Month: December 2022

Shen, Hong C. published the artcileDiscovery of Biaryl Anthranilides as Full Agonists for the High Affinity Niacin Receptor, Product Details of C6H6BClO3, the publication is Journal of Medicinal Chemistry (2007), 50(25), 6303-6306, database is CAplus and MEDLINE.

Biaryl anthranilides are reported as potent and selective full agonists for the high affinity niacin receptor GPR109A. The SAR presented outlines approaches to reduce serum shift and both CYPCYP2C8 and CYP2C9 liabilities, while improving PK and maintaining excellent receptor activity. Compound 2i (I) exhibited good in vivo antilipolytic efficacy while providing a significantly improved therapeutic index over vasodilation (flushing) with respect to niacin in the mouse model.

Journal of Medicinal Chemistry published new progress about 766549-26-2. 766549-26-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronic Acids,Boronic acid and ester, name is 2-Chloro-4-hydroxyphenylboronic acid, and the molecular formula is C8H10O2, Product Details of C6H6BClO3.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Hamann, Lawrence G. published the artcileBenzodiazepine-based selective inhibitors of mitochondrial F₁F₀ ATP hydrolase, Recommanded Product: 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, the publication is Bioorganic & Medicinal Chemistry Letters (2004), 14(4), 1031-1034, database is CAplus and MEDLINE.

A series of benzodiazepine-based inhibitors of mitochondrial F₁F₀ ATP hydrolase were prepared and evaluated for their ability to selectively inhibit the enzyme in the forward direction. Compounds from this series showed excellent potency and selectivity for ATP hydrolase vs. ATP synthase, suggesting a potentially beneficial profile useful for the treatment of ischemic heart disease. The most potent member of the group of compounds thus tested was 4-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-2-(2-phenylethyl)-1H-1,4-benzodiazepine (I). I also inhibited cytochrome P 450 isoform CYP2C9. The structure of I was further modified to diminish this undesired side effect.

Bioorganic & Medicinal Chemistry Letters published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Recommanded Product: 2-Chloro-4-cyanobenzene-1-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cockcroft, Xiao-ling published the artcilePhthalazinones 2: Optimisation and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase, Synthetic Route of 116853-97-5, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(4), 1040-1044, database is CAplus and MEDLINE.

We have previously described the discovery of poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors based on a phthalazinone scaffold. Subsequent optimization of inhibitory activity, metabolic stability and pharmacokinetic parameters has led to a novel series of meta-substituted 4-benzyl-2H-phthalazin-1-one PARP-1 inhibitors which retain low nM cellular activity and show good stability in vivo and efficacy in cell based models.

Bioorganic & Medicinal Chemistry Letters published new progress about 116853-97-5. 116853-97-5 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,acyl chloride,Ether, name is 2-Chloro-6-methoxyisonicotinoyl chloride, and the molecular formula is C7H5Cl2NO2, Synthetic Route of 116853-97-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Broekhuysen, J. published the artcileAnalytical separation of various betaines and quaternary ammonium derivatives by paper electrorheophoresis, COA of Formula: C7H16ClNO2, the publication is Annales de Biologie Clinique (1961), 533-47, database is CAplus and MEDLINE.

Data are given on the electrophoretic behavior on paper of the betaine from crotonic acid and Me₃N, glycine betaine, γ-butyrobetaine, carnitine, choline, creatine, creatinine, Et ester of carnitine, β-homocholine, neurine, phosphocholine, phosphoethanolamine, tetramethylammonium ion, and Me₃N⁺. The elec. mobility was demonstrated to be a simple function of the specific charge on the ion, a relation which holds also for closely related compounds such as creatine and creatinine which were separated sharply by electrorheophoresis. The specific charges differed greatly at different pH values. It was possible, when dissociation constants were known, to determine the pH for optimum separation of the different compounds The advantage of electrorheophoresis is that the rate of migration may be modified by changing the ionic force of the buffer used without altering the pH. The method is applicable to the separation of substances of biol. origin from attendant impurities.

Annales de Biologie Clinique published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Stanford, Stephanie M. published the artcileDiscovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase, SDS of cas: 620-20-2, the publication is Journal of Medicinal Chemistry (2021), 64(9), 5645-5653, database is CAplus and MEDLINE.

Obesity-associated insulin resistance plays a central role in the pathogenesis of type 2 diabetes. A promising approach to decrease insulin resistance in obesity is to inhibit the protein tyrosine phosphatases that neg. regulate insulin receptor signaling. The low-mol.-weight protein tyrosine phosphatase (LMPTP) acts as a critical promoter of insulin resistance in obesity by inhibiting phosphorylation of the liver insulin receptor activation motif. Here, we report development of a novel purine-based chem. series of LMPTP inhibitors. These compounds inhibit LMPTP with an uncompetitive mechanism and are highly selective for LMPTP over other protein tyrosine phosphatases. We also report the generation of a highly orally bioavailable purine-based analog that reverses obesity-induced diabetes in mice.

Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C12H14O2, SDS of cas: 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Chen, Yen-Wei published the artcilePharmOmics: A species- and tissue-specific drug signature database and gene-network-based drug repositioning tool, SDS of cas: 637-07-0, the publication is iScience (2022), 25(4), 104052, database is CAplus and MEDLINE.

Drug development has been hampered by a high failure rate in clin. trials due to our incomplete understanding of drug functions across organs and species. Therefore, elucidating species- and tissue-specific drug functions can provide insights into therapeutic efficacy, potential adverse effects, and interspecies differences necessary for effective translational medicine. Here, we present PharmOmics, a drug knowledgebase and anal. tool that is hosted on an interactive web server. Using tissue- and species-specific transcriptome data from human, mouse, and rat curated from different databases, we implemented a gene-network-based approach for drug repositioning. We demonstrate the potential of PharmOmics to retrieve known therapeutic drugs and identify drugs with tissue toxicity using in silico performance assessment. We further validated predicted drugs for nonalcoholic fatty liver disease in mice. By combining tissue- and species-specific in vivo drug signatures with gene networks, PharmOmics serves as a complementary tool to support drug characterization and network-based medicine.

iScience published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, SDS of cas: 637-07-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Toader, Gabriela published the artcileEco-Friendly Peelable Active Nanocomposite Films Designed for Biological and Chemical Warfare Agents Decontamination, Safety of 1,2-Bis(2-chloroethyl)disulfane, the publication is Polymers (Basel, Switzerland) (2021), 13(22), 3999, database is CAplus and MEDLINE.

In the context of imminent threats concerning biol. and chem. warfare agents, the aim of this study was the development of a new method for biol. and chem. decontamination, employing non-toxic, film-forming, water-based biodegradable solutions, using a nano sized reagent together with bentonite as trapping agents for the biol. and chem. contaminants. Bentonite-supported nanoparticles of Cu, TiO₂, and Ag were successfully synthesized and dispersed in a polyvinyl alc. (PVA)/glycerol (GLY) aqueous solution The decontamination effectiveness of the proposed solutions was evaluated by qual. and quant. anal. techniques on various micro-organisms, with sulfur mustard (HD) and di-Me methylphosphonate (DMMP) as contaminants. The results indicate that the peelable active nanocomposite films can be successfully used on contaminated surfaces to neutralize and entrap the hazardous materials and their degradation products. Mech. and thermal characterization of the polymeric films was also performed to validate the decontamination solution′s potential as peelable-film generating materials. The removal efficacy from the contaminated surfaces for the tested micro-organisms varied between 93% and 97%, while for the chem. agent HD, the highest decontamination factor obtained was 90.89%. DMMP was almost completely removed from the contaminated surfaces, and a decontamination factor of 99.97% was obtained.

Polymers (Basel, Switzerland) published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C12H10FeO4, Safety of 1,2-Bis(2-chloroethyl)disulfane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fanfoni, Lidia published the artcileEfficient synthesis of new fluorinated building blocks by means of hydroformylation, Quality Control of 864725-22-4, the publication is Chimia (2014), 68(6), 371-377, database is CAplus and MEDLINE.

The hydroformylation reactions of fluorinated olefins were reviewed and added new results from the research group. The particular attention is paid to the remarkable influence of organofluorine substituents on catalyst activity, regio- and stereoselectivity of the hydroformylation reaction.

Chimia published new progress about 864725-22-4. 864725-22-4 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Alkenyl,Benzene, name is 1,3-Dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene, and the molecular formula is C9H5Cl2F3, Quality Control of 864725-22-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Crotti, Simone published the artcileEnantioselective Synthesis of Trifluoromethyl α,β-Unsaturated δ-Lactones via Vinylogous Aldol-Lactonization Cascade, Name: 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, the publication is Journal of Organic Chemistry (2018), 83(20), 12440-12448, database is CAplus and MEDLINE.

The novel vinylogous aldol-lactonization cascade of alkylidene oxindole with trifluoromethyl ketones is presented. The reaction, catalyzed by a bifunctional tertiary amine, provides an efficient application of the vinylogous reactivity of alkylidene oxindoles for the preparation of enantioenriched trifluoromethylated α,β-unsaturated δ-lactones.

Journal of Organic Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Name: 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

De Napoli, Lorenzo published the artcileAn efficient solid phase synthesis of 5′-phosphodiester and phosphoramidate monoester nucleoside analogs, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid, the publication is Chemical Communications (Cambridge, United Kingdom) (2005), 2586-2588, database is CAplus and MEDLINE.

An easy and efficient strategy to obtain libraries of 5′-phosphodiester and 5′-phosphoramidate monoester nucleoside analogs in a highly pure form has been developed, starting from a new nucleoside based solid support. The nucleoside scaffold has been anchored through a 5′-phosphodiester linkage to Tentagel HL resin, functionalized with a 3-chloro-4-hydroxyphenylacetic linker. The solid phase synthesis of small libraries of 5′-phosphodiester and 5′-phosphoramidate monoester thymidine analogs is also reported.

Chemical Communications (Cambridge, United Kingdom) published new progress about 33697-81-3. 33697-81-3 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Phenol, name is 3-Chloro-4-hydroxyphenylacetic acid, and the molecular formula is C8H7ClO3, Recommanded Product: 3-Chloro-4-hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics