Month: December 2022

Xiao, Chunsheng published the artcileSide chain impacts on pH- and thermo-responsiveness of tertiary amine functionalized polypeptides, SDS of cas: 4584-49-0, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2014), 52(5), 671-679, database is CAplus.

The systemic investigation of the structural impacts of side chains on the pH- and thermo-responsiveness of tertiary amine functionalized poly(L-glutamate)s (TA-PGs) was carried out. The TA-PGs polymers were effectively synthesized by Cu(I)-catalyzed azide-alkyne cycloaddition click reaction of azido tertiary amines with poly(γ-propargyl-L-glutamate) (PPLG). Turbimetric measurements were performed to characterize the pH- and temperature-induced phase transition of TA-PGs in aqueous solution, which suggested a structural dependence of the properties on the N-substituted groups and the “linkers” between 1,2,3-triazole ring and the tertiary amine groups in the side chains. In detail, the pH responsive properties of TA-PGs were basically determined by the hydrophobicity of the N-substituted groups in the side chains and the pH transition point (pH_t) decreased as the increasing hydrophobicity of the N-substituted groups, while the temperature-responsiveness of TA-PGs were affected by either the N-substituted groups or the “linkers.” TA-PGs with a moderate N-substituted amine group (e.g., DEA, PR, and PD) or a branched “linker” (e.g., iso-propylene and 2-methylpropylene group) were more likely to express the LCST-type phase transition tuned by pH variation. These structure-property relationships revealed in this study would help to develop the applications of TA-PGs in smart drug delivery systems. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C7H5ClN2S, SDS of cas: 4584-49-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Dachuan published the artcileDesign, synthesis and biological evaluation of benzo[d]thiazole with dimethylpyrazole derivatives, COA of Formula: C8H6ClF3, the publication is Asian Pacific Journal of Cancer Prevention (2019), 20(11), 3487-3495, database is CAplus and MEDLINE.

A series of new benzothiazole derivatives containing dimethylpyrazole I [R = H, n-pentyl, benzyl, etc.] were synthesized and evaluated for their anticonvulsant activity, neurotoxicity and cytotoxicity by using the maximal electroshock (MES), rotarod neurotoxicity (TOX) and MTT colorimetric assay. Among the compounds studied, four compounds I [R = Bu, n-pentyl, 2-fluorobenzyl, 2,6-dichlorobenzyl] showed better anticonvulsant than the others at 300 mg/kg and they also showed anticonvulsant activity at the dose of 100 mg/kg. All the synthetic compounds I showed lower neurotoxicity and little cytotoxicity, so that the compounds, which with better activities, also had higher protective index. In particular, the compound I [R = 2-fluorobenzyl] showed better activity with an ED₅₀ value of 160.4 mg/kg and higher protective index (PI) values of 2.74 in the MES test than the standard drugs sodium valproate, which used as pos. controls in this study. After that the compound I [R = 2-fluorobenzyl] demonstrated antagonistic activity against seizures induced by pentylenetetrazol, which proved compound I [R = 2-fluorobenzyl] may be exert activity through effecting GABAergic neurotransmission.

Asian Pacific Journal of Cancer Prevention published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, COA of Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Dachuan published the artcileDesign, synthesis and biological evaluation of benzo[d]thiazole with dimethylpyrazole derivatives, Safety of 3-Chlorobenzylchloride, the publication is Asian Pacific Journal of Cancer Prevention (2019), 20(11), 3487-3495, database is CAplus and MEDLINE.

A series of new benzothiazole derivatives containing dimethylpyrazole I [R = H, n-pentyl, benzyl, etc.] were synthesized and evaluated for their anticonvulsant activity, neurotoxicity and cytotoxicity by using the maximal electroshock (MES), rotarod neurotoxicity (TOX) and MTT colorimetric assay. Among the compounds studied, four compounds I [R = Bu, n-pentyl, 2-fluorobenzyl, 2,6-dichlorobenzyl] showed better anticonvulsant than the others at 300 mg/kg and they also showed anticonvulsant activity at the dose of 100 mg/kg. All the synthetic compounds I showed lower neurotoxicity and little cytotoxicity, so that the compounds, which with better activities, also had higher protective index. In particular, the compound I [R = 2-fluorobenzyl] showed better activity with an ED₅₀ value of 160.4 mg/kg and higher protective index (PI) values of 2.74 in the MES test than the standard drugs sodium valproate, which used as pos. controls in this study. After that the compound I [R = 2-fluorobenzyl] demonstrated antagonistic activity against seizures induced by pentylenetetrazol, which proved compound I [R = 2-fluorobenzyl] may be exert activity through effecting GABAergic neurotransmission.

Asian Pacific Journal of Cancer Prevention published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Safety of 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Duan, Cancan published the artcilePharmacokinetics and tissue distribution of cantharidin after oral administration of aqueous extracts from Mylabris in rats, Formula: C12H15ClO3, the publication is Biomedical Chromatography (2021), 35(10), e5172, database is CAplus and MEDLINE.

A sensitive gas chromatog.-mass spectroscopy method was established for the determination of cantharidin (CTD) in rat plasma and liver homogenates. During the experiment, rats were randomly divided into two groups (low, high) and were administered aqueous extract of Mylabris compound for 7 days. Then, plasma and tissue samples were taken at different time points to study the pharmacokinetics and tissue distribution of CTD in rats. The selected reaction monitoring transitions for CTD and clofibrate (internal standard) were m/z 128 → 85 and m/z 169 → 141, resp. The calibration curve ranged from 10.26 to 3,078 ng/mL for plasma and from 10.26 to 246.24 ng/mL for liver homogenates. The lower limits of quantification were 10.26 ng/mL for both plasma and liver. The intra- and inter-day precision and accuracy were <20% for both plasma and liver homogenates. Extraction recovery ranged from 89.21 to 103.61% for CTD in rat plasma and liver and from 83.79 to 102.74% for IS in rat plasma and liver. Matrix effects ranged from 93.06 to 110.44% for CTD and from 91.65 to 110.80% for IS.

Biomedical Chromatography published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Formula: C12H15ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hsu, Li-Na published the artcileCentral action of drugs for treatment of hypertension. I. Effect of reserpine on the conditioned response and blood pressure of normal dogs, Category: chlorides-buliding-blocks, the publication is Shengli Xuebao (1961), 24(3-4), 151-60, database is CAplus.

In 7 normal dogs given reserpine orally at 0.005-0.03 mg./kg. for 4-15 days, the positive conditioned response decreased and the reinforcement relation changed, sometimes with change in phase. The effect on the delayed conditioned response depends on dosage. A large dose (0.25 mg./kg.) seriously upset the equilibrium in stimulation-depression mechanisms to cause a nervous condition. With a daily dose of 0.005 or 0.01 mg./kg., no change in blood pressure was observed, but a change in conditioned response was quite distinct. This indicates that the cerebral cortex is more sensitive to resperine than the midbrain. It also indicates that the change in response is not induced by the action of resperine on the vasomotor center.

Shengli Xuebao published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chu, Haoke published the artcileAsymmetric Dearomatization of Indole by Palladium/PC-Phos-Catalyzed Dynamic Kinetic Transformation, Synthetic Route of 1451393-45-5, the publication is Angewandte Chemie, International Edition (2020), 59(49), 21991-21996, database is CAplus and MEDLINE.

A palladium-catalyzed intermol. dynamic kinetic asym. dearomatization of 3-arylindoles with internal alkynes was developed with the use of achiral Xantphos and chiral sulfinamide phosphine ligand (PC-Phos) as the co-ligands. This method could deliver various spiro[indene-1,3′-indole] compounds in good yields (up to 95% yield) with up to 98% ee. The salient features of the transformation include the use of readily available substrates, ease of scale-up and the versatile functionalization of the products. The mechanistic experiments gave some insights on active intermediates.

Angewandte Chemie, International Edition published new progress about 1451393-45-5. 1451393-45-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (2-Bromo-4-chlorophenyl)boronic acid, and the molecular formula is C6H5BBrClO2, Synthetic Route of 1451393-45-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Froneman, M. published the artcileDialkylamino group transfer from titanium(IV) to a phosphoryl center. Structure-reactivity studies, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1990), 47(3-4), 273-81, database is CAplus.

Reaction between phosphoryl substrates (EtO)₂P(O)R (R = H, Me, OEt) and Ti(NR₂)_nCl_4-n (R¹ = Me, Et, n = 2, 3, 4) and Mn(NEt₂)₂ leads to the exchange of one or both EtO groups for the NR₂ substituent. The reactivity of the system depends on electronic as well as steric effects of both substrates, and approx. correlates with Lewis acid-base interactions between the substrates.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wan, Zhao-Kui published the artcileEfficacious 11β-Hydroxysteroid Dehydrogenase Type I Inhibitors in the Diet-Induced Obesity Mouse Model, Name: 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, the publication is Journal of Medicinal Chemistry (2009), 52(17), 5449-5461, database is CAplus and MEDLINE.

Cortisol and the glucocorticoid receptor signaling pathway have been implicated in the development of diabetes and obesity. The reduction of cortisone to cortisol is catalyzed by 11β-hydroxysteroid dehydrogenase type I (11β-HSD1). 2,4-Disubsituted benzenesulfonamides were identified as potent inhibitors of both the human and mouse enzymes. The lead compounds displayed good pharmacokinetics and ex vivo inhibition of the target in mice. Cocrystal structures of compounds I and II bound to human 11β-HSD1 were obtained. Compound II was found to achieve high concentrations in target tissues, resulting in 95% inhibition in the ex vivo assay when dosed with a food mix (0.5 mg of drug per g of food) after 4 days. Compound II was efficacious in a mouse diet-induced obesity model and significantly reduced fed glucose and fasted insulin levels. Our findings suggest that 11β-HSD1 inhibition may be a valid target for the treatment of diabetes.

Journal of Medicinal Chemistry published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H11N, Name: 2-Chloro-4-cyanobenzene-1-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wan, Tianfeng published the artcileCovalent organic nanospheres modified magnetic nanoparticles for extraction of blood lipid regulators in water samples, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Journal of Separation Science (2021), 44(11), 2301-2309, database is CAplus and MEDLINE.

Covalent organic nanospheres are new kind of nanospherical polymer with large sp. surface area, uniform morphol., and excellent chem. and thermal stability. This material can be fabricated by a facile and rapid room temperature solution-phase strategy. In this work, magnetic nanoparticles were attached to the surface of covalent organic nanospheres, and the obtained composites were used for the extraction of blood lipid regulators such as clofibrate and fenofibrate. These composites were characterized with Fourier-transformed IR spectroscopy, XPS, and transmission electron microscopy. Several parameters that might affect the extraction efficiency including acetonitrile content, pH value, extraction time, and sample volume were investigated. Under optimum conditions, the proposed anal. method showed high extraction efficiency toward clofibrate and fenofibrate with enrichment factors between 60 and 83. This method exhibited outstanding anal. performance with wide linear range and excellent reproducibility and had low limits of detection in the range of 0.02-0.03 ng/mL. This method was also applied to the detection of clofibrate and fenofibrate in lake water samples, and good recoveries in the range of 92.6-112.6% was obtained.

Journal of Separation Science published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C15H14Cl2S2, Name: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lin, Shuangjie published the artcileVisible-light-driven spirocyclization of epoxides via dual titanocene and photoredox catalysis, HPLC of Formula: 21286-54-4, the publication is Chemical Science (2020), 11(3), 839-844, database is CAplus and MEDLINE.

The synergistic utilization of titanocene/photoredox dual catalysis driven by visible light for the radical opening/spirocyclization of easily accessible epoxyalkynes. This environmentally benign process used organic donor-acceptor fluorophore 2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile as a photocatalyst and Hantzsch ester as an electron donor instead of stoichiometric metallic reductants. The photocatalytic conditions showed exceptionally high reactivity for the synthesis of privileged and synthetically challenging spirocycles, e.g., I, featuring a spiro all-carbon quaternary stereocenter. Cyclic voltammetry studies suggest that Cp₂TiIIICl is the catalytically active species.

Chemical Science published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, HPLC of Formula: 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics