Month: December 2022

Boyer, John-Christopher published the artcilePhotomodulation of Fluorescent Upconverting Nanoparticle Markers in Live Organisms by Using Molecular Switches, Computed Properties of 219537-97-0, the publication is Chemistry – A European Journal (2012), 18(11), 3122-3126, S3122/1-S3122/17, database is CAplus and MEDLINE.

It is successfully demonstrated that the ability to modulate the luminescence from upconverting nanoparticles in vitro and in vivo by taking advantage of the well-understood photochem. of DTE mol. switches decorated onto nanoparticle surfaces by the use of CuACC chem. By reversibly converting the photoswitch back and forth between the two isomers by using UV and visible light, we are able to toggle the system between on (bright fluorescence) and off (quenched fluorescence) states. This process can be cycled multiple times before any degradation of the nanoparticles or the photo-switch renders the system impractical. The system has an advantage over ‘caged’ fluorophores as the luminescence of our designed nanoparticles can be repeatedly cycled through on and off states. Systems such as the one described not only have the capacity to reversibly control the intensity of the probe emission, through selective absorption, they can also alter the color of the emitted light from multicolored probes; this further enhances the imaging capabilities.

Chemistry – A European Journal published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Computed Properties of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Benalil, Aziza published the artcileSynthesis of 1,2-aminoazides. Conversion to unsymmetrical vicinal diamines by catalytic hydrogenation or reductive alkylation with dichloroboranes, SDS of cas: 4584-49-0, the publication is Tetrahedron (1991), 47(38), 8177-94, database is CAplus.

1,2-Aminoazides, e.g., I, are easily prepared from 1,2-amino alcs. Catalytic hydrogenation in the presence of palladium on charcoal or reductive alkylation with dichloroboranes afford with good yields unsym. substituted vicinal diamines.

Tetrahedron published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Morant-Giner, Marc published the artcileFunctionalisation of MoS₂ 2D layers with diarylethene molecules, COA of Formula: C15H14Cl2S2, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2021), 9(33), 10975-10984, database is CAplus.

Functionalisation of two-dimensional (2D) materials with stimuli-responsive mols. has been scarcely investigated. Here, MoS₂ layers obtained by chem. exfoliation are covalently and non-covalently functionalised using two photoswitchable diarylethene derivatives under their open- and closed-ring isomers. The choice of these light-responsive mols. is based on their excellent thermal irreversibility and fatigue resistance. The characterization of the resultant mol./2D heterostructures proves the successful anchoring of the mols. by both approaches as well as the influence that the driving interaction has on the photoswitching behavior of the diarylethene isomers after their deposition on the 2D layer.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, COA of Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gan, Haifeng published the artcileSynthesis of 2-Arylbenzoselenazoles from Se-mediated Redox Condensation of 2-Chloronitrobenzene and Arylmethyl Chlorides, Related Products of chlorides-buliding-blocks, the publication is ChemistrySelect (2020), 5(15), 4548-4551, database is CAplus.

A selenium-mediated redox condensation of 2-chloronitrobenzenes 2-Cl-RC₆H₃NO₂ (R = H, 4-Me, 5-F, 5-CF₃, etc.) and arylmethyl chlorides R¹CH₂Cl (R¹ = Ph, naphthalen-1-yl, pyridin-3-yl, etc.) to obtain 2-arylbenzoselenazoles I (R² = H, 6-Me, 5-F, 5-Br, etc.) has been realized under metal-free condition. The reactions proceeded in moderate-to-good yields with good functional compatibility and gram-scale achievement. Primarily mechanistic investigation suggested that key intermediate Bn(Se)nBn II, was first isolated and confirmed by NMR.

ChemistrySelect published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gan, Haifeng published the artcileSynthesis of 2-Arylbenzoselenazoles from Se-mediated Redox Condensation of 2-Chloronitrobenzene and Arylmethyl Chlorides, Category: chlorides-buliding-blocks, the publication is ChemistrySelect (2020), 5(15), 4548-4551, database is CAplus.

A selenium-mediated redox condensation of 2-chloronitrobenzenes 2-Cl-RC₆H₃NO₂ (R = H, 4-Me, 5-F, 5-CF₃, etc.) and arylmethyl chlorides R¹CH₂Cl (R¹ = Ph, naphthalen-1-yl, pyridin-3-yl, etc.) to obtain 2-arylbenzoselenazoles I (R² = H, 6-Me, 5-F, 5-Br, etc.) has been realized under metal-free condition. The reactions proceeded in moderate-to-good yields with good functional compatibility and gram-scale achievement. Primarily mechanistic investigation suggested that key intermediate Bn(Se)nBn II, was first isolated and confirmed by NMR.

ChemistrySelect published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Jinhui published the artcileUnveiling Extreme Photoreduction Potentials of Donor-Acceptor Cyanoarenes to Access Aryl Radicals from Aryl Chlorides, Related Products of chlorides-buliding-blocks, the publication is Journal of the American Chemical Society (2021), 143(33), 13266-13273, database is CAplus and MEDLINE.

Since the seminal work of Zhang in 2016, donor-acceptor cyanoarene-based fluorophores, such as 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene (4CzIPN), have been widely applied in photoredox catalysis and used as excellent metal-free alternatives to noble metal Ir- and Ru-based photocatalysts. However, all the reported photoredox reactions involving this chromophore family are based on harnessing the energy from a single visible light photon, with a limited range of redox potentials from -1.92 to +1.79 V vs SCE. Here, we document the unprecedented discovery that this family of fluorophores can undergo consecutive photoinduced electron transfer (ConPET) to achieve very high reduction potentials. One of the newly synthesized catalysts, 2,4,5-tri(9H-carbazol-9-yl)-6-(ethyl(phenyl)amino)isophthalonitrile (3CzEPAIPN), possesses a long-lived (12.95 ns) excited radical anion form, 3CzEPAIPN^•-*, which can be used to activate reductively recalcitrant aryl chlorides (E_red ≈ -1.9 to -2.9 V vs SCE) under mild conditions. The resultant aryl radicals can be engaged in synthetically valuable aromatic C-B, C-P, and C-C bond formation to furnish arylboronates, arylphosphonium salts, arylphosphonates, and spirocyclic cyclohexadienes.

Journal of the American Chemical Society published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C11H24O3, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jin, Piaopiao published the artcileMulti-responsive diarylethene-phenolphthalein hybrids by multiple stimuli, COA of Formula: C15H14Cl2S2, the publication is Tetrahedron (2016), 72(35), 5488-5494, database is CAplus.

Photochromic diarylethene derivatives cherishing phenolphthalein moieties were designed and constructed. We present efforts to investigate their versatile performances in multi-responsive properties with multiple stimuli of light, acid/base and temperature/heat. Results show their fluorescence could be on-off switched not only by different lights but also by acid/base. Besides lights and acid/base controllable color change and fluorescence-changing, altering phase states could also tune their colors via different temperature, which is rare performance for diarylethene derivatives Especially, the photocyclization ratio is as high as 100% for compound 2o bearing two phenolphthalein groups. These versatile properties are helpful to the design of pH sensitive photoswitches, fluorescent sensors, and mol. logical gates.

Tetrahedron published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, COA of Formula: C15H14Cl2S2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun published the artcileQuantifying and fine adjusting the solid-state fluorescence wavelength of 1-thienyl-2-arylethylene, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene, the publication is Journal of Luminescence (2021), 117895, database is CAplus.

Thirty two 1-thienyl-2-arylethylene derivatives (XAEY) were synthesized and their solid-state fluorescence emission wavelengths Em (nm) were determined The effects of substituents X and Y on the fluorescence wavelengths were analyzed in detail. The quant. correlation anal. for the Em was carried out by employing the ground-state polarity parameters and excited-state parameters of the substituents X and Y. A quant. equation was obtained and its reliability was verified by the leave-one-out (LOO) method. The obtained results show: (1) For the compounds XAEY, when the group Y on the aryl group is fixed, the Em order is 2′-methyl-2-thienyl-AEY > 3-thienyl-AEY > 2-thienyl-AEY; when thienyl (X) is fixed, the Em of XAEY with electron-withdrawing group Y is longer than that of XAEY with electron-donating group Y; (2) The Em of XAEY can be finely adjusted by changing groups X and Y. That is, one can obtain a series of compounds with continuous fluorescence emission wavelength in range of 450-600 nm via selecting different groups X or Y. (3) The 2′-Me has an addnl. red shift effect on the Em of 2′- methyl-2-thienyl-AEY. The results of this paper can provide an important reference for studying theor. solid-state fluorescence emission spectra of organic compounds and designing corresponding fluorescent material mols.

Journal of Luminescence published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Recommanded Product: 1-(Chloromethyl)-4-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cao, Chaotun published the artcileQuantifying and fine adjusting the solid-state fluorescence wavelength of 1-thienyl-2-arylethylene, Recommanded Product: 3-Chlorobenzylchloride, the publication is Journal of Luminescence (2021), 117895, database is CAplus.

Thirty two 1-thienyl-2-arylethylene derivatives (XAEY) were synthesized and their solid-state fluorescence emission wavelengths Em (nm) were determined The effects of substituents X and Y on the fluorescence wavelengths were analyzed in detail. The quant. correlation anal. for the Em was carried out by employing the ground-state polarity parameters and excited-state parameters of the substituents X and Y. A quant. equation was obtained and its reliability was verified by the leave-one-out (LOO) method. The obtained results show: (1) For the compounds XAEY, when the group Y on the aryl group is fixed, the Em order is 2′-methyl-2-thienyl-AEY > 3-thienyl-AEY > 2-thienyl-AEY; when thienyl (X) is fixed, the Em of XAEY with electron-withdrawing group Y is longer than that of XAEY with electron-donating group Y; (2) The Em of XAEY can be finely adjusted by changing groups X and Y. That is, one can obtain a series of compounds with continuous fluorescence emission wavelength in range of 450-600 nm via selecting different groups X or Y. (3) The 2′-Me has an addnl. red shift effect on the Em of 2′- methyl-2-thienyl-AEY. The results of this paper can provide an important reference for studying theor. solid-state fluorescence emission spectra of organic compounds and designing corresponding fluorescent material mols.

Journal of Luminescence published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cruz-Migoni, Abimael published the artcileStructure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds, Computed Properties of 944129-07-1, the publication is Proceedings of the National Academy of Sciences of the United States of America (2019), 116(7), 2545-2550, database is CAplus and MEDLINE.

The RAS gene family is frequently mutated in human cancers, and the quest for compounds that bind to mutant RAS remains a major goal, as it also does for inhibitors of protein-protein interactions. We have refined crystallization conditions for KRAS169Q61H-yielding crystals suitable for soaking with compounds and exploited this to assess new RAS-binding compounds selected by screening a protein-protein interaction-focused compound library using surface plasmon resonance. Two compounds, referred to as PPIN-1 and PPIN-2, with related structures from 30 initial RAS binders showed binding to a pocket where compounds had been previously developed, including RAS effector protein-protein interaction inhibitors selected using an intracellular antibody fragment (called Abd compounds). Unlike the Abd series of RAS binders, PPIN-1 and PPIN-2 compounds were not competed by the inhibitory anti-RAS intracellular antibody fragment and did not show any RAS-effector inhibition properties. By fusing the common, anchoring part from the two new compounds with the inhibitory substituents of the Abd series, we have created a set of compounds that inhibit RAS-effector interactions with increased potency. These fused compounds add to the growing catalog of RAS protein-protein inhibitors and show that building a chem. series by crossing over two chem. series is a strategy to create RAS-binding small mols.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 944129-07-1. 944129-07-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester,, name is (4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H7BClFO3, Computed Properties of 944129-07-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics