Month: December 2022

Lanzi, Matteo published the artcileCyclic Diaryl λ³-Bromanes as Original Aryne Precursors, SDS of cas: 1451393-45-5, the publication is Angewandte Chemie, International Edition (2021), 60(27), 14852-14857, database is CAplus and MEDLINE.

Despite the widespread application of hypervalent iodines, the corresponding λ³-bromanes are less explored. Herein the authors report a general, safe, and high-yielding strategy to access cyclic diaryl λ³-bromanes. These unique compounds feature reactivity that is appealing and complementary to that of λ³-iodanes, generating arynes under mild reaction conditions and in the presence of a weak base. Accordingly, formal meta-selective transition-metal-free C-O and C-N couplings may be achieved. Mechanistic studies unambiguously support the aryne generation mechanism.

Angewandte Chemie, International Edition published new progress about 1451393-45-5. 1451393-45-5 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is (2-Bromo-4-chlorophenyl)boronic acid, and the molecular formula is C6H5BBrClO2, SDS of cas: 1451393-45-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lanzi, Matteo published the artcileCyclic Diaryl λ³-Bromanes as Original Aryne Precursors, HPLC of Formula: 1217501-18-2, the publication is Angewandte Chemie, International Edition (2021), 60(27), 14852-14857, database is CAplus and MEDLINE.

Despite the widespread application of hypervalent iodines, the corresponding λ³-bromanes are less explored. Herein the authors report a general, safe, and high-yielding strategy to access cyclic diaryl λ³-bromanes. These unique compounds feature reactivity that is appealing and complementary to that of λ³-iodanes, generating arynes under mild reaction conditions and in the presence of a weak base. Accordingly, formal meta-selective transition-metal-free C-O and C-N couplings may be achieved. Mechanistic studies unambiguously support the aryne generation mechanism.

Angewandte Chemie, International Edition published new progress about 1217501-18-2. 1217501-18-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Boronic acid and ester,Benzene,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (2-Bromo-5-chlorophenyl)boronic acid, and the molecular formula is C6H5BBrClO2, HPLC of Formula: 1217501-18-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shimpi, Nitin A. published the artcileNovel synthetic methodology for the synthesis of dibenzo azepines, Recommanded Product: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, the publication is Journal of Chemical and Pharmaceutical Research (2016), 8(4), 318-326, database is CAplus.

New synthetic methodol. for the synthesis of dibenzo[b,e][1,4]diazepines, a key intermediates in the manufacturing of Clozapine which is indicated for use in therapy as dopamine receptor antagonist, Antipsychotic drug. Synthesis of 2-(4-chloro-2-nitrophenylamino) benzoic acid Me ester by simple rearrangement of 2-[[2-(4-chloro-2-nitrophenoxy)acetyl]amino]benzoic acid Me ester. The present work describes a novel, cost-effective and easily scalable process of dibenzo[b,e][1,4]diazepines.

Journal of Chemical and Pharmaceutical Research published new progress about 60091-87-4. 60091-87-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitro Compound,Carboxylic acid,Amine,Benzene, name is 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid, and the molecular formula is C12H15ClO3, Recommanded Product: 2-((4-Chloro-2-nitrophenyl)amino)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Raju, D. Nooka published the artcileSynthesis, characterization and analgesic activity of some novel substituted 2-amino benzothiazole derivatives, Formula: C7H7ClN2S, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2015), 4(5), 1815-1821, database is CAplus.

The synthesis of some novel substituted 2-amino benzothiazoles I (R = 6-Cl, 6-Br, 6-NO₂, 6-COOH) is described. The synthesized compounds were screened for analgesic activity. Compounds I (R = 6-Cl, 6-NO₂) have highly significant analgesic activity with reference to the standard aspirin and consequently further exploration of these benzothiazole derivatives should make these mols. accessible for widespread use as potent analgesic agents.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Formula: C7H7ClN2S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tue Bi, Balo published the artcileElectrochemical preparation of diethyl chloromethyl- and dichloromethylphosphonates, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Tetrahedron Letters (1987), 28(33), 3799-800, database is CAplus.

Electrochem. reduction of (EtO)₂P(O)CCl₃ in alc. acetate solutions at a graphite electrode under galvanostatic conditions gave (EtO)₂P(O)CHCl₂ and (EtO)₂P(O)CH₂Cl in 80% isolated yields.

Tetrahedron Letters published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C8H17Br, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nagarajan, Srinivasan R. published the artcileR-Isomers of Arg-Gly-Asp (RGD) mimics as potent α_vβ₃ inhibitors, SDS of cas: 19652-33-6, the publication is Bioorganic & Medicinal Chemistry (2007), 15(11), 3783-3800, database is CAplus and MEDLINE.

The integrin α_vβ₃, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. The authors recently disclosed the discovery of a tripeptide Arg-Gly-Asp (RGD) mimic, which has been shown to be a potent inhibitor of the integrin α_vβ₃ and has excellent anti-angiogenic properties including its suppression of tumor growth in animal models. In other investigations involving RGD mimics, only compounds containing the S-isomers of the β-amino acids have been shown to be potent. The authors were surprised to find the potencies of analogs containing enantiomerically pure S-isomers of β-amino acids which were only marginally better than the corresponding racemic mixtures Thus, the authors synthesized RGD mimics containing R-isomers of β-amino acids and found them to be relatively potent inhibitors of α_vβ₃. One of the compounds, peptidomimetic I, was examined in tumor models in mice and has been shown to significantly reduce the rate of growth and the size of tumors.

Bioorganic & Medicinal Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, SDS of cas: 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lindemann, Marcel published the artcileDo spiroindolines have the potential to replace vesamicol as lead compound for the development of radioligands targeting the vesicular acetylcholine transporter?, Computed Properties of 6313-54-8, the publication is Bioorganic & Medicinal Chemistry (2017), 25(19), 5107-5113, database is CAplus and MEDLINE.

The vesicular acetylcholine transporter (VAChT) is an important target for in vivo imaging of neurodegenerative processes using positron emission tomog. (PET). So far the development of VAChT PET radioligands is based on the single known lead compound vesamicol. In this study we investigated a recently published spiroindoline based compound class (Sluder et al., 2012), which was suggested to have potential in the development of VAChT ligands. Therefore, we synthesized a small series of N,N-substituted spiro[indoline-3,4′-piperidine] derivatives and determined their in vitro binding affinities toward the VAChT. In order to investigate the selectivity, the off-target binding toward σ₁ and σ₂ receptors was determined The compounds possessed VAChT affinities with K_i values in the range of 39-376 nM. Binding affinities toward the σ₁ and σ₂ receptors are in a similar range indicating that the strong structural difference between the spiroindolines and vesamicol did not improve the selectivity. The observed potential to addnl. bind to σ receptors let us assume that the herein investigated spiroindolines are not suitable to replace vesamicol as lead compound for the development of VAChT ligands.

Bioorganic & Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Computed Properties of 6313-54-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zade, Varsha S. published the artcileSynthesis and biological evaluation of S-maltosylated 1,2,4-thiadiazoline derivatives against human pathogens, Safety of 1-(4-Chlorophenyl)thiourea, the publication is Indian Journal of Heterocyclic Chemistry (2014), 24(2), 163-166, database is CAplus.

A series of new 4-aryl-5-p-tolylimino-3-S-hepta-O-acetyl maltosyl-1,2,4-thiadiazolines, e.g. I, were synthesized by the interaction of N-p-tolyl-S-chloro isothiocarbamoyl chloride with S-hepta-O-acetyl maltosyl-1-aryl isothiocarbamides. These compounds were screened for their antibacterial and antifungal activities against E. coli, S. aureus, P. aerUginosa, S. typhi, R. oligospora and A. niger. The identities of these newly synthesized thiomaltosides have been established on the basis of chem. transformations and IR, 1H NMR and mass spectral studies. These compounds show most significant activity towards these micro-organisms.

Indian Journal of Heterocyclic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H4BrClO2, Safety of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zade, Varsha S. published the artcileSynthesis and characterization of per-acetylated S-maltosyl 2-isothiobiurets and 2,4-isodithiobiurets and their in vitro antimicrobial activity, Synthetic Route of 3696-23-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2015), 54B(6), 815-820, database is CAplus.

A series of S-hepta-O-acetyl-maltosyl-1-aryl-5-p-tolyl-2-isothio-biurets, S-hepta-O-acetyl-maltosyl-1-aryl-5-p-chloro-phenyl-2-isothio-biurets and S-hepta-O-acetyl maltosyl-1-aryl-5-p-tolyl-2,4-isodithio-biurets have been synthesized by the interaction of various S-hepta-O-acetyl maltosyl-1-aryl isothiocarbamides with p-tolyl isocyanate, p-chloro-Ph isocyanate and p-tolyl isothiocyanate resp. The required maltosyl arylisothiocarbamides are synthesized by the displacement of anomeric bromide of acetobromomaltose with aryl thiocarbamides. The identities of these newly synthesized thiomaltosides have been established on the basis of chem. transformations and IR, mass, 1H and 13C NMR spectral studies. These compounds have been screened for their antibacterial and antifungal activities against E. coli, S. aureus, Ps. aeruginosa, S. typhi, R. oligosporus and A. niger. These compounds show most promising activity towards these micro-organisms.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H4BrClO2, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Karhe, Usha W. published the artcileSynthesis of some biologically important per-O-benzoyl maltosyl isothiocarbamides and isodithiobiurets as antibacterial and antifungal agents, Computed Properties of 3696-23-9, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (2014), 53B(2), 212-217, database is CAplus.

Several S-hepta-O-benzoyl maltosyl-1-arylisothiocarbamides have been synthesized through several steps viz. benzoylation, bromination and interaction of hepta-O-benzoyl maltosyl bromide with aryl thiocarbamides. S-Hepta-O-benzoyl maltosyl-1-aryl-5-phenyl-2,4-isodithiobiurets have been synthesized by the interaction of S-hepta-O-benzoyl maltosyl-1-arylisothiocarbamides with Ph isothiocyanate. All new compounds have been characterized by spectral anal. such as IR, ¹H NMR and mass spectra as well as elemental anal. and in-vitro antimicrobial activity of maltosyl isothiocarbamides and related isodithiobiurets has been evaluated against several human pathogens. Out of 12 compounds prepared and screened, four compounds have shown significant activity against different human pathogens.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Computed Properties of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics