Month: December 2022

Nagiev, Kh. D. published the artcilePhotometric determination of Mo(VI) by pyrogallol derivatives in the presence of a third component, Related Products of chlorides-buliding-blocks, the publication is Zavodskaya Laboratoriya, Diagnostika Materialov (2003), 69(10), 15-19, database is CAplus.

The complex formation of Mo(VI) with pyrogallol derivatives in the presence of a 3rd component is studied photometrically. Amines, especially ethylenediamine, and benzidine, and surfactants, especially cetylpyridinium chloride, and decametoxin, were used as 3rd components. The optimal requirements for binary Mo(VI) complex formations and their basic spectro-photometric parameters were determined The method is applied to determine micro quantities of molybdenum in tap water, soil of the Apsheron peninsula and in different kinds of steels.

Zavodskaya Laboratoriya, Diagnostika Materialov published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Heo, Seunga published the artcileBoosting photoredox catalysis using two-dimensional electride as persistent electron donor, Formula: C8H6ClF3, the publication is ACS Applied Materials & Interfaces (2021), 13(36), 42880-42888, database is CAplus and MEDLINE.

Electrides, which have excess anionic electrons, are solid-state sources of solvated electrons that can be used as powerful reducing agents for organic syntheses. However, the abrupt decomposition of electrides in organic solvents makes controlling the transfer inefficient, thereby limiting the utilization of their superior electron-donating ability. Here, we demonstrate the efficient reductive transformation strategy which combines the stable two-dimensional [Gd₂C]²⁺·2e^– electride electron donor and cyclometalated Pt(II) complex photocatalysts. Strongly localized anionic electrons at the interlayer space in the [Gd₂C]²⁺·2e^– electride are released via moderate alcoholysis in 2,2,2-trifluoroethanol, enabling persistent electron donation. The Pt(II) complexes are adsorbed onto the surface of the [Gd₂C]²⁺·2e^– electride and rapidly capture the released electrons at a rate of 10⁷ s^-1 upon photoexcitation. The one-electron-reduced Pt complex is electrochem. stable enough to deliver the electron to substrates in the bulk, which completes the photoredox cycle. The key benefit of this system is the suppression of undesirable charge recombination because back electron transfer is prohibited due to the irreversible disruption of the electride after the electron transfer. These desirable properties collectively serve as the photoredox catalysis principle for the reductive generation of the benzyl radical from benzyl halide, which is the key intermediate for dehalogenated or homocoupled products.

ACS Applied Materials & Interfaces published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Formula: C8H6ClF3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Freidlina, R. Kh. published the artcileThermal telomerization of olefins with silanes, Application In Synthesis of 14799-94-1, the publication is Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya (1960), 662-8, database is CAplus.

cf. CA 52, 6165d. Heating 11.5 g. MeSiHCl₂ and 4.3 g. C₂H₄ in an ampul in an autoclave 3 hrs. at 320-40° gave mixed MeEtSiCl₂ and MeBuSiCl₂ in yields of 42-80% and 17-28%, resp. The use of a bare steel autoclave tended to lower the yield of MeEtSiCl₂ and raise that of BuMeSiCl₂. Similarly, Ph₃SiH and C₂H₄ in hexane 12 hrs. at 300° gave Ph₃SiEt, m. 68-70°, and Ph₃SiBu, m. 81-2°, along with some (Ph₃Si)₂O, m. 224°. Reaction of MeSiHCl₂ and propylene in the presence of a catalytic amount of H₂PtCl₆ in iso-PrOH in 1 hr. at room temperature gave MePrSiCl₂, which with MeMgBr gave known Me₃SiPr. In the telomerization of MeSiHCl₂ with C₂H₄ at 300°, the increased proportion of the olefin tended to lower steadily the yield of MeSiCl₂Et and MeSiCl₂(CH₂CH₂)₂H, while the yield of MeSiCl₂(CH₂CH₂)₃H remained substantially constant and that of MeSiCl₂(CH₂CH₂)₃H rose rapidly. Elevation of the temperature from 285° to 350° increased the yield of MeSiCl₂Et and decreased that of telomers with n over 3, while the intermediate telomer yield remained substantially constant

Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Application In Synthesis of 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Curtis, Michael P. published the artcileThe discovery of isoxazoline oxime ethers as a new class of ectoparasiticides for the control of Haematobia irritans (horn fly) in cattle, Quality Control of 864725-22-4, the publication is Bioorganic & Medicinal Chemistry Letters (2014), 24(21), 5011-5014, database is CAplus and MEDLINE.

Hematobia irritans (horn fly) infestation in cattle is responsible for over a billion dollars a year in global economic loss due to decreased milk production and lower feed conversion. There is significant need for new insecticidal agents since current treatments such as organophosphates and pyrethroids suffer from field resistance. Isoxazoline oxime ethers represent a new class of γ-aminobutyric acid (GABA) receptor channel blockers which show good activity (LD⁹⁰ = 1.0 μg/mL) against horn flies in an in vitro feed assay and have demonstrated efficacy (>90% reduction at 1.0 mg/kg) as a topical treatment in a field study.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Quality Control of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fan, Ao published the artcilePhosphonium ionic liquids as highly thermal stable and efficient phase transfer catalysts for solid-liquid Halex reactions, SDS of cas: 350-30-1, the publication is Catalysis Today (2012), 198(1), 300-304, database is CAplus.

Trihexyl (tetradecyl) phosphonium tetrafluoroborate was found to be an active catalyst for the introduction of fluoride by nucleophilic aromatic substitution. With a decomposition temperature above 300 °C, this ionic liquid is suitable for reactions at high temperatures The addition of 1 mol% of the ionic liquid relative to KF increased the initial rate for the fluorination of 1,2-dichloro-4-nitrobenzene six-fold compared to the uncatalyzed reaction. The highest reaction rate was observed at 20 mol% ionic liquid relative to KF. Ease of handling without the need for stringent drying conditions and reuseability make this ionic liquid a useful phase transfer catalyst.

Catalysis Today published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, SDS of cas: 350-30-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xu, Peng published the artcileNovel promising 4-anilinoquinazoline-based derivatives as multi-target RTKs inhibitors: Design, molecular docking, synthesis, and antitumor activities in vitro and vivo, Quality Control of 939-99-1, the publication is Bioorganic & Medicinal Chemistry (2019), 27(20), 114938, database is CAplus and MEDLINE.

4-Anilinoquinazoline derivatives I [R = 2-OBn, 3-OBn, 4-OBn, 2-O(4-NO₂Bn), etc.; n = 0, 1, 2] were designed and synthesized using a binding model with multi-target receptor tyrosine kinases and assessed their antitumor activity against five human tumor cell lines (HepG2, A549, MCF-7, DU145, SH-SY5Y). The majority of the compounds inhibited the proliferation of all the cancer cell types, with some compounds displaying selective inhibition. Compounds I [R = 3-OBn, n = 0], I [R = 4-O(4-NO₂Bn), n = 0] and I [R = 2-OBn, n = 1] displayed IC₅₀ values of 7.588, 8.619 and 6.936μM, resp., for A549 cells, which were much lower than that of Gefitinib (14.803μM). Compound I [R = 3-O(4-CF₃Bn), n = 1] displayed an IC₅₀ value of 2.756μM for DU145 cells. The representative compound I [R = 3-O(4-CF₃Bn), n = 1] had unexceptionable broad-spectrum inhibition for all cancer cell types, and demonstrate inhibition of vascular endothelial growth factor receptor 2 (VEGFR-2), platelet-derived growth factor receptor beta (PDGFR-β), and epidermal growth factor receptor (EGFR) with IC₅₀ values of 46.4, 673.6 and 384.8 nM, resp., which were similar to those of Sorafenib for VEGFR-2 and PDGFR-β (140.6 and 582.7 nM, resp.). Mol. docking results supported the mol. level assay results. Data for production of reactive oxygen species and assessment of matrix metalloproteinase corroborated the strong anti-proliferative effect of compound I [R = 3-O(4-CF₃Bn), n = 1]. The compound also displayed robust antitumor efficacy and relativity lower toxicity in a xenograft model. These attributes were similar to those of Sorafenib.

Bioorganic & Medicinal Chemistry published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H15NO, Quality Control of 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Baj, Stefan published the artcileNew and efficient technique for the synthesis of ε-caprolactone using KHSO₅ as an oxidizing agent in the presence of a phase transfer catalyst, Quality Control of 23616-79-7, the publication is Applied Catalysis, A: General (2011), 395(1-2), 49-52, database is CAplus.

A new method for the synthesis of ε-caprolactone based on the Baeyer-Villiger oxidation of cyclohexanone was developed. In the proposed reaction, potassium peroxomonosulfate was used as an oxidizing agent under phase transfer catalysis conditions. The effects of the reaction parameters, including the type of phase transfer catalyst, the concentration of the oxidizing agent, the type of organic solvent and temperature, were investigated. When dichloromethane was used as an organic solvent and an adequate amount of water was added to the reaction mixture, the highest yield and selectivity for ε-caprolactone were achieved at 40°.

Applied Catalysis, A: General published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Quality Control of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Carle, Joergen S. published the artcileDogger Bank itch. The allergen is (2-hydroxyethyl)dimethylsulfoxonium ion, Formula: C3H9ClOS, the publication is Journal of the American Chemical Society (1980), 102(15), 5107-8, database is CAplus.

The causative agent of Dogger Bank Itch, an allergic contact dermatitis caused by exposure to Alcyonidium gelatinosum, was characterized and synthesized. This allergen is (2-hydroxyethyl)dimethylsulfoxonium ion.

Journal of the American Chemical Society published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Formula: C3H9ClOS.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wall, Joseph S. published the artcileSpectrophotometric determination of betaines and other quaternary compounds as their periodides, HPLC of Formula: 6249-56-5, the publication is Anal. Chem. (1960), 870-4, database is CAplus.

The method of Appleton, et al. (CA 48, 3437a), for the determination of choline, through the absorbance of its periodide at 365 mμ, was modified for the determination of other quaternary N compounds (e.g. betaine, trigonelline, carnitine, stachydrine, and γ-butyrobetaine) as each was separated from an extract of corn grain by ion-exchange chromatography (cf. following abstract). Certain N compounds (such as nicotinic acid, histidine, adenine, and thiamine), which give precipitates with I, may occur in some eluates but they do not interfere in this method. As many as 50 tubes of anal. samples containing 10-100 γ of a compound can be handled. The roles of pH, I concentration, temperature, time, and presence of chloride ions on the yield of the isolated periodide were studied.

Anal. Chem. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C4Br2N2O4S, HPLC of Formula: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jahan, Humera published the artcileAnthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes, Computed Properties of 60091-87-4, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2018), 14(5), 516-523, database is CAplus and MEDLINE.

Anthranilic acid derivatives are important pharmacophores in drug discovery. Several of them are currently being used, such as mefenamic acid and meclofenamates, possess analgesic, anti-inflammatory and antipyretic activities. Some anthranilic acid-based scaffolds have also been reported for the management of metabolic disorders. The aim of the current study was to investigate the antiglycation potential of 2-anilino benzoic acid derivatives against (N-phenylanthranilic acid) fructose- human serum albumin (HSA) glycation. The study also analyzed the effects of newly identified antiglycation inhibitors on AGEs-mediated intracellular reactive oxygen species production, and associated impaired proliferation of the hepatocytes. The present study focuses on the antiglycation activity of 2- anilinobenzoic acid derivatives 1-18 in in-vitro human serum albumin (HSA)- fructose model. These derivatives were also identified as non-toxic to 3T3 mouse fibroblast cell-line using metabolic assay. The effect of the most promising derivative 1, 2- (2, 4- dinitroanilino)benzoic acid, was studied in a dose dependent manner, co-incubated with fructose-derived AGEs (0- 200 μg/mL), on rat hepatocytes proliferation and associated intracellular generation of ROS via MTT assay and DCFH-DA technique, resp. We found that derivative 1 ameliorates the elevated intracellular oxidative stress and associated diminished proliferation of the hepatocytes in response to AGEs. In conclusion, we identify novel 2- anilino benzoic acid derivatives as antiglycation agents through in-vitro and cellular-based models.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Computed Properties of 60091-87-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics