Month: December 2022

Sanchez, Laura M. published the artcileVersatile Method for the Detection of Covalently Bound Substrates on Solid Supports by DART Mass Spectrometry, Recommanded Product: 2-Chlorotrityl chloride, the publication is Organic Letters (2011), 13(15), 3770-3773, database is CAplus and MEDLINE.

Anal. of substrates directly on solid phase resins without the need for sep. cleavage conditions remains an outstanding challenge in the field of solid phase synthesis. The authors now present the 1st example of simultaneous cleavage and mass spectrometric anal. of peptides from solid supports using direct anal. in real time (DART) mass spectrometry. This method is compatible with a diverse array of solid phase resins and is suitable for anal. of both peptides and organic substrates.

Organic Letters published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Recommanded Product: 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hu, Wen-bin published the artcileSynthesis of microporous silica supported ligand Pt catalyst for hydrosilylation of 1-octene, Category: chlorides-buliding-blocks, the publication is Xiandai Huagong (2007), 27(4), 27-29, database is CAplus.

A novel silica-supported platinum catalyst has been prepared by a simple one-step procedure, using a sol-gel method, and characterized. The solventless hydrosilylation reaction between 1-octene and methyldichlorosilane (I) in an autoclave reactor catalyzed by this catalyst was studied. The catalyst can bring a 99.11% conversion rate of I with 100% β-adduct in regioselectivity at 40°C after 10-h reaction. It has excellent catalyst recyclability relative to Speier’s catalyst under the reaction conditions, after 25 times of reuse the catalyst has no loss in catalytic activity.

Xiandai Huagong published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fu, Dong-Jun published the artcileDiscovery of novel indole derivatives that inhibit NEDDylation and MAPK pathways against gastric cancer MGC803 cells, SDS of cas: 620-20-2, the publication is Bioorganic Chemistry (2021), 104634, database is CAplus and MEDLINE.

A series of novel indole derivatives were synthesized and evaluated for their antiproliferative activity against three selected cancer cell lines (MGC803, EC-109 and PC-3). Among these analogs, 2-(5-methoxy-1H-indol-1-yl)-N-(4-methoxybenzyl)-N-(3,4,5-trimethoxyphenyl)acetamide (I) showed the best inhibitory activity against MGC803 cells with an IC₅₀ value of 1.59μM. Cellular mechanisms elucidated that I inhibited colony formation, induced apoptosis and arrested cell cycle at G2/M phase. Importantly, indole analog I inhibited NEDDylation pathway and MAPK pathway against MGC803 cells.

Bioorganic Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wu, Bowen published the artcileDesign, synthesis and anticancer activity studies of novel trimethoxyphenyl-quinoline derivatives, Recommanded Product: 3-Chlorobenzylchloride, the publication is Youji Huaxue (2020), 40(4), 978-987, database is CAplus.

A series of novel trimethoxyphenyl-quinoline hybrids I [R = 4-MeC₆H₄, 4-FC₆H₄, 5-Cl-2-thienyl, etc.] were designed, synthesized and evaluated for antiproliferative activity against three human cancer cell lines. Compound I [R = 3-ClCH₂C₆H₄] showed the most potent antitumor activity against PC-3 cells with IC₅₀ value of 9.23μmol/L. Meanwhile, compound I [R = 3-ClCH₂C₆H₄] inhibited the cell viability and colony formation of PC-3 cells. Further mechanism studies revealed that compound I [R = 3-ClCH₂C₆H₄] could arrest PC-3 cells in G2/M phase and induce cell apoptosis via activating intrinsic and extrinsic apoptosis pathway.

Youji Huaxue published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C15H23BO2, Recommanded Product: 3-Chlorobenzylchloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Xing, Siyang published the artcileDiastereoselective synthesis of cis-1,3-disubstituted isoindolines via a highly site-selective tandem cyclization reaction, Safety of Sodium chloro(tosyl)amide trihydrate, the publication is Organic Chemistry Frontiers (2018), 5(12), 1950-1956, database is CAplus.

A highly site-selective tandem reaction involving regioselective ring opening of aziridines and Michael addition of electron-deficient alkenes was described. O-atom nucleophiles, produced by the reaction of aldehydes and NHCs in open air, preferred to attack the less hindered aziridine carbons, followed by further intramol. aza-Michael addition to afford a series of cis-1,3-disubstituted isoindolines in good yields with good diastereoselectivities. High selectivities, high efficiency and mild conditions made this tandem reaction very suitable for the rapid construction of libraries of isoindoline compounds

Organic Chemistry Frontiers published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C10H17N3O2, Safety of Sodium chloro(tosyl)amide trihydrate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nuti, Elisa published the artcileSugar-Based Arylsulfonamide Carboxylates as Selective and Water-Soluble Matrix Metalloproteinase-12 Inhibitors, Application of (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, the publication is ChemMedChem (2016), 11(15), 1626-1637, database is CAplus and MEDLINE.

Matrix metalloproteinase-12 (MMP-12) can be considered an attractive target to study selective inhibitors useful in the development of new therapies for lung and cardiovascular diseases. .In this study, a new series of arylsulfonamide carboxylates, with increased hydrophilicity resulting from conjugation with a β-N-acetyl-D-glucosamine moiety, were designed and synthesized as MMP-12 selective inhibitors. Their inhibitory activity was evaluated on human MMPs by using the fluorimetric assay, and a crystallog. anal. was performed to characterize their binding mode. Among these glycoconjugates, a nanomolar MMP-12 inhibitor with improved water solubility, compound I was identified.

ChemMedChem published new progress about 870778-91-9. 870778-91-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid, and the molecular formula is C13H12BClO3, Application of (4-((4-Chlorobenzyl)oxy)phenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Passos, Helena published the artcileSelective Sequential Recovery of Zinc and Copper from Acid Mine Drainage, Computed Properties of 23616-79-7, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(10), 3647-3657, database is CAplus.

The observed imbalance between the unsustainable consumption of available natural metal resources and finite deposits makes the recovery and recycling of metals from metal-containing wastes an imperative. Here, ionic-liquid-based aqueous biphasic systems (IL-based ABSs) are proposed as an efficient alternative for selective metal recovery from real copper acid mine drainage (AMD) effluents. ABSs composed of different ILs and Na₂SO₄ were evaluated for Zn, Al, Cu, Co, and Ni extraction from both model solutions and AMD samples. It is shown that IL composed of thiocyanate anion ([SCN]^–) presented a remarkable ability to extract metals from AMD through the formation of stable metal complexes. The addition of NaSCN to ABSs composed of tetrabutylammonium chloride ([N₄₄₄₄]Cl) allowed to mimic the use of [SCN]-based IL with addnl. advantages: tunable metal selectivity by the concentration of [SCN]^– added to the ABS and a reduction in system cost and environmental impact. Furthermore, at the [SCN]^– concentration range studied here, the formation of a hydrophobic salt composed of IL cations and metal complex anions is observed, which allows the selective extraction and recovery of transition metals in a single step. The IL-rich phase recyclability in three extraction cycles is demonstrated, showing the possibility to recover two times more Zn than with a single extraction cycle while using the same amount of IL and thiocyanate. Salt-rich phases were also recycled in a new IL-based ABS for the subsequent Cu extraction and recovery. These results allow the development of a sustainable process for the selective sequential recovery of transition metals from AMD.

ACS Sustainable Chemistry & Engineering published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Computed Properties of 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Capuano, Ben published the artcileSynthesis and preliminary pharmacological evaluation of 4′-arylmethyl analogues of clozapine. I. The effect of aromatic substituents, Formula: C13H9ClN2O4, the publication is Australian Journal of Chemistry (2002), 55(9), 565-576, database is CAplus.

As part of a research program to develop compounds with mixed dopamine D₄ and serotonin 5-HT_2A antagonist activity with potential for the treatment of schizophrenia, the preparation of 8-chloro-11-[4-(phenylmethyl)-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives I (R = H, Br, Cl, F, Me, OMe, CF₃, OCF₃, etc.) based on a structural modification of the atypical antipsychotic clozapine was reported. Corresponding 8-chloro-11-[4-[(1H-indol-3-yl)methyl]-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives, bioisosteric 8-chloro-11-[4-[(pyridinyl)methyl]-1-piperazinyl]-5H-dibenzo[b,e][1,4]diazepine derivatives, 4-[[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-piperazinyl]methyl]-1,2-benzenediol and 3-[[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)-1-piperazinyl]methyl]-1H-indol-5-ol were also prepared The chem. synthesis, structural characterization and pharmacol. evaluation of a series 4′-arylmethyl analogs of clozapine are described. Preliminary receptor binding data are presented, examining primarily the electronic and positional effects of substituents on the introduced arylmethyl group, and secondarily the nature of the aryl ring.

Australian Journal of Chemistry published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C13H9ClN2O4, Formula: C13H9ClN2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Guirado, Gonzalo published the artcileElectrochemical Remote Control for Dithienylethene-Ferrocene Switches, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Journal of Physical Chemistry C (2007), 111(6), 2770-2776, database is CAplus.

The electrochromic properties of dithienylethene derivatives is a field of great importance and interest. In this manuscript the authors describe a potential mol. remote control system, which can be electrochem. triggered. Diferrocenyl compounds containing a diethylenene photoelectrochromic core with perhydro- and perfluorocyclopentene ring were prepared to induce a change in the chromic properties via an intramol. electron-transfer reaction from the redox group to the photochromic core. The electrochem. behavior of open and closed isomers was thoroughly studied using photochem., electrochem., and spectroelectrochem. techniques. The 1st redox couple was typically assigned to the ferrocene for the open isomer. However, for the closed isomer, an electrocatalytic ring-opening process was observed for the perhydrocyclopentene ring, while a slightly different electrochem. process was observed for the perfluorocyclopentene system. Mechanistic studies revealed that an internal charge transfer is necessary to destabilize the closed bridge. Once opened, the bridge’s cation radical is a strong oxidant, and the charge eventually gets localized on the ferrocene. The charges then migrate throughout the solution by self-exchange reactions. Hence, the redox status of the Fc units triggers the photochrom’s reactivity playing the role of antenna that can temporarily store a charge and facilitate the transformation. This way to perform the transformation, i.e., by electrochem. rather than photochem., presents the great advantage of being much more local and, thus, would permit the ultimate stage of miniaturization at the scale of just one ol.

Journal of Physical Chemistry C published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pierson, R. M. published the artcileBis-type modifiers in polymerization. I. Behavior of various disulfides in bulk styrene polymerization, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane, the publication is Journal of Polymer Science (1955), 221-46, database is CAplus.

Studies were made of the effectiveness in low-conversion bulk styrene polymerizations of the modifiers, bis(2-ethylhexyl) disulfide, dibenzyl disulfide, bis(chlorobenzyl) disulfide, bis[2-(2-pyridyl)ethyl] disulfide, bis(2-chloroethyl)disulfide, bis(2-hydroxyethyl)disulfide, dithiodiacetic acid, esters of bis(2-carboxyethyl)disulfide, bis(2-chloroacetoxyethyl) disulfide, diphenyl disulfide, di-ο-tolyl disulfide, bis(2,6-xylyl) disulfide, bis(2,3,5,6-tetramethylphenyl) disulfide, bis(4-carboxyphenyl) disulfide, bis(4-carbethoxyphenyl) disulfide, bis(4-hydroxymethylphenyl)disulfide, bis(2-chloromethylphenyl) disulfide, bis(2-bromomethylphenyl)disulfide, bis(2-aminophenyl) disulfide, di-2-naphthyl disulfide, di-2-benzothiazolyl disulfide, bis(isopropylxanthogen) disulfide, 4,4′-dithiodimorpholine disulfide, carbonylbis(thioglycolic acid), thiocarbonylbis(thioglycolic acid), and tetraphenylhydrazine. Alkyl disulfides, even when substituted at C’s near the SS bond, had very low transfer constants The transfer constants of aryl disulfides were much higher and could be increased by substitutions, thereby incorporating desired groups into the polymer. They cleave to give one half the mol. to each end of the polymer as was shown by comparing end-group concentrations of styrene polymers containing various types of end groups with polymers modified by thiols containing similar groups.

Journal of Polymer Science published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Recommanded Product: 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics