Month: December 2022

Karthiraj, T. published the artcileTask-specific deep eutectic solvent based extraction coupled cascade chromatography quantification of α-glucosidase inhibitory peptide from Ocimum tenuriflorum seeds, HPLC of Formula: 23616-79-7, the publication is Microchemical Journal (2020), 104883, database is CAplus.

A sustainable method for purification and quantification of α-glucosidase inhibitory peptides from Ocimum tenuriflorum is described in the present investigation. Nine tailor-made DESs under diverse categories were synthesized and their thermophys. properties were determined Selective extraction of these therapeutic peptides using sustainable DESs is carried out. Three DESs having better phase ratios were selected and their partition coefficient was assessed with a tripeptide as a marker. Ultrasound-assisted liquid-phase microextraction (UA-LPME) based purification of bioactive peptides is performed. Further, response surface methodol. based optimization for effective isolation of α-amylase inhibitory peptide from mango seed hydrolyzate for DES formed with carnitine and maltose was determined as 96%. Preparative purification (43μg/g) of bioactive peptides was carried out with size exclusion chromatog. The preconcd. fractions were exposed to anion exchange chromatog. and ultrapure peptides (88%) with high inhibitory activity were obtained. α-amylase inhibition kinetics was established for the resultant ultrapure bioactive peptides to evaluate and quantify its inhibitory property.

Microchemical Journal published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, HPLC of Formula: 23616-79-7.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sykes, Thomas C. published the artcileSubstrate Wettability Influences Internal Jet Formation and Mixing during Droplet Coalescence, Application In Synthesis of 14799-93-0, the publication is Langmuir (2020), 36(32), 9596-9607, database is CAplus and MEDLINE.

The internal dynamics during the axisym. coalescence of an initially static free droplet and a sessile droplet of the same fluid are studied using both laboratory experiments and numerical simulations. A high-speed camera captured internal flows from the side, visualized by adding a dye to the free droplet. The numerical simulations employ the volume of fluid method, with the Kistler dynamic contact angle model to capture substrate wettability, quant. validated against the image-processed experiments It is shown that an internal jet can be formed when capillary waves reflected from the contact line create a small tip with high curvature on top of the coalesced droplet that propels fluid toward the substrate. Jet formation is found to depend on the substrate wettability, which influences capillary wave reflection; the importance of the advancing contact angle subordinated to that of the receding contact angle. It is systematically shown via regime maps that jet formation is enhanced by increasing the receding contact angle and by decreasing the droplet viscosity. Jets are seen at volume ratios very different from those accepted for free droplets, showing that a substrate with appropriate wettability can improve the efficiency of fluid mixing.

Langmuir published new progress about 14799-93-0. 14799-93-0 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(methyl)(octyl)silane, and the molecular formula is 0, Application In Synthesis of 14799-93-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sumida, Yuto published the artcileBoron-Selective Biaryl Coupling Approach to Versatile Dibenzoxaborins and Application to Concise Synthesis of Defucogilvocarcin M, Formula: C7H8BClO2, the publication is Organic Letters (2014), 16(23), 6240-6243, database is CAplus and MEDLINE.

An efficient synthetic method for versatile dibenzoxaborins based on boron-selective Suzuki-Miyaura cross-coupling between o-borylphenols and aryl halides or triflates bearing a 1,8-diaminonaphthalene-protected o-boryl group is reported [e.g., I + II (dan = 1,8-diaminonaphthalene) â†?III (quant) using Pd(OAc)₂, CyJohnPhos as ligand and K₃PO₄ as base]. A short synthesis of defucogilvocarcin M (IV) was achieved using the proposed method in combination with several other boron-mediated transformations.

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C18H24N6O6S4, Formula: C7H8BClO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gerstenberger, Ina published the artcileRegioselective and stereoselective transformations of enantiopure para-benzoquinone equivalents, Synthetic Route of 5034-06-0, the publication is European Journal of Organic Chemistry (1998), 643-650, database is CAplus.

The selectivities of typical transformations of the 1,4-benzoquinone Diels-Alder adduct I (RR¹ = bond) and its dihydro derivative I (R, R¹ = H) are highly dependent on the mechanistic path followed. To avoid ambiguities and to make sure of clearly defined regioselectivity, 1,4-benzoquinone monoethylene ketal was examined and proven not only to be an excellent dienophile but, of course, also to lead to reliable regioselectivity in subsequent transformations. This led to the correction of an earlier provisional assignment of alkylation products.

European Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C3H9ClOS, Synthetic Route of 5034-06-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Binderup, E. published the artcileChlorosulfates as reagents in the synthesis of carboxylic acid esters under phase-transfer conditions, SDS of cas: 90906-61-9, the publication is Synthetic Communications (1984), 14(9), 857-64, database is CAplus.

Chlorosulfates ClSO₃R (R = CH₂Cl, Me, CHMeCl, Bu, Et) and (ClSO₃)₂CH₂ were used to esterify several carboxylic acids, i.e., penicillanic acid derivatives, BzOH, and alkanoic acids. Thus, penicillanic acid sulfone was converted to the chloromethyl ester by treatment with ClSO₃CH₂Cl in H₂O-CH₂Cl₂ in the presence of NaHCO₃ and Bu₄N⁺HSO₄^–.

Synthetic Communications published new progress about 90906-61-9. 90906-61-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1-Chloroethyl sulfochloridate, and the molecular formula is C2H4Cl2O3S, SDS of cas: 90906-61-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brueckner, Alexander C. published the artcileVisible-light-mediated, nitrogen-centered radical amination of tertiary alkyl halides under metal-free conditions to form α-tertiary amines, Application of 2-Chlorotrityl chloride, the publication is Organic & Biomolecular Chemistry (2016), 14(19), 4387-4392, database is CAplus and MEDLINE.

A mild and operationally convenient amino-functionalization of a range of tertiary alkyl halides by reaction with iminoiodinanes (PhI=NNs) and I₂ was developed. According to the mechanistic experiments described within the reaction was speculated to proceed through a light-promoted, N-centered radical pathway involving a N,N-diiodosulfonamide reactive species. This method of direct N-incorporation offers an attractive alternative to the production of α-tertiary amines, a synthetically challenging structural class found in a variety of bioactive mols.

Organic & Biomolecular Chemistry published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, Application of 2-Chlorotrityl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Ziyong published the artcileConstruction of photoswitchable rotaxanes and catenanes containing dithienylethene fragments, Related Products of chlorides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2015), 13(26), 7313-7322, database is CAplus and MEDLINE.

Mech. interlocked structures such as rotaxanes and catenanes provide a novel backbone for constructing functional materials with unique structural characteristics. In this study, we have designed and synthesized a series of photoswitchable rotaxanes and catenanes containing photochromic dithienylethene fragments using a template-directed clipping approach based on dynamic imine chem. Their structures have been confirmed using NMR, mass spectrometry and elemental anal. Investigations into their photoisomerization properties indicated that these dithienylethene-based mech. interlocked mols. have good reversibility and excellent fatigue resistance upon irradiation with UV or visible light. Interestingly, the mech. interlocked mols. containing two dithienylethene backbones display around a 2-fold increase in the molar absorption coefficient compared with that of the mono dithienylethene derivative Furthermore, the introduction of the fluorophore pyrene in the dithienylethene component facilitates these mols. to serve as fluorescent switches.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Junsheng published the artcileDesign, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase, Related Products of chlorides-buliding-blocks, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1123-1139, database is CAplus and MEDLINE.

N-arylthiazoleamines such as (arylamino)thiazolecarboxylates I (R = Ph, 4-MeOC₆H₄, 4-ClC₆H₄, 4-F₃CC₆H₄, 4-F₃CC₆H₄, 4-t-BuC₆H₄, 4-Cl-3-F₃CC₆H₃, 4-Br-3-F₃CC₆H₃, 3,4-Cl₂C₆H₃, 3,5-Cl₂C₆H₃, 4-Br-2-MeC₆H₃, 5-indanyl, 1,3-benzodioxol-5-yl, 5,6,7,8-tetrahydro-2-naphthyl, 2-naphthyl, 2-anthracenyl, 4-PhC₆H₄, 2-R¹-6-R²-4-R³C₆H₂, 3-Cl-4-R⁴OC₆H₃; R¹, R² = H, F; R³ = Ph, 3-MeOC₆H₄; R⁴ = Ph, PhCH₂, 2-Cl-6-FC₆H₃CH₂) were prepared as inhibitors of human dihydroorotate dehydrogenase (HsDHODH), a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases; their calculated and exptl. binding to HsDHODH and binding to the corresponding enzyme from Plasmodium falciparum were determined The structures of complexes of two arylaminotriazoles bound to HsDHODH were determined by X-ray crystallog.; the structures confirmed that the inhibitors bound at the putative ubiquinone binding tunnel and guided the development of improved analogs, such as I (R = 5-indanyl). I (R = 5-indanyl) inhibited inflammation and alleviated foot swelling in rats.

Journal of Medicinal Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C13H16O2, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhu, Junsheng published the artcileDesign, Synthesis, X-ray Crystallographic Analysis, and Biological Evaluation of Thiazole Derivatives as Potent and Selective Inhibitors of Human Dihydroorotate Dehydrogenase, Name: 3-Chloro-4-fluoronitrobenzene, the publication is Journal of Medicinal Chemistry (2015), 58(3), 1123-1139, database is CAplus and MEDLINE.

N-arylthiazoleamines such as (arylamino)thiazolecarboxylates I (R = Ph, 4-MeOC₆H₄, 4-ClC₆H₄, 4-F₃CC₆H₄, 4-F₃CC₆H₄, 4-t-BuC₆H₄, 4-Cl-3-F₃CC₆H₃, 4-Br-3-F₃CC₆H₃, 3,4-Cl₂C₆H₃, 3,5-Cl₂C₆H₃, 4-Br-2-MeC₆H₃, 5-indanyl, 1,3-benzodioxol-5-yl, 5,6,7,8-tetrahydro-2-naphthyl, 2-naphthyl, 2-anthracenyl, 4-PhC₆H₄, 2-R¹-6-R²-4-R³C₆H₂, 3-Cl-4-R⁴OC₆H₃; R¹, R² = H, F; R³ = Ph, 3-MeOC₆H₄; R⁴ = Ph, PhCH₂, 2-Cl-6-FC₆H₃CH₂) were prepared as inhibitors of human dihydroorotate dehydrogenase (HsDHODH), a potential therapeutic target for the treatment of rheumatoid arthritis and other autoimmune diseases; their calculated and exptl. binding to HsDHODH and binding to the corresponding enzyme from Plasmodium falciparum were determined The structures of complexes of two arylaminotriazoles bound to HsDHODH were determined by X-ray crystallog.; the structures confirmed that the inhibitors bound at the putative ubiquinone binding tunnel and guided the development of improved analogs, such as I (R = 5-indanyl). I (R = 5-indanyl) inhibited inflammation and alleviated foot swelling in rats.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C5H10Cl3O3P, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kang, Seung-Hyun published the artcilePhosphonium Chloride-Catalyzed Dehydrochlorinative Coupling Reactions of Alkyl Halides with Hydridochlorosilanes, Name: Dichloro(hexyl)(methyl)silane, the publication is Organometallics (2003), 22(3), 529-534, database is CAplus.

The dehydrochlorinative Si-C coupling reactions of various primary and secondary alkyl chlorides with hydridochlorosilanes in the presence of tetrabutylphosphonium chloride as catalyst gave the coupling products with elimination of HCl as a gas. For example, RCl (R = CH₂C₆H₄X-p; X = H, Cl, F, Me, MeO), when coupled with HSiCl₃ in the presence of catalytic amounts of phosphonium salts [Bu₄Y]Z (Y = P, N; Z = Cl, Br, I) gave RSiCl₃ (R = same as above) in 80-96% yields. Coupling reactions of activated alkyl chlorides such as benzyl chlorides proceeded at 130°, while unactivated organic chlorides such as silylalkyl chlorides and secondary alkyl chlorides required higher reaction temperatures of 150 or 170° and longer reaction times. Primary alkyl chlorides reacted with trichlorosilane (1) to give coupling products in good to excellent yields, but secondary alkyl chlorides reacted at a slower rate and gave lower yields of products. Coupling reactions with methyldichlorosilane instead of 1 proceeded at slower rates and gave lower yields of products.

Organometallics published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Name: Dichloro(hexyl)(methyl)silane.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics