Month: December 2022

Drake, R. published the artcileOptimization of polystyrene resin-supported Pt catalysts in room temperature, solvent-less, 1-octene hydrosilylation using methyldichlorosilane, Category: chlorides-buliding-blocks, the publication is Combinatorial Chemistry and High Throughput Screening (2002), 5(3), 201-209, database is CAplus and MEDLINE.

Six precursor resins with systematic variation of porous parameters were prepared by suspension polymerization using specific compositions of divinylbenzene, styrene vinylbenzyl chloride (VBC) and 2-ethylhexan-1-ol (a porogen) and the surface areas from N₂ sorption and BET anal. were ∼2-170 m²·g^-1. The VBC content in each case was 38 mol% and these groups were aminated using the sodium salt of trimethylethylenediamine and Pt was introduced onto each resin at three different loadings (∼0.03, ∼ 0.2 and ∼ 0.4 mmol·g^-1) by appropriate manipulation of K₂PtCl₄. The matrix of 18 resin-supported Pt complexes was then assessed for catalytic activity in the room temperature, solvent-less, hydrosilylation of 1-octene using methyldichlorosilane such that alkene:silane:Pt ratio was fixed as 2:1:1×10^-3. Though all the catalysts showed activity lower than that of homogeneous Speier’s catalyst, most were sufficiently active to be potentially valuable heterogeneous catalysts in the laboratory, and indeed the plant. The most lightly loaded resins proved to be the least active and the remainders were recycled 5 times, and the best performers, the most highly loaded species, a further 5 times making 10 consecutive uses in all. A strong dependence on the porous structure of the resins was demonstrated with the activity rising systemically with the surface area. The two highest surface area highest loaded species displayed good activity even when used for the tenth time. The level of concurrent alkene isomerization observed was low throughout (<1%) making these heterogeneous species selective and highly active. Overall the derived catalysts are excellent candidates for use in the research laboratory, and with further development could also be valuable in continuous processes.

Combinatorial Chemistry and High Throughput Screening published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Tunc, Sibel published the artcileInvestigation of interactions between some anionic dyes and cationic surfactants by conductometric method, COA of Formula: C19H34ClN, the publication is Fluid Phase Equilibria (2007), 251(1), 1-7, database is CAplus.

The interactions of cationic surfactants with anionic dyes were studied by conductometric method. Benzyltrimethylammonium chloride (BTMACl), benzyltriethylammonium chloride (BTEACl) and benzyltributylammonium chloride (BTBACl) were used as cationic surfactants and indigo carmine (IC) and amaranth (Amr) were chosen as anionic dyes. The specific conductance of dye-surfactant mixtures was measured at 25, 35 and 45 °C. A decrease in measured specific conductance values of dye-surfactant mixture was caused by the formation of non-conducting or less-conducting dye-surfactant complex. The equilibrium constants, K₁, the standard free energy changes, ΔG°₁ the standard enthalpy changes, ΔH°₁ and the standard entropy changes, ΔS°₁ for the first association step of dye-surfactant complex formation were calculated by a theor. model. The results showed that the equilibrium constants and the neg. standard free energy change values for all systems decreased as temperature increased. Also these values decreased for all systems studied with increasing alkyl chains of surfactants due to the steric effect. When the equilibrium constant values, K₁, for the first association step of IC-surfactant and Amr-surfactant systems with the same surfactant were compared, the values of K₁ for IC-surfactant system were higher than that of Amr-surfactant system.

Fluid Phase Equilibria published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C8H19NO2, COA of Formula: C19H34ClN.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shen, Hui published the artcileSynthesis of 3-substituted 2-oxindoles from secondary α-bromo-propionanilides via palladium-catalyzed intramolecular cyclization, Name: 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Organic & Biomolecular Chemistry (2022), 20(17), 3589-3597, database is CAplus and MEDLINE.

A palladium-catalyzed intramol. cyclization of α-bromo-propionanilides was developed, delivering a series of 3-substituted 2-oxindoles in high yields. The method features easy to prepare starting materials, broad substrate scope and excellent functional group tolerance. A detailed mechanistic investigation was performed.

Organic & Biomolecular Chemistry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C10H10O2, Name: 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Romero, F. Anthony published the artcilePotent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2007), 50(5), 1058-1068, database is CAplus and MEDLINE.

A study of the structure-activity relationships (SAR) of 2f (I, OL-135), a potent inhibitor of fatty acid amide hydrolase (FAAH), is detailed, targeting the 5-position of the oxazole. Examination of a series of substituted benzene derivatives (12-14) revealed that the optimal position for substitution was the meta-position with selected members approaching or exceeding the potency of 2f. Concurrent with these studies, the effect of substitution on the pyridine ring of 2f was also examined A series of small, nonaromatic C5-substituents was also explored and revealed that the K_i follows a well-defined correlation with the Hammett σ_p constant (ρ = 3.01, R² = 0.91) in which electron-withdrawing substituents enhance potency, leading to inhibitors with K_is as low as 400 pM (20n). Proteomic-wide screening of the inhibitors revealed that most are exquisitely selective for FAAH over all other mammalian proteases, reversing the 100-fold preference of 20a (C5 substituent = H) for the enzyme TGH.

Journal of Medicinal Chemistry published new progress about 5860-95-7. 5860-95-7 belongs to chlorides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Chloride,Benzene,Ketone, name is 1-(2-Chlorophenyl)-2,2,2-trifluoroethanone, and the molecular formula is C8H4ClF3O, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Qiu, Lin published the artcileSynthesis and in vitro evaluation of new TRPV4 ligands and biodistribution study of an ¹¹C-labeled radiotracer in rodents, Related Products of chlorides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(22), 127573, database is CAplus and MEDLINE.

Nine new compounds targeting the transient receptor potential vanilloid-4 (TRPV4) were synthesized and their biol. activities toward TRPV4 were determined using freshly isolated mouse skin macrophages through live cell Ca²⁺ imaging assay. Three compounds 4b, 4c, and 4i exhibited higher percentages of in vitro activation of TRPV4 as 48.1%, 59.3% and 33.5%, which are comparable to 56.4% activation response of the reported TRPV4 agonist GSK1016790A (3). The compound 4i was chosen for ¹¹C-radiosynthesis using its phenol precursor 4g to reacted with [¹¹C]methyl iodide. The radiosynthesis was achieved with good radiochem. yield (16 ± 5%), high chem. and radiochem. purity (>95%), and high molar activity (16-21 GBq/μmol, decay corrected to the end of bombardment, EOB n ≥ 4). Furthermore, the initial ex vivo biodistribution study in rats showed that [¹¹C]4i had higher uptake in kidney, liver and small intestine compared to other tissues with rapid washout.

Bioorganic & Medicinal Chemistry Letters published new progress about 254749-11-6. 254749-11-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Nitrile,Benzene, name is 2-Chloro-4-cyanobenzene-1-sulfonyl chloride, and the molecular formula is C7H3Cl2NO2S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brain, E. G. published the artcileDerivatives of 6-aminopenicillanic acid. IV. Analogs of 2,6-dimethoxyphenylpenicillin in the naphthalene and quinoline series, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid, the publication is Journal of the Chemical Society (1963), 491-7, database is CAplus.

cf. CA 57, 12458c. A number of sterically hindered alkoxynaphthoic and -quinolinecaxboxylic acids have been synthesized. Reaction of the acid chlorides with 6-aminopenicillanic acid gave substituted naphthyl- and quinolylpenicillins which resisted inactivation by penicillinase.

Journal of the Chemical Society published new progress about 36335-47-4. 36335-47-4 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene,Ether, name is 3-Chloro-2,6-dimethoxybenzoic acid, and the molecular formula is C9H9ClO4, Recommanded Product: 3-Chloro-2,6-dimethoxybenzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Corriu, R. J. P. published the artcileThe palladium-catalyzed cross-coupling polymerization of diethynylmethyl (n-octyl)silane with dihaloarenes, Synthetic Route of 14799-93-0, the publication is European Polymer Journal (1993), 29(12), 1563-9, database is CAplus.

Polymers of structure -[-CCSi(MeOctⁿ)CC-Z-]-_n(Z = 1,4-benzene, 4,4′-biphenyl, 9,10-anthracene, 2,7-fluorene, 2,5 and 2,6-pyridine, 6,6′-bipyridine, 2,5-thiophene, 2,6-p-dimethylaminonitrobenzene, 2,6-p-nitroaniline, 2,7-fluoren-9-one, p-tetrafluorobenzene, 2,6-p-nitrophenol or 2,6-p-cyanophenol) were prepared by reaction of diethynylmethyl(n-octyl)silane with the appropriate hetero(aromatic) dibromide or diiodide in the presence of (PPh₃)₂PdCl₂ and CuI. The polymer where Z = 6,6′-bipyridine reacted with copper(II) trifluoromethanesulfonate to give a copper(II)-containing polymer, reduction of which with hydrazine afforded the Cu(I)-containing polymer. The effect of change in reaction conditions on the cross-coupling polymerization was investigated. High mol. weights are favored by use of: (a) the diiodo- rather than the dibromoarene, (b) an equimolar mixture of the reactants or excess diethynylsilane, and in most cases (c) toluene cosolvent. The mol. weight passes through a maximum as the total catalyst concentration is increased, or as the individual Cu and Pd catalyst concentrations are sep. raised. The presence of tetraethylammonium chloride or high concentrations of triphenylphosphine reduces the mol. weight

European Polymer Journal published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, Synthetic Route of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Feng, Yan published the artcilePreparation and Capacity-Fading Investigation of Polymer-Derived Silicon Carbonitride Anode for Lithium-Ion Battery, COA of Formula: C9H20Cl2Si, the publication is ACS Omega (2017), 2(11), 8075-8085, database is CAplus and MEDLINE.

Polymer-derived silicon carbonitride (SiCN) materials have been synthesized via pyrolyzing from five poly(silylcarbondiimide)s with different contents of carbon (labeled as 1-5#). The morphol. and structure measurements show the SiCN materials are the mixtures of nanocrystals of SiC, Si3N4, and graphite. The SiCN materials have been used as anodes for lithium ion batteries (LIBs). Among the five polymer-derived SiCN materials, the 5#SiCN derived from dichloromethylvinylsilane and di-n-octyldichlorosilane, has the best cycle stability and high-rate performance at the low cut-off voltage of 0.01-1.0 V. In lithium-ion half-cells, the specific delithiation capacity of that 5#SiCN anode still remains at 826.7 mAh g-1 after 100 charge/discharge cycles; it can even deliver the capacity above 550 mAh g-1 at high current densities of 1.6 and 2 A g-1. In lithium-ion full cells, the 5#SiCN anode works well with NCM com. cathode. The outstanding electrochem. performance of 5#SiCN anode is attributed to two factors: (1) the formation of stable and compact SEI layer on the anode surface anode, which protects the electrode cracking during the charge/discharge cycling; (2) a large amount of carbon component the less Si3N4 phase in the 5#SiCN structure, which provides electrochem. reactive and conductive environment in the SiCN structure, benefits the lithiation/delithiation process. In addition, we explore the reason for the capacity fading of these SiCN anodes.

ACS Omega published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is C9H20Cl2Si, COA of Formula: C9H20Cl2Si.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wang, Xiao-Gang published the artcileA multifunctional metal-organic framework based tumor targeting drug delivery system for cancer therapy, COA of Formula: C19H14Cl2, the publication is Nanoscale (2015), 7(38), 16061-16070, database is CAplus and MEDLINE.

Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal-organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free “green” post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.

Nanoscale published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C10H9NO, COA of Formula: C19H14Cl2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Liu, Xing published the artcileChemoselective Chan-Lam Coupling Reactions between Benzimidazoline-2-thiones and Arylboronic Acids, Product Details of C7H8BClO2, the publication is Journal of Organic Chemistry (2019), 84(18), 11524-11532, database is CAplus and MEDLINE.

An efficient Chan-Lam-type methodol. for the selective synthesis of S-arylbenzimidazoles and N,S-diarylbenzimidazoles was developed. The selectivity was controlled by varying the amount of the catalyst Cu(OAc)₂·H₂O, temperature, and solvent switching. These transformations feature a simple protocol, broad functional group tolerance, high selectivity, and good to excellent yields. It is noteworthy that these reactions represent the first examples of the application of the selective Chan-Lam coupling.

Journal of Organic Chemistry published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Product Details of C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics