Month: December 2022

Sharma, Praveen Kumar published the artcileSynthesis and antimicrobial activities of substituted phenylthioureas, Recommanded Product: 1-(4-Chlorophenyl)thiourea, the publication is Journal of Chemical and Pharmaceutical Research (2015), 7(2), 133-139, database is CAplus.

The synthesis of substituted phenylthioureas is reported. All the synthesized compounds were screened for their antimicrobial activities. These compounds were found to have antimicrobial activities comparable to and in some cases greater than those of equimolar quantities of standard drug.

Journal of Chemical and Pharmaceutical Research published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C9H4F6O, Recommanded Product: 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cui, Y. published the artcileSynthesis of novel oxazolidinone derivatives for antibacterial investigation, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, the publication is Current Science (2005), 89(3), 531-534, database is CAplus.

A series of oxazolidinones were synthesized and evaluated as antibacterial agents. They were screened in vitro against a panel of Gram-pos. organisms. Compound I was found to exhibit activity comparable to linezolid.

Current Science published new progress about 3919-74-2. 3919-74-2 belongs to chlorides-buliding-blocks, auxiliary class Isoxazole,Fluoride,Chloride,Carboxylic acid,Benzene, name is 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid, and the molecular formula is C11H7ClFNO3, Application of 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lenstra, Danny C. published the artcileStructure-Activity Relationship Studies on (R)-PFI-2 Analogues as Inhibitors of Histone Lysine Methyltransferase SETD7, Synthetic Route of 61551-49-3, the publication is ChemMedChem (2018), 13(14), 1405-1413, database is CAplus and MEDLINE.

SETD7 is a histone H3K4 lysine methyltransferase involved in human gene regulation. Aberrant expression of SETD7 has been associated with various diseases, including cancer. Therefore, SETD7 is considered a good target for the development of new epigenetic drugs. To date, few selective small-mol. inhibitors have been reported that target SETD7, the most potent being (R)-PFI-2. Herein we report structure-activity relationship studies on (R)-PFI-2 and its analogs. A library of 29 structural analogs of (R)-PFI-2 was synthesized and evaluated for inhibition of recombinantly expressed human SETD7. The key interactions were found to be a salt bridge and a hydrogen bond formed between (R)-PFI-2’s NH₂⁺ group and SETD7’s Asp256 and His252 residue, resp.

ChemMedChem published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Synthetic Route of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Le Manach, Claire published the artcileIdentification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts, Quality Control of 33697-81-3, the publication is Journal of Medicinal Chemistry (2021), 64(4), 2291-2309, database is CAplus and MEDLINE.

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp³-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chem. optimization and biol. profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (<50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogs followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance.

Journal of Medicinal Chemistry published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Quality Control of 33697-81-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Utkin, Ilya published the artcileSpecificity of reductive dehalogenation of substituted ortho-chlorophenols by Desulfitobacterium dehalogenans JW/IU-DC1, Category: chlorides-buliding-blocks, the publication is Applied and Environmental Microbiology (1995), 61(1), 346-51, database is CAplus and MEDLINE.

Resting cells of D. dehalogenans JW/IU-DC1 grown with pyruvate and 3-chloro-4-hydroxyphenylacetate (3-Cl-4-OHPA) as the electron acceptor and inducer of dehalogenation reductively ortho-dehalogenate pentachlorophenol (PCP), tetrachlorophenols (TeCPs), the trichlorophenols 2,3,4-TCP, 2,3,6-TCP, and 2,4,6-TCP, the dichlorophenols 2,3-DCP, 2,4-DCP, and 2,6-DCP, 2,6-dichloro-4-R-phenols, where R is -H, -F, -Cl, -NO₂, -CO₂^–, or -COOCH₃, 2-chloro-4-R-phenols (2-Cl-4-RPs, where R is -H, -F, -Cl, -Br, -NO₂, -CO₂^–, -CH₂CO₂^–, or -COOCH₃), and bromophenols (2-BrP, 2,6-DBrP, and 2-Br-4ClP). Monochlorophenols, the dichlorophenols 2,5-DCP, 3,4-DCP, and 3,5-DCP, the trichlorophenols 2,3,5-TCP, 2,4,5-TCP, and 3,4,5-TCP, and the fluorinated analog of 3-Cl-4-OHPA, 3-F-4-OHPA, are not dehalogenated. A Cl substituent in position 3 (meta), 4 (para), or 6 (2nd ortho) of the phenolic moiety facilitates ortho dehalogenation in position 2. Cl in the 5 (2nd meta) position has a neg. effect on the dehalogenation rate or even prevents dechlorination in the 2 position. In general, 2,6-DCl-4-RPs are dechlorinated faster than the corresponding 2-Cl-4-RPs with the same substituent R in the 4 position. The highest dechlorination rate, however, was found for dechlorination of 2,3-DCP, with a maximum observed 1st-order rate constant of 19.4/h-g (dry weight) biomass. There is no strong linear correlation between the logarithm of pseudo-1st-order rate constants for the dehalogenation of 2,6-DCl-4-RPs and 2-Cl-4-RPs and electronic (Hammett σ_m), hydrophobic (π), and stearic (E_s) constants of the substituent R. The substrate specificity and induction pattern found for dehalogenation with the pure culture of D. dehalogenans and the original 2,4-DCP-enrichment, derived from a methanogenic sediment, were similar, suggesting that the conditions used led to only 1 type of dechlorinating organism.

Applied and Environmental Microbiology published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H6KNO4S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boersma, Brenda J. published the artcileNeutrophil myeloperoxidase chlorinates and nitrates soy isoflavones and enhances their antioxidant properties, Product Details of C8H7ClO3, the publication is Free Radical Biology & Medicine (2003), 35(11), 1417-1430, database is CAplus and MEDLINE.

Soy isoflavones and other polyphenolics have a number of potentially important beneficial effects on the pro-oxidant aspects of chronic inflammation. The impact of inflammatory cell-specific metabolism of polyphenolics, which can include halogenation and nitration, on the properties of these compounds has not been examined Using either human neutrophils or differentiated human leukemia cells (HL-60) stimulated with phorbol ester to elicit a respiratory burst, the hypothesis that local generation of reactive oxygen and nitrogen species may metabolize and modify the biol. properties of the soy isoflavones was examined Coincubation of the stimulated cells with genistein or daidzein had no effect on the respiratory burst. Medium from stimulated cells in the presence of the isoflavones and NO₂^– increased the inhibition of copper-induced LDL oxidation Mass spectrometry anal. of this medium revealed that monochlorinated, dichlorinated, and nitrated isoflavones, formed through a myeloperoxidase-dependent mechanism, were present. The consumption of genistein in the presence of cells was both extensive and rapid with > 95% of the genistein converted to either the chlorinated or nitrated metabolites within 30 min. Chem. synthesized 3′-chlorogenistein and 3′-chlorodaidzein increased the inhibition of LDL oxidation by approx. 4-fold and 2-fold over genistein and daidzein, resp. These results lead to the hypothesis that inflammatory cell-specific metabolism of polyphenolics can modify the properties of these compounds at the local site of inflammation.

Free Radical Biology & Medicine published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Product Details of C8H7ClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileA Photoswitchable Triple Chemosensor for Cyanide Anion Based on Dicyanovinyl-Functionalized Dithienylethene, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is European Journal of Organic Chemistry (2019), 2019(22), 3614-3621, database is CAplus.

The development of new sensors for the accurate detection of cyanide anion has attracted more and more attention due to their potential applications in environmental and biol. systems. Here, two novel near-IR (NIR) photochromic compounds 1a and 1b, which were modified by the dicyanovinyl fragment with cyanide recognition function, were developed. Surprisingly, 1a presented an unprecedented triple sensing performance for cyanide anion (colorimetric-fluorescent-colorimetric), which can be used as a potential precision sensor for CN^– in environmental and biol. systems. Although 1b did not show triple detection behavior for CN^–, it could recognize CN^– and F^– synchronously and selectively by naked eyes. Also, their NIR photochromic behaviors could be modulated by the cyanide anion. Their sensing mechanism for CN^– or F^– was confirmed by absorption spectral studies, NMR titration, and DFT calculations

European Journal of Organic Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Recommanded Product: 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Zhao-Yang published the artcileStructure Switching and Modulation of the Magnetic Properties in Diarylethene-Bridged Metallosupramolecular Compounds by Controlled Coordination-Driven Self-Assembly, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, the publication is Angewandte Chemie, International Edition (2019), 58(13), 4339-4344, database is CAplus and MEDLINE.

The authors report three self-assembled iron complexes that comprised an anti-parallel open form (o-L-anti), a parallel open form (o-L-syn), and a closed form (c-L) of diarylethene conformers. Under kinetic control, Fe^II₂(o-L-anti)₃ was isolated, which exhibited a dinuclear structure with diamagnetic properties. Under light-irradiation control, Fe^II₂(c-L)₃ was prepared and exhibited paramagnetism and spin-crossover behavior. Under thermodn. control and in the presence of indispensable [Fe^III(Tp^*)(CN)₃]^–, Fe^II₂(o-L-anti)₃ and Fe^II₂(c-L)₃ transformed into tetranuclear Fe^III₂Fe^II₂(o-L-syn)₂, which exhibited complete spin-crossover behavior at T_1/2 = 353 K.

Angewandte Chemie, International Edition published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Application of 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Janczewski, Marian published the artcileEffect of molecular structure on the optical properties of sulfoxide systems. XLII. β-(1,2,3,4-Tetrahydro-6-naphthylsulfinyl)propionic acids and some their derivatives, Synthetic Route of 61551-49-3, the publication is Annales Universitatis Mariae Curie-Sklodowska, Sectio AA: Physica et Chemia (1977), 179-98, database is CAplus.

(±)-I[R = S(O)CH₂CH₂CO₂H] [(±)-II] was prepared and resolved as the cinchonine and cinchonidine salts. The dependence of the mol. rotation of (+)-II on the wavelength obeyed a single term Drude equation which indicated that the ORD exhibited a normal dispersion. The ORD and CD of (+)-II and (+)-III exhibited a pos. Cotton effects and mol. ellipticity which indicated that (+)-II and (+)-III had the same absolute configuration. The solvent effect on the optical rotation of (+)-II and the UV of II, III, and I(R = SO₂CH₂CH₂CO₂H) were discussed.

Annales Universitatis Mariae Curie-Sklodowska, Sectio AA: Physica et Chemia published new progress about 61551-49-3. 61551-49-3 belongs to chlorides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 5,6,7,8-Tetrahydronaphthalene-2-sulfonyl chloride, and the molecular formula is C10H11ClO2S, Synthetic Route of 61551-49-3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

He, Xiaohui published the artcileIdentification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases, Recommanded Product: 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, the publication is ACS Medicinal Chemistry Letters (2017), 8(10), 1048-1053, database is CAplus and MEDLINE.

NOD2 (nucleotide-binding oligomerization domain-containing protein 2) is an internal pattern recognition receptor that recognizes bacterial peptidoglycan and stimulates host immune responses. Dysfunction of NOD2 pathway has been associated with a number of autoinflammatory disorders. To date, direct inhibitors of NOD2 have not been described due to tech. challenges of targeting the oligomeric protein complex. Receptor interacting protein kinase 2 (RIPK2) is an intracellular serine/threonine/tyrosine kinase, a key signaling partner, and an obligate kinase for NOD2. As such, RIPK2 represents an attractive target to probe the pathol. roles of NOD2 pathway. To search for selective RIPK2 inhibitors, the authors employed virtual library screening (VLS) and structure based design that eventually led to a potent and selective RIPK2 inhibitor 8 (4-(7-ethoxy-6-(isopropylsulfonyl)imidazo[1,2-a]pyridin-3-yl)-6-fluoropyridin-2-amine) with excellent oral bioavailability, which was used to evaluate the effects of inhibition of RIPK2 in various in vitro assays and ex vivo and in vivo pharmacodynamic models.

ACS Medicinal Chemistry Letters published new progress about 960388-56-1. 960388-56-1 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronate Esters,Boronic Acids,Boronic acid and ester,Boronate Esters, name is 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, and the molecular formula is C12H16BClO3, Recommanded Product: 3-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics