Month: December 2022

Shen, Kun published the artcileDesign and synthesis of twin drug with nNOS-PSD-95 interrupts and gabapentin, pregabalin, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde, the publication is Nanjing Yike Daxue Xuebao, Ziran Kexueban (2014), 34(10), 1441-1445, database is CAplus.

The compounds of twin drug with nNOS-PSD-95 interrupts and gabapentin, pregabalin were designed, and new drugs for the treatment of neuropathic pain were found. The nNOS-PSD-95 interrupts and gabapentin, pregabalin were connected to form amide. The analgesic effects of target compounds were evaluated by neuropathic pain model. All target compounds showed different degree analgesic effects in neuropathic pain, the analgesic effect of twin drug of nNOS-PSD-95 interrupts and gabapentin, pregabalin twin drug in neuropathic pain was stronger than that of single target drugs. Twin drug with nNOSPSD-95 interrupts and gabapentin, pregabalin may get a better analgesic effect than that of single target drugs in neuropathic pain.

Nanjing Yike Daxue Xuebao, Ziran Kexueban published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H8INO, Name: 5-Bromo-3-chloro-2-hydroxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, Zhiqiang published the artcileUracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers, SDS of cas: 854778-30-6, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(10), 2519-2522, database is CAplus and MEDLINE.

Uracil derivatives I [X¹ = F, CF₃; X² = F, SO₂Me, Cl, MeS, etc.; Y = 2-F-3-OMe, 2-Cl, H, 2-F, etc.] were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor. Optimization at the 1- and 5-positions of the uracil resulted in potent compounds such as I [X¹ = F, X² = CF₃, Y = 2-Cl-3-OMe] (K_i = 0.45 nM).

Bioorganic & Medicinal Chemistry Letters published new progress about 854778-30-6. 854778-30-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (2-Chloro-3-methoxyphenyl)boronic acid, and the molecular formula is C7H8BClO3, SDS of cas: 854778-30-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guo, Zhiqiang published the artcileUracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers, Name: 2-Chloro-4-methylphenylboronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(10), 2519-2522, database is CAplus and MEDLINE.

Uracil derivatives I [X¹ = F, CF₃; X² = F, SO₂Me, Cl, MeS, etc.; Y = 2-F-3-OMe, 2-Cl, H, 2-F, etc.] were designed and synthesized to avoid atropisomers observed in the 6-methyluracils as antagonists of the human GnRH receptor. Optimization at the 1- and 5-positions of the uracil resulted in potent compounds such as I [X¹ = F, X² = CF₃, Y = 2-Cl-3-OMe] (K_i = 0.45 nM).

Bioorganic & Medicinal Chemistry Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Name: 2-Chloro-4-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ning, Xiaoqin published the artcilePalladium-Catalyzed Carbene Coupling Reactions of Cyclobutanone N-Sulfonylhydrazones, SDS of cas: 939-99-1, the publication is Organic Letters (2021), 23(21), 8348-8352, database is CAplus and MEDLINE.

Described herein are the palladium-catalyzed cross-coupling reactions of cyclobutanone-derived N-sulfonylhydrazones with aryl or benzyl halides, suggesting that the metal carbene process and β-hydride elimination can smoothly occur in strained ring systems. Structurally diversified products including cyclobutenes, methylenecyclobutanes, and conjugated dienes are selectively afforded in good to excellent yields. Preliminary success in asym. carbene coupling reactions in strained ring systems has been achieved, providing a promising route for the synthesis of enantioenriched four-membered-ring mols.

Organic Letters published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Yuan, Xue published the artcileDiscovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs), Safety of 2-Chloro-4-methylphenylboronic acid, the publication is Journal of Medicinal Chemistry (2022), 65(13), 9312-9327, database is CAplus and MEDLINE.

Receptor-interacting serine/threonine protein kinase 2 (RIPK2) has been demonstrated to be a promising target for treating inflammatory diseases. Herein, we describe the discovery and optimization of a series of RIPK2 inhibitors derived from an FLT3 inhibitor, CHMFL-FLT3-165. Compound 10w (I) was identified to possess an IC₅₀ value of 0.6 nM for RIPK2 and greater than 50,000-fold selectivity over its family homologous kinase RIPK1 (IC₅₀ > 30μM). It exhibited high kinase selectivity and inhibited RIPK2 to prevent NOD-induced cytokine production following muramyl dipeptide (MDP) stimulation. In an acute colitis model, compound 10w exerted better therapeutic effects than the JAK inhibitor filgotinib and the RIPK2 inhibitor WEHI-345. These robust results of in vitro and in vivo pharmacodynamic experiments demonstrate that RIPK2 as a therapeutic target shows potential abilities for the treatment of inflammatory bowel diseases.

Journal of Medicinal Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C4H7BrO2, Safety of 2-Chloro-4-methylphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Qian published the artcileUnified synthesis of mono/bis-arylated phenols via Rh^III-catalyzed dehydrogenative coupling, Application In Synthesis of 209919-30-2, the publication is Chemical Science (2017), 8(1), 169-173, database is CAplus and MEDLINE.

A general strategy that allowed for the precise control of the oxidation pathways so that directing groups can be either preserved or cleaved was reported. It was found that N-phenoxyacetamides underwent ortho-arylation reactions with or without an external oxidant, yielding products with different oxidation states, notably the rare bis-arylated phenols. Notably, a unique rhodacycle intermediate was isolated, characterized by X-ray crystallog. and confirmed to be an active catalyst. Switching between internal and external oxidation could be a general strategy in diverse directed C-H functionalization reactions to realize bis-functionalized products.

Chemical Science published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C11H8O3, Application In Synthesis of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jin, Hao published the artcileTransition-Metal-Free, General Construction of Thioamides from Chlorohydrocarbon, Amide and Elemental Sulfur, SDS of cas: 939-99-1, the publication is European Journal of Organic Chemistry (2021), 2021(23), 3403-3406, database is CAplus.

A general method for one-pot synthesis of thioamides is developed through a three-component reaction involving chlorohydrocarbon, amide and elemental sulfur. Such a strategy does not only avoid residual transition metal in the product but also prevent the generation of C-N coupling byproduct. The latter is prone to be generated when alkane halide and amine are present. With the protocol proposed in this work, both alkyl and aryl thioamides can be obtained in moderate to excellent yields with a high tolerance of various functional groups. External oxidants are not required in the reaction. In addition, the reaction mechanisms are addressed using a combination of controlling experiments and quantum chem. calculations

European Journal of Organic Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, SDS of cas: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhao, Yan published the artcileAdaptability of different nebulizer systems to different silicon chemical forms for gasoline in inductively coupled plasma optical emission spectrometry, Category: chlorides-buliding-blocks, the publication is Guangpuxue Yu Guangpu Fenxi (2016), 36(10), 3303-3307, database is CAplus and MEDLINE.

Silicon is not a natural component of gasoline but it can cause silica deposition in vehicle combustion system which may lead to severe engine failure. Silicon is present in gasoline in different chem. forms. The anal. of oil products by directly measuring under organic phase through inductively coupled plasma optical emission spectrometry (ICP-OES) is becoming a widely accepted approach as it is found to be simple and fast. The work focused on the influence of the sample nebulizer systems to different silicon chem. forms by ICP-OES. For a sample introduction system consisting of micronebulizer coupled to a cyclonic spray chamber, the results indicated that the ICP-OES signals depended strongly on the silicon chem. forms, and the higher emission intensities were attributed to the compound volatility. The variability of the signals induced by the different silicon compounds was less significant for the same nebulizer system with a temperature control device. Nevertheless, the interferences were not effectively mitigated. Nevertheless, direct injection high efficiency nebulizer (DIHEN) introduced in the present work could effectively mitigate the interferences of different silicon chem. forms, was suitable for the determination of silicon in gasoline. The quant. method with the potential DIHEN nebulizer system showed good linearity and the recoveries ranged from 92.8%-108.7%, the limit of detection was 0.05 mg·kg^-1. The relative standard deviation (RSD) was between 1.05% and 4.63%. Compared with the microwave digestion method, the proposed method was found to be highly simple, rapid, sensitive and accurate, which was foreseen a promising application for silicon determination in gasoline.

Guangpuxue Yu Guangpu Fenxi published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C3H5BN2O2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Xiaoguang published the artcileCopper-Catalyzed γ-Sulfonylation of α,β-Unsaturated Carbonyl Compounds by Means of Silyl Dienol Ethers, Computed Properties of 21286-54-4, the publication is Organic Letters (2015), 17(14), 3572-3575, database is CAplus and MEDLINE.

γ-Sulfonyl-α,β-unsaturated ketones such as I [R = Ph, 4-MeC₆H₄, 4-O₂NC₆H₄, 2,4,6-R¹₃C₆H₂, F₅C₆, 8-quinolinyl, Me, i-Pr, ClCH₂CH₂, cyclopropyl, (1S)-10-camphorsulfonyl; R¹ = Me, i-Pr; R² = H] were prepared regioselectively by reaction of dienyl silyl ethers such as II (TBDMS = tert-butyldimethylsilyl) with sulfonyl chlorides RSO₂Cl [R = Ph, 4-MeC₆H₄, 4-O₂NC₆H₄, 2,4,6-R¹₃C₆H₂, F₅C₆, 8-quinolinyl, Me, i-Pr, ClCH₂CH₂, cyclopropyl, (1S)-10-camphorsulfonyl; R¹ = Me, i-Pr] in the presence of CuCl in MeCN. Selected sulfonylated unsaturated ketones underwent regioselective alkylation and Michael addition reactions and cyclocondensations to yield products such as I (R = Ph; R² = Me, MeO₂CCH₂CH₂).

Organic Letters published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Computed Properties of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Xianfeng published the artcileDesign and Synthesis of Orally Bioavailable Aminopyrrolidinone Histone Deacetylase 6 Inhibitors, Recommanded Product: Methyl 4-bromo-3-chlorobenzoate, the publication is Journal of Medicinal Chemistry (2015), 58(6), 2809-2820, database is CAplus and MEDLINE.

Histone deacetylase 6 (HDAC6) removes the acetyl group from lysine residues in a number of non-histone substrates and plays important roles in microtubule dynamics and chaperone activities. There is growing interest in identifying HDAC6-selective inhibitors as chem. biol. tools and ultimately as new therapeutic agents. Herein we report the design, synthesis, and phenotypic screening of a novel class of 3-aminopyrrolidinone-based hydroxamic acids as HDAC6 inhibitors. In particular, the α-methyl-substituted enantiomer I (3-S) showed significant in-cell tubulin acetylation (Tub-Ac) with an EC₅₀ of 0.30 μM but limited impact on p21 levels at various concentrations In enzyme inhibition assays, I demonstrated high selectivity for HDAC6 with an IC₅₀ of 0.017 μM and selectivity indexes of 10 against HDAC8 and over 4000 against HDAC1-3 isoforms. Moreover, I has suitable drug metabolism and pharmacokinetics properties compared with other hydroxamic acid-based HDAC inhibitors, warranting further biol. studies and development as a selective HDAC6 inhibitor.

Journal of Medicinal Chemistry published new progress about 117738-74-6. 117738-74-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Ester, name is Methyl 4-bromo-3-chlorobenzoate, and the molecular formula is C8H6BrClO2, Recommanded Product: Methyl 4-bromo-3-chlorobenzoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics