Month: December 2022

Paolino, D. published the artcilePolyaspartylhydrazide copolymer-based supramolecular vesicular aggregates as delivery devices for anticancer brugs, Quality Control of 6249-56-5, the publication is Biomacromolecules (2008), 9(4), 1117-1130, database is CAplus and MEDLINE.

In this paper we report on three different hydrophilic copolymers based on α,β-polyaspartylhydrazide (PAHy) bearing butyric groups in the side chain (C₄) (PAHy-C₄) or a combination of butyric groups and pos. charged residues ((carboxypropyl)trimethylammonium chloride, CPTACl) (PAHy-C₄-CPTA) that were synthesized and used for the preparation of new supramol. vesicular aggregates (SVAs) containing gemcitabine as an antitumor drug. Gemcitabine-loaded SVAs containing synthesized PAHy derivatives were characterized from the physicochem. and technol. point of view and the in vitro toxicity and anticancer activity on two different human cancer cell lines, i.e., CaCo-2 (human colon carcinoma) and ARO (human anaplastic thyroid carcinoma) cells, were also evaluated. Moreover, considering that carrier-cell interaction is an important factor to achieve an improvement of anticancer drug activity, confocal laser scanning microscopy and flow cytometric experiments were carried out on the two different cancer cell lines.

Biomacromolecules published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Quality Control of 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lahm, George P. published the artcile4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(10), 3001-3006, database is CAplus and MEDLINE.

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biol. activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides e. g., I.

Bioorganic & Medicinal Chemistry Letters published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Application of 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Childress, Scott J. published the artcileElectronegative substitutions in local anesthetics of the benzoic acid ester type, Computed Properties of 5204-46-6, the publication is Journal of the American Chemical Society (1954), 3988-91, database is CAplus.

A series of substituted BzOH esters of various alkanolamines has been prepared and tested pharmacologically. Esters of the tertiary amino alcs. were prepared either by the condensation of the corresponding dialkylaminoalkyl chloride with the Na salt of the acid (method A) or by the condensation of the acid chloride with the amino alc. in the presence of excess base (method B). The esters of secondary amines were prepared by refluxing the HCl salt of the secondary amino alc. with the acid chloride (method C). The nitro esters were reduced to the amino esters by treating the HCl salts with Fe powder in H₂O or aqueous EtOH (method D). The topical and intradermal anesthetic activities of the resulting esters were measured on guinea pig wheal and rabbit cornea, resp.; comparisons were made with cocaine or procaine, to each of which the value 1 was assigned; the acute toxicities were determined in albino mice. Me₃CNH₂ (37 g.), 22 g. ethylene oxide, and 2 cc. MeOH refrigerated 3 days and the mixture fractionated gave 6.5 g. Me₃CNH(CH₂)₂OH, b. 176-7°; picrate, m. 159-60° (from H₂O). 2,4-Cl(H₂N)C₆H₃CO₂H (34.3 g.), 30 g. BuBr, and 13.2 g. KOH in 250 cc. 75% EtOH refluxed overnight, the mixture treated with 13.2 g. KOH and 30 g. BuBr, refluxed 8 hrs., concentrated in vacuo, made basic with KOH, extracted with Et₂O, and acidified, the solid precipitate (20 g.) extracted with 3 l. boiling H₂O, the solution let stand, the procedure repeated with the mother liquor, and the resulting crystals recrystallized 3 times from 95% EtOH yielded 7.5 g. 2,4-Cl(BuNH)C₆H₃CO₂H (I), white crystals, m. 112-14°; the residue from the H₂O extraction recrystallized twice from absolute EtOH gave 2,4-Cl(Bu₂N)C₆H₃CO₂H, white crystals, m. 127-9°. 2,6,4-Cl₂(O₂N)C₆H₂Me (12 g.) in 50 cc. pyridine and 40 cc. H₂O, the mixture heated to the b.p., treated at intervals with six 4.3-g. portions KMnO₄, and filtered, the filtrate concentrated in vacuo to 1/4 its original volume and treated with concentrated HCl, the precipitate dissolved in aqueous NaOH to remove 6 g. unreacted material, the solution acidified, and the yellow crystalline precipitate (2 g.) repeatedly recrystallized from H₂O and dried gave 2,6,4-Cl₂(O₂N)C₆H₂CO₂H (II), white crystals, m. 172-4° with sintering at 157°. II (7 g.) refluxed 4 hrs. with 25 g. SOCl₂, and the resulting crude acid chloride treated with EtOH gave a poor yield of the Et ester, but yielded some anhydride of II, yellow needles, m. 190-1.5° (from EtOH). II (1.9 g.) and 1.5 g. 5% Pd-C added to 60 cc. MeOH, the mixture treated with stirring during 5 min. with 1 g. N₂H₄ in 5 cc. MeOH, let stand over the weekend, filtered, concentrated to 10 cc., poured into 25 cc. H₂O, and acidified, and the precipitate recrystallized twice from H₂O yielded 0.4 g. 2,6,4-Cl₂(H₂N)C₆H₂CO₂H (III), cream-colored crystals, m. 178-9° (decomposition). The following alkyl ester of ο-ClC₆H₄CO₂H HCl salts [alkyl group, m.p., method of preparation, local anesthetic activity compared to cocaine (topical) and procaine (intradermal), and the subcutaneous and the intravenous LD₅₀ in mg./kg. given] were prepared: Et₂N(CH₂)₂, 127-8° (from 95% EtOH), A, 0, 0.4, >1000, 120; Me₂CHCH₂NH(CH₂)₂, 141-2° (from EtOH-Et₂O), C, 0, 1.5, >1000, 75; EtMeCHNH(CH₂)₂, 181-3° (95% EtOH), C, 0, 1.2, >1000, 91; β-cyclohexylaminoethyl, 203-5° (from 50% EtOH), C, 0.3, 1,2, >1000, 98; β-cyclohexylaminoisopropyl, 174-5°, C, 1.7, 1.1, 250, 36. The following ester HCl salts of 3,4-Cl₂C₆H₄CO₂H (same data given): Et₂N(CH₂)₂, 178.5-80° (from EtOAc-EtOH), B, 0, 0.6, 840, 84; EtMeCHNH(CH₂)₂, 180-2° (from 95% EtOH), C, 0.3, 0.8, 510, 120. The following ester HCl salts of 2,4-Cl(O₂N)C₆H₃CO₂H (m.p. and method given): Et₂NCHMeCH₂, 150.5-2.5°, B; Et₂NCH₂CHMe, 145-8° (from EtOH-Et₂O), B; Et₂N(CH₂)₃, 125-6° (from EtOH-Et₂O), B; Me₂CHNH(CH₂)₂, 188-9°, C; BuNH(CH₂)₂, 162-3.5°, C; Me₂CHCH₂NH(CH₂)₂, 172-4°, C; EtMeCHNH(CH₂)₂, 160-1°, C; Me₃CNH(CH₂)₂, 190-2°, C; Et₂CHNH(CH₂)₂, 162-4°, C; BuNH(CH₂)₃, 140-1°, C; EtMeCHNH(CH₂)₃, 160-3°, C; β-cyclohexylaminoethyl, 177-8°, C; 2-cyclohexylamino-1-propyl, 179-80.5°, C; 1-cyclohexyl-2-propyl, 171-2.5°, C; β-cyclohexylaminoisopropyl, 182.5-84°, C; 2-cyclohexylamino-1-phenylethyl, 196-8°, C. 2,4-Br(O₂N)C₆H₃CO₂(CH₂)₂NHCHEtMe.HCl, 157-8°, C. 2,4-(O₂N)₂C₆H₃CO₂(CH₂)₂NEt₂, 137-9° (from EtOH-Et₂O), B (all nitro esters, except where otherwise stated, were recrystallized from EtOH). The following alkyl ester HCl salts of 2,4-Cl(H₂N)C₆H₃CO₂H (all by method D) (alkyl group, m.p., activity, and toxicity given): Et₂NCHMeCH₂, 156.5-7.5° (from EtOH-EtOAc), 1.1, 2.2, 240, 44; Et₂NCH₂CHMe, 156-7°, 1.3, 3.1, 220, 55; Et₂N(CH₂)₃, 198.5-9.5°, 2.9, 2.5, 205, 50; Me₂CHNH(CH₂)₂(HCO₂H salt), 163-5°, 0.9, 1.0, 900, 84; BuNH(CH₂)₂, 161-3°, 0.9, 6.0, 320, 47; Me₂CHCH₂NH(CH₂)₂, 215-17°, 1.3, 4.4, 260, 50; EtMeCHNH(CH₂)₂, 195.5-97°, 2.6, 4.1, 570, 45; (HCO₂H salt), 152-2.5°, 2.3, 4.9, 670, 46) [0.5(CH₂CO₂H)₂ salt], 192-4°, -, 4.9, -, -]; Me₂CHNH(CH₂)₂, 270° (decomposition), 1.0, 1.0, 750, 63; Et₂CHNH(CH₂)₂(HCO₂H salt), 145-6.5°, 1.9, 1.3, 740, 37; BuNH(CH₂)₃, 168-70°, 1.8, 3.1, 140, 23; EtMeCH(CH₂)₃, 208-9.5°, 2.7, 1.4, 220, 29; β-cyclohexylaminoethyl, 224.5-26°, 2.4, 3.1, 280, 29; 2-cyclohexylaminopropyl (HCO₂H salt), 162.5-64°, 3.0, 2.1, 330, 24; β-cyclohexylamino-2-propyl, 159-61°, 3.4, 3.1, 57, 17; 3-cyclohexylaminoisopropyl, 188.5-9.5°, 2.2, 3.4, 120, 17; 2-cyclohexylamino-1-phenylethyl, 239-41° (decomposition), -, -, -, -; 2,4-Br(H₂N)C₆H₃CO₂(CH₂)₂NHCHEtMe, 202-4°, 2.5, 2.7, 450, 43. The following ester HCl salts of 4,2-H₂N(O₂N)C₆H₃CO₂H by method A (same data given): Et₂N(CH₂)₂, 177-9°, 0.2, 1.4, 850, 130; Et₂NCHMeCH₂, 182-5°, 0, 1.5, 800, 71; Et₂N(CH₂)₃, 221-3°, 0.5, 1.0, 430, 49. The following ester salts of I (same data given) by method A: Me₂N(CH₂)₂ HCl salt monohydrate, 84-6° (from EtOH-EtOAc), 0.1, 1.9, 1000, 72; Me₂N(CH₂)₂ di-HCl salt, 167-70° (decomposition), -, -, -, -; Et₂N(CH₂)₂ di-HCl salt, 151-4°, -, -, -, – (all previous ester salts were recrystallized from EtOH, except where otherwise indicated). The Et₂N(CH₂)₂ ester HCl salts of the following acids (m.p., method, activity, and toxicity given): 2,5-Cl(O₂N)C₆H₃CO₂H, 197-8° (from EtOH), B, -, -, -, -; 2,5-Cl(H₂N)C₆H₃CO₂H, 152.5-4.5° (from iso-PrOH), D, 0, 0.6, >1200, 110; 3,4-Cl(H₂N)C₆H₃CO₂H, 148-50° (from EtOH-EtOAc), A, 1.2, 0.7, >450, 45; II, 170-1° (from EtOH), A, -, -, -, -; III, 154-5.5° (from EtOH-EtOAc), D, 2.8, 3.5, 130, 31; 3,5,4-Cl₂(H₂N)C₆H₂CO₂H, 237-8° (from EtOH), A, 0.7, 2.0, 290, 44. The EtMeCHNH(CH₂)₂ ester HCl salts of the following acids (same data given): 2,5-Cl(O₂N)C₆H₃CO₂H, 158.5-9.5° (from EtOH), C, -, -, -, -; 2,5-Cl(H₂N)C₆H₃CO₂H, 121-3° (from iso-PrOH), D, 0, 2.0, >1200, 75; 3,4-Cl(O₂N)C₆H₃CO₂H, 174-5° (from EtOH), C, -, -, -, -; 3,4-Cl(H₂N)C₆H₃CO₂H HCO₂H salt, 108-9° (from EtOH-EtOAc), D, 0.8, 1.5, 490, 45; 4,3-Cl(O₂N)C₆H₃CO₂H, 185-7° (from EtOH), C, -, -, -, -; 4,3-Cl(H₂N)C₆H₃CO₂H, 179-80.5°, D, 0.3, 2.0, 570, 68. The amino alc. in the preparation of IV neutralized incompletely gave N-[2-(2-chloro-4-nitrobenzoxy)-1-propyl]-N-cyclohexyl-2-chloro-4-nitrobenzamide) cream-colored solid, m. 156.5-58° (from CHCl₃-Et₂O) as a by-product. 2,4-(O₂N)₂C₆H₃CO₂(CH₂)₂NEt₂ (0.6 g.) in 20 cc. EtOH and 1 cc. 3N NH₄OH treated at room temperature 0.5 hr. with H₂S, the mixture filtered, and the filtrate concentrated gave 0.2 g. 4,2-HONH(O₂N)C₆H₃CO₂(CH₂)₂NEt₂, m. 170-2° (from EtOH) having topical activity 0, intradermal activity 0.5, subcutaneous LD₅₀ 790, and intravenous LD₅₀ 55.

Journal of the American Chemical Society published new progress about 5204-46-6. 5204-46-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Amine,Benzene, name is 4-Amino-2,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Computed Properties of 5204-46-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

D’Onofrio, Jennifer published the artcileNovel cyclic phosphate-linked oligosaccharides (CyPLOSs) covalently immobilized on solid supports for potential cation scavenging, SDS of cas: 33697-81-3, the publication is European Journal of Organic Chemistry (2007), 3849-3858, database is CAplus.

For potential cation scavenging both from water and from organic solvents, a synthetic procedure for functionalization of a Tentagel solid support with novel cyclic phosphate-linked oligosaccharide (CyPLOS) analogs I (R = TBDMS, H) is described. To establish the feasibility of the synthetic strategy, the cyclic dimer was the model compound selected to be incorporated onto the solid support. This functionalization was achieved through a stepwise solid-phase synthesis of the linear dimer, obtained by standard phosphoramidite protocols, followed by a synthesis of the cyclic mol. on the resin. The key intermediate was a suitably derivatized sugar phosphoramidite building block II, with the secondary hydroxy functions masked as TBDMS ethers. This proved to be an orthogonal protection with respect to the DMT ether, fully compatible with the phosphoramidite and the phosphotriester chem. used for the oligomerization and the cyclization process onto the solid support, resp. Conditions for the total unmasking of the hydroxy groups of the cyclic dimer, not affecting the integrity of the cyclic structure nor its linkage with the solid matrix, have been optimized. Gel-phase ³¹P NMR spectroscopy has been used extensively here to monitor the efficiency of the reactions carried out on the solid support.

European Journal of Organic Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, SDS of cas: 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Di Fabio, Giovanni published the artcileA versatile synthetic approach for the development of libraries of 5′,3′-bis-conjugated oligonucleotides, Quality Control of 33697-81-3, the publication is Nucleic Acids Symposium Series (2008), 52(1), 299-300, database is CAplus and MEDLINE.

A symposium. A versatile approach to develop libraries of diverse 5′,3′-bis-conjugated oligonucleotides (ODNs) is here described. The usage of ad hoc derivatized solid supports, to which the first nucleoside unit is attached through a phosphate linkage, opens easy synthetic access to a large variety of hybrid bis-conjugated oligomers. The G-quadruplex forming d(^5′TGGGAG^3′) sequence, as a potential anti-HIV agent, has been here used as a model system.

Nucleic Acids Symposium Series published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Braguglia, C. M. published the artcileQuality assessment of digested sludges produced by advanced stabilization processes, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Environmental Science and Pollution Research (2015), 22(10), 7216-7235, database is CAplus and MEDLINE.

The European Union (EU) Project Routes aimed to discover new routes in sludge stabilization treatments leading to high-quality digested sludge, suitable for land application. In order to investigate the impact of different enhanced sludge stabilization processes such as (a) thermophilic digestion integrated with thermal hydrolysis pretreatment (TT), (b) sonication before mesophilic/thermophilic digestion (UMT), and (c) sequential anaerobic/aerobic digestion (AA) on digested sludge quality, a broad class of conventional and emerging organic micropollutants as well as ecotoxicity was analyzed, extending the assessment beyond the parameters typically considered (i.e., stability index and heavy metals). The stability index was improved by adding aerobic posttreatment or by operating dual-stage process but not by pretreatment integration. Filterability was worsened by thermophilic digestion, either alone (TT) or coupled with mesophilic digestion (UMT). The concentrations of heavy metals, present in ranking order Zn > Cu > Pb > Cr ∼ Ni > Cd > Hg, were always below the current legal requirements for use on land and were not removed during the processes. Removals of conventional and emerging organic pollutants were greatly enhanced by performing double-stage digestion (UMT and AA treatment) compared to a single-stage process as TT; the same trend was found as regards toxicity reduction Overall, all the digested sludges exhibited toxicity to the soil bacterium Arthrobacter globiformis at concentrations about factor 100 higher than the usual application rate of sludge to soil in Europe. For earthworms, a safety margin of factor 30 was generally achieved for all the digested samples.

Environmental Science and Pollution Research published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brady, P. Rex published the artcileEvaluation of some reactive disperse dyes for sublimation transfer printing of wool, SDS of cas: 18791-02-1, the publication is Journal of the Society of Dyers and Colourists (1981), 97(4), 159-65, database is CAplus.

The transfer printing of wool by the sublimation method was examined using 12 azo and 2 anthraquinone low-mol.-weight dyes containing 6 different types of reactive groups. To achieve build-up of the dyes to heavy depths, the wool was pretreated with a polymer, e.g. Primal K3 (I) [37331-35-4], or a surfactant and steamed after dye transfer. Only the yellow dyes exhibited good fastness properties on pure wool. On wool-polyester blend fabrics that had been treated with I, fastness values were generally intermediate between those for pure polyester fabrics and I-treated wool.

Journal of the Society of Dyers and Colourists published new progress about 18791-02-1. 18791-02-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 2,3-Dibromopropionylchloride, and the molecular formula is C3H3Br2ClO, SDS of cas: 18791-02-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Evans, Nicola published the artcileIn vitro activity of a panel of per- and polyfluoroalkyl substances (PFAS), fatty acids, and pharmaceuticals in peroxisome proliferator-activated receptor (PPAR) alpha, PPAR gamma, and estrogen receptor assays, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Toxicology and Applied Pharmacology (2022), 116136, database is CAplus and MEDLINE.

Data demonstrate numerous per- and polyfluoroalkyl substances (PFAS) activate peroxisome proliferator-activated receptor alpha (PPARα), however, addnl. work is needed to characterize PFAS activity on PPAR gamma (PPARγ) and other nuclear receptors. We utilized in vitro assays with either human or rat PPARα or PPARγ ligand binding domains to evaluate 16 PFAS (HFPO-DA, HFPO-DA-AS, NBP2, PFMOAA, PFHxA, PFOA, PFNA, PFDA, PFOS, PFBS, PFHxS, PFOSA, EtPFOSA, and 4:2, 6:2 and 8:2 FTOH), 3 endogenous fatty acids (oleic, linoleic, and octanoic), and 3 pharmaceuticals (WY14643, clofibrate, and the metabolite clofibric acid). We also tested chems. for human estrogen receptor (hER) transcriptional activation. Nearly all compounds activated both PPARα and PPARγ in both human and rat ligand binding domain assays, except for the FTOH compounds and PFOSA. Receptor activation and relative potencies were evaluated based on effect concentration 20% (EC20), top percent of max fold induction (pmaxtop), and area under the curve (AUC). HFPO-DA and HFPO-DA-AS were the most potent (lowest EC20, highest pmaxtop and AUC) of all PFAS in rat and human PPARα assays, being slightly less potent than oleic and linoleic acid, while NBP2 was the most potent in rat and human PPARγ assays. Only PFHxS, 8:2 and 6:2 FTOH exhibited hER agonism >20% pmax. In vitro measures of human and rat PPARαand PPARγ activity did not correlate with oral doses or serum concentrations of PFAS that induced increases in male rat liver weight from the National Toxicol. Program 28-d toxicity studies. Data indicate that both PPARα and PPARγ activation may be mol. initiating events that contribute to the in vivo effects observed for many PFAS.

Toxicology and Applied Pharmacology published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Recommanded Product: Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Huaisheng published the artcileDiscovery of a quinoline-based phenyl sulfone derivative as an antitrypanosomal agent, Application of 3-Chloro-4-hydroxyphenylacetic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(9), 1647-1651, database is CAplus and MEDLINE.

A series of natural products-based Ph sulfone derivative and their property-based analogs were investigated as potential growth inhibitors of Trypanosoma brucei. Trypanosoma brucei is a kinetoplastid protozoan parasite that causes trypanosomiasis. In this work, the authors found that nopol- and quinoline-based Ph sulfone derivative were the most active and selective for T. brucei, and they were not reactive towards the active thiol of T. brucei’s cysteine protease rhodesain. A thiol reactive variant of the quinoline-based Ph sulfone was subsequently investigated and found to be a moderate inhibitor of rhodesain. The quinoline-based compound that is not reactive towards rhodesain can serve a template for phenotypic-based lead discovery while its thiol-active congener can serve as template for structure-based investigation of new antitrypanosomal agents.

Bioorganic & Medicinal Chemistry Letters published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C24H12, Application of 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Grandin, Catherine published the artcileA practical synthesis of cycloalkylphosphonates from trichloromethylphosphonates, Application In Synthesis of 866-23-9, the publication is Synthesis (1995), 239-41, database is CAplus.

Cycloalkylophosphonates I (R = Et, CHMe₂, n = 1,2,3,4, X = H) with ring size varying from 4 to 6 were synthesized in good overall yields, in two steps from trichloromethylphosphonates and ω-dibromalkanes, via the corresponding α-trimethylsilyl cycloalkylphosphonates I (X = SiMe₃, R and n = same).

Synthesis published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics