surface modification by an aqueous solution of ammonia were studied. The resulting silica gel porous layer was modified chem. by methyloctyldichlorosilane. Under given etching conditions (temperature 250-300° for 16 h), a 5-10 volume% aqueous solution of ammonia was optimal. The static way of silylation by 10 volume% silane solution in toluene for 16 h at 250-280° with the column filled to 50-70% of its volume is optimal. This method provides a mech. stable porous layer 1-10 μm thick.

Chemical Papers published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Product Details of C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yamamoto, H. published the artcileOrally active cephalosporins. Part 3: synthesis, structure-activity relationships and oral absorption of novel C-3 heteroarylmethylthio cephalosporins, Synthetic Route of 75341-23-0, the publication is Bioorganic & Medicinal Chemistry (2001), 9(2), 465-475, database is CAplus and MEDLINE.

A series of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-(heteroarylmethylthio)cephalosporins was designed, synthesized and evaluated for antibacterial activity and oral absorption in rats. Antibacterial activity was markedly influenced by the structure of the heteroaromatic ring moiety. Oral absorption was influenced by the heteroaromatic ring moiety as well as by the arrangement of heteroatoms. Among these compounds, FK041, 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido]-3-[(pyrazol-3-yl)methylthio]-3-cephem-4-carboxylic acid, showed potent antibacterial activity against both Gram-pos. and Gram-neg. bacteria including Haemophilus influenzae. Further, it showed higher oral absorption than CFDN.

Bioorganic & Medicinal Chemistry published new progress about 75341-23-0. 75341-23-0 belongs to chlorides-buliding-blocks, auxiliary class Thiadiazole,Chloride, name is 2-(Chloromethyl)-5-methyl-1,3,4-thiadiazole, and the molecular formula is C17H14N2O2, Synthetic Route of 75341-23-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fushimi, Nobuhiko published the artcileDesign, synthesis, and structure-activity relationships of a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranosides substituted with novel hydrophilic groups as highly potent inhibitors of sodium glucose co-transporter 1 (SGLT1), Product Details of C19H34ClN, the publication is Bioorganic & Medicinal Chemistry (2013), 21(3), 748-765, database is CAplus and MEDLINE.

Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of therapeutic options for postprandial hyperglycemia. Previously, we reported potent and selective SGLT1 inhibitors 1 and 2 showing efficacy in oral carbohydrate tolerance tests in diabetic rat models. In a pharmacokinetic (PK) study of glycoside I (R = OH), excessive systemic exposure to metabolites of I (R = OH) was observed, presumably due to the high permeability of its aglycon. To further improve SGLT1 inhibitory activity and reduce aglycon permeability, a series of 4-benzyl-5-isopropyl-1H-pyrazol-3-yl β-D-glycopyranoside derivatives, e.g. I (R = NH₂), bearing novel hydrophilic substitution groups on the Ph ring were synthesized and their inhibitory activity toward SGLTs was evaluated. Optimized compound II showed an improved profile satisfying both higher activity and lower permeability of its aglycon. Moreover, the superior efficacy of II in various carbohydrate tolerance tests in diabetic rat models was confirmed compared with acarbose, an α-glucosidase inhibitor (α-GI) widely used in the clinic.

Bioorganic & Medicinal Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Product Details of C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kobatake, Seiya published the artcileAcid-induced photochromic system switching of diarylethene derivatives between P- and T-types, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Chemical Communications (Cambridge, United Kingdom) (2007), 1698-1700, database is CAplus and MEDLINE.

Diethylamino-substituted diarylethenes can switch between P-type photochromism (P-type = thermally stable isomers) and T-type (thermally unstable isomers) photochromism upon addition of trifluoromethanesulfonic acid. The protonated closed-form photoinduced color isomers return to open-ring isomers at a fast rate at elevated temperature such as 160° C. The protonation and deprotonation of the open- and closed isomers was reversible. Such photochromic materials could be used as reversible switching materials for write-by-light/erase-by-heat recording.

Chemical Communications (Cambridge, United Kingdom) published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kleinwaechter, Michael published the artcileOxidative and reductive cyclization in stiff dithienylethenes, HPLC of Formula: 219537-97-0, the publication is Beilstein Journal of Organic Chemistry (2018), 2812-2821, database is CAplus and MEDLINE.

The electrochem. behavior of stiff dithienylethenes, undergoing double bond isomerization in addition to ring-closure, has been investigated. Electrochromism was observed in almost all cases, with the major pathway being the oxidatively induced cyclization of the open isomers. The influence of the ring size (to lock the reactive antiparallel conformation) as well as substituents (to modulate the redox potential) on the electrocyclization was examined In the series of derivatives with 6-membered rings, both the E- and the Z-isomer convert to the closed isomer, whereas for the 7-membered rings no cyclization from the E-isomer was observed For both stiff and normal dithienylethenes bearing benzonitrile substituents an addnl. and rare reductive electrocyclization was observed The mechanism underlying both observed electrocyclization pathways has been elucidated.

Beilstein Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, HPLC of Formula: 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Griffiths, W. Richard published the artcileThe mass spectra of phosphonyl compounds. Part 3. Dimethyl- and diethylalkane and substituted-methane phosphonates, Category: chlorides-buliding-blocks, the publication is Phosphorus and Sulfur and the Related Elements (1978), 5(1), 101-6, database is CAplus.

The electron impact spectra of 28 related phosphonates were determined Et, Me₂CH, and Me₃C groups which are bound directly to P, fragment to the corresponding alkenes; similar Me₂CH, Me₃C groups in the di-Me esters also fragment to ethylene and propene, resp., i.e., the P-alkyl rearranges with transfer of the elements of a Me group to the P ion. The di-Et alkenephosphonates undergo double H rearrangements of an ethoxy group to give dihydroxyphosphonium ions. The di- and trihydroxyphosphonium ions have a characteristic fragmentation which involves loss of water. This characteristic has been used as evidence for the rearrangement of a phosphacylium ion to a dihydroxyphosphonium ion.

Phosphorus and Sulfur and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Greguric, Ivan published the artcileDiscovery of [¹⁸F]N-(2-(Diethylamino)ethyl)-6-fluoronicotinamide: A Melanoma Positron Emission Tomography Imaging Radiotracer with High Tumor to Body Contrast Ratio and Rapid Renal Clearance, Recommanded Product: 2-Chloroisonicotinic acid, the publication is Journal of Medicinal Chemistry (2009), 52(17), 5299-5302, database is CAplus and MEDLINE.

The high melanoma uptake and rapid body clearance displayed by our series of [¹²³I]iodonicotinamides prompted the development of [¹⁸F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide, a novel radiotracer for PET melanoma imaging. Significantly, unlike fluorobenzoates, [¹⁸F]fluorine incorporation on the nicotinamide ring is one step, facile, and high yielding. [¹⁸F]N-(2-(diethylamino)ethyl)-6-fluoronicotinamide displayed high tumor uptake, rapid body clearance via predominantly renal excretion, and is currently being evaluated in preclin. studies for progression into clin. trials to assess the responsiveness of therapeutic agents.

Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roy, Aroop K. published the artcileThe First Alkene-Platinum-Silyl Complexes: Lifting the Hydrosilation Mechanism Shroud with Long-Lived Precatalytic Intermediates and True Pt Catalysts, Safety of Dichloro(hexyl)(methyl)silane, the publication is Journal of the American Chemical Society (2002), 124(32), 9510-9524, database is CAplus and MEDLINE.

The synthesis, characterization, and exploratory chem. of two classes of alkene-platinum-silyl complexes, which have been postulated as hydrosilation intermediates, are described in this report. The unique dimeric complexes 1, [R₃Si(μ-Cl)(η²-COD)Pt]₂ {R₃Si = Et₃Si, MeCl₂Si, Me₂ClSi, “(EtO)₃Si”, PhMe₂Si, and (Me₃SiO)Me₂Si; COD = cycloocta-1,5-diene}, and the bis-silyl complexes 2, (η⁴-COD)Pt(SiR₃)₂ (R₃Si = Cl₃Si, MeCl₂Si, Me₂ClSi, PhMe₂Si), are formed from the sequential reaction of 2 and 4 equivalent of the corresponding hydrosilanes, resp., with Pt(COD)Cl₂ in the presence of a small excess of COD. Complexes 1 are stable for many days in solution at room temperature but decompose via slow elimination of chlorosilane. Some of the bis-silyl compounds 2 are stable for extended periods under inert atm. and especially below 0°, either in the solid state or in solution (in the presence of a small excess of free COD). Complexes 2 display catalytic activity as discrete, mol., and mononuclear species for hydrosilation and isomerization reactions. Compound 2c (R₃Si = MeCl₂Si) was fully characterized via multinuclear NMR spectroscopy and x-ray crystal structure anal. The facile H-transfer rather than Si-transfer to bound COD provides exptl. support for the sequence of insertive steps in the Chalk-Harrod catalytic cycle, at least for Pt-catalyzed hydrosilation.

Journal of the American Chemical Society published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Safety of Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Phillips, Duncan A. S. published the artcileThe dyeing performance on cotton of reactive dyes containing the α-bromoacrylamido group, Related Products of chlorides-buliding-blocks, the publication is Dyes and Pigments (1999), 43(2), 153-160, database is CAplus.

Three reactive azo dyes containing the α-bromoacrylamido group have been synthesized and their performance assessed for the exhaust dyeing of cotton. The results indicate that, when situated in the appropriate electronic environment in the dye mol., this reactive group is compatible with the sulfatoethylsulfonyl (vinylsulfonyl) group in delivering warm dyeing (60°C) characteristics.

Dyes and Pigments published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics