December 2022 - Page 272 of 276 - Chlorides-buliding-blocks

Shames, Spencer L.’s team published research in Journal of the American Chemical Society in 103 | CAS: 866-23-9

Journal of the American Chemical Society published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C42H63O3P, Product Details of C5H10Cl3O3P.

Shames, Spencer L. published the artcileAcyl substituent effects on rates of acyl transfer to thiolate, hydroxide, and oxy dianions, Product Details of C5H10Cl3O3P, the publication is Journal of the American Chemical Society (1981), 103(20), 6170-7, database is CAplus.

The rates of transfer of polar aliphatic acyl groups (with σ^* -0.3 to +1.05) from aqueous p-nitrophenol to OH^–, the thiol anion of N-acetyl-L-cysteine, or phosphonate dianions are determined The rate constants for the saponification of ten p-O₂NC₆H₄O₂CR (I; R = alkyl) aretreated via an LFER with ρ^* 2.9. The ρ^* value for the thiolysis reaction is only slightly larger (16 ± 13%) than that for saponification These kinetic ρ^* values are essentially identical with the equilibrium ρ^* for OH^– or thiolate addition to aldehydes. To the extent that gem diolate and thiohemiacetalate formation are appropriate model reactions for the formation of the anionic tetrahedral intermediates in the corresponding acyl transfer reactions, the magnitude of the kinetic ρ^* values suggests that the transition states for the saponification and for the thiolysis reactions are similar, in geometry and charge distribution, to the tetrahedral intermediates. Acyl transfer from p-nitrophenol to phosphonate dianions involves an uncatalyzed nucleophilic displacement by the oxy dianion. The ρ^* for the reaction of ClCH₂PO₃^2- with I is 2.4. The second-order rate constants for the reactions between the phosphonates and I (R = Me, ClCH₂) and p-O₂NC₆H₄OAc show a small sensitivity to the basicity of the nucleophile (β_nuc ∼0.3). An explanation of the magnitudes of the ρ^* and β_nuc values, and of the anomalously low reaction rates (relative to oxy monoanions and amines of comparable basicities) for acyl transfer to the phosphates, is that electrostatic interactions and desolvation of the oxy dianion make substantial contributions to the activation energy barrier for nucleophilic attack.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhai, Yan’s team published research in Biomacromolecules in 19 | CAS: 219537-97-0

Biomacromolecules published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C18H20N2O12, SDS of cas: 219537-97-0.

Zhai, Yan published the artcilePhotoswitchable micelles for the control of singlet-oxygen generation in photodynamic therapies, SDS of cas: 219537-97-0, the publication is Biomacromolecules (2018), 19(6), 2023-2033, database is CAplus and MEDLINE.

Inadvertent photosensitizer-activation and singlet-oxygen generation hampers clin. application of photodynamic therapies of superficial tumors or s.c. infections. Therefore, a reversible photoswitchable system was designed in micellar nanocarriers using ZnTPP as a photosensitizer and BDTE as a photoswitch. Singlet-oxygen generation upon irradiation did not occur in closed-switch micelles with ZnTPP/BDTE feeding ratios >1:10. Deliberate switch closure/opening within 65-80 min was possible through thin layers of porcine tissue in vitro, increasing for thicker layers. Inadvertent opening of the switch by simulated daylight, took several tens of hours. Creating deliberate cell damage and prevention of inadvertent damage in vitro and in mice could be done at lower ZnTPP/BDTE feeding ratios (1:5) in open-switch micelles and at higher irradiation intensities than inferred from chem. clues to generate singlet-oxygen. The reduction of inadvertent photosensitizer activation in micellar nanocarriers, while maintaining the ability to kill tumor cells and infectious bacteria established here, brings photodynamic therapies closer to clin. application.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Flynn, Richard M.’s team published research in Journal of Fluorine Chemistry in 132 | CAS: 866-23-9

Journal of Fluorine Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application of Diethyltrichloromethylphosphonate.

Flynn, Richard M. published the artcileSynthetic and mechanistic aspects of halo-F-methylphosphonates, Application of Diethyltrichloromethylphosphonate, the publication is Journal of Fluorine Chemistry (2011), 132(10), 815-828, database is CAplus.

The synthesis of a variety of new halo-F-methylphosphonates has been achieved by a Michaelis-Arbuzov type reaction between a halo-F-methane and a trialkyl phosphite. This synthesis has proved to be of wide scope and utility for the high yield preparation of a number of heretofore unknown compounds The ¹H, ¹⁹F, ¹³C and ³¹P NMR spectroscopic properties are reported in detail. The mechanism for the formation of bromodifluoromethylphosphonates has been shown to proceed through the intermediacy of difluorocarbene :CF₂. The phosphonate products have been shown to react with a wide variety of reagents. Fluoride and alkoxide ions react by attack at phosphorus with cleavage of the carbon-phosphorus bond and formation of [:CF₂] from the bromodifluoromethylphosphonates and the CFBr₂ ^– anion from the dibromofluoromethylphosphonates. Iodide ion and tertiary phosphines react by attack at the ester carbon to give stable phosphonate salts. Hydrolysis of the phosphonate esters with 50% aqueous HCl gives the expected phosphonic acids. Trimethylsilyl bromide attacks phosphoryl oxygen to afford the bis(trimethylsilyl) esters.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kantchev, E. A. B. et al. published their research in Science of Synthesis in 2009 | CAS: 6294-17-3

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).COA of Formula: C6H12BrCl

Synthesis of acyclic alkanes by metal substitution with extension of the carbon framework was written by Kantchev, E. A. B.;Organ, M. G.. And the article was included in Science of Synthesis in 2009.COA of Formula: C6H12BrCl The following contents are mentioned in the article:

A review of methods to prepare acyclic alkanes by metal substitution with extension of the carbon framework. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3COA of Formula: C6H12BrCl).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Shaw, Scott A. et al. published their research in Journal of Organic Chemistry in 2015 | CAS: 141109-14-0

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development [Erratum to document cited in CA163:218209] was written by Shaw, Scott A.;Balasubramanian, Balu;Bonacorsi, Samuel;Caceres Cortes, Janet;Cao, Kevin;Chen, Bang-Chi;Dai, Jun;Decicco, Carl;Goswami, Animesh;Guo, Zhiwei;Hanson, Ronald;Humphreys, W. Griffith;Lam, Patrick Y. S.;Li, Wenying;Mathur, Arvind;Maxwell, Brad D.;Michaudel, Quentin;Peng, Li;Pudzianowski, Andrew;Qiu, Feng;Su, Shun;Sun, Dawn;Tymiak, Adrienne A.;Vokits, Benjamin P.;Wang, Bei;Wexler, Ruth;Wu, Dauh-Rurng;Zhang, Yingru;Zhao, Rulin;Baran, Phil S.. And the article was included in Journal of Organic Chemistry in 2015.Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:

Other work on clopidogrel metabolite synthesis was omitted from the reference list; a corrected reference 13 is given. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Safety of (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Goralski, Pawel et al. published their research in Journal of Chemical & Engineering Data in 2012 | CAS: 6294-17-3

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 1-Bromo-6-chlorohexane

Heat Capacity of α,ω-Bromochloroalkanes and α,ω-Dibromoalkanes: Their Dependence on the Hydrocarbon Chain Length and Temperature (285.15 to 355.15) K [Erratum to document cited in CA156:296087] was written by Goralski, Pawel;Tkaczyk, Mariola. And the article was included in Journal of Chemical & Engineering Data in 2012.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

On page 793, Table 4 and Figure 2 contained errors in the C_p data; the corrected table and figure are given. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Batt, S. B. et al. published their research in Chemical Era in 1979 | CAS: 2272-40-4

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Studies on s-triazines. Part VIII. Preparation of L (+) or (-)-2-arylamino-4,6-di-α-glutarylamino-s-triazines was written by Batt, S. B.;Khunt, V. N.;Parikh, A. R.. And the article was included in Chemical Era in 1979.Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

The title triazines were prepared by acylation of 2-(arylamino)-4,6-dichloro-s-triazine with L-(+)-glutamic acid in HCl. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Quality Control of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Kumar, G. Jagadeesh et al. published their research in Medicinal Chemistry Research in 2017 | CAS: 2272-40-4

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Erratum to: Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents [Erratum to document cited in CA163:520453] was written by Kumar, G. Jagadeesh;Kumar, S. Naveen;Thummuri, Dinesh;Adari, Lavanya Bindu Sree;Naidu, V. G. M.;Srinivas, Kolupula;Rao, V. Jayathirtha. And the article was included in Medicinal Chemistry Research in 2017.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

In the original publication, the IC₅₀ values of compounds 15f, 15g and their resp. dose response curves in Fig. 1 are incorrect; the correction is provided here. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Smolobochkin, A. V. et al. published their research in Russian Journal of General Chemistry in 2022 | CAS: 95-88-5

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Reactions of Aminoacetals with C-Nucleophiles as a New Method for the Synthesis of Di(het)arylmethane Derivatives with a Taurine Fragment was written by Smolobochkin, A. V.;Yakhshilikova, L. J.;Bekrenev, D. D.;Gazizov, A. S.;Burilov, A. R.;Pudovik, M. A.. And the article was included in Russian Journal of General Chemistry in 2022.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

Based on the acid-catalyzed reaction of functionalized aminoacetals with C-nucleophiles, a series of new diarylmethane derivatives with a taurine fragment were synthesized. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Smolobochkin, A. V. et al. published their research in Russian Journal of Organic Chemistry in 2017 | CAS: 95-88-5

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 4-Chlororesorcinol

Reaction of 9-[2-(1,3-dioxolan-2-yl)ethyl]-9H-purin-6-amine with phenols. Synthesis of diarylpropanes was written by Smolobochkin, A. V.;Gazizov, A. S.;Vagapova, L. I.;Burilov, A. R.;Bogdanov, A. A.;Pudovik, M. A.. And the article was included in Russian Journal of Organic Chemistry in 2017.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

New 1,1-diarylpropanes containing an adenine fragment on C³ have been synthesized by reaction of 9-[2-(1,3-dioxolan-2-yl)ethyl]-9H-purin-6-amine with phenols in aqueous HCl. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics