Month: December 2022

Ballari, Maria Sol published the artcileOne-pot sequential synthesis and antifungal activity of 2-(benzylsulfonyl)benzothiazole derivatives, Category: chlorides-buliding-blocks, the publication is RSC Advances (2019), 9(50), 29405-29413, database is CAplus.

A series of 2-(benzylsulfonyl)benzothiazoles I [R = H, 4-F, 2-I, etc.; X = S] was synthesized by an environmentally friendly method, using water as reaction medium via one-pot and two-step procedure, starting from 2-mercaptobenzothiazole and benzyl halides. Few compounds of 2-(benzylsulfonyl)benzoxazoles I [X = O] were successfully synthesized via oxidation of 2-(benzoxazolyl)benzylsulfides. The potential fungicides were tested against a panel of phytopathogenic fungi, with many of them showing a significant improvement compared to the non-oxidized analogs and the com. antifungal Captan. The new derivatives I [R = 4-Me, 2-Cl; X = S] presented remarkable properties, being able to inhibit the growth of two resistant molds (A. fumigatus and A. ustus). Compounds I [R = 4-Me, 2-Cl; X = S] could be classified as broad-spectrum fungicides, emerging as possible candidates for the control of these molds, which had neg. impact in food production

RSC Advances published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Serrano, Jose S. published the artcileCompared efficacy of quinidine, GABA and N-trimethyl GABA upon a model of ventricular automaticity, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Methods and Findings in Experimental and Clinical Pharmacology (1983), 5(4), 251-4, database is CAplus and MEDLINE.

The effects of GABA  [56-12-2], its quaternary derivative N-trimethyl-GABA  [10329-41-6], and quinidine  [56-54-2] were studied in a model of ventricular automaticity induced in the isolated ventricle of the rat. GABA showed low antiautomatic activity. N-Trimethyl-GABA and quinidine were, however, very effective drugs in the reduction of the automatic ventricular rate. The efficacies of the latter 2 drugs at 5 × 10^-5 M were not significantly different. Thus, N-trimethyl-GABA has antiautomatic activity in this exptl. model similar to that of the classic antidysrhythmic drug quinidine.

Methods and Findings in Experimental and Clinical Pharmacology published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C10H7NO3, Recommanded Product: 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bailey, William J. published the artcilePyrolysis of esters. XXII. Synthesis of bisdienes from 2-hydroxymethyl-1,3-butadiene, Quality Control of 866-23-9, the publication is Journal of Organic Chemistry (1962), 2732-6, database is CAplus.

cf. CA 57, 4529d. A new synthesis of 2-hydroxymethyl-1,3-butadiene was developed, starting from commercially available 2-amino-2-ethyl-1,3-propanediol and involving a pyrolysis of an amine oxide as well as the pyrolysis of an ester. Hydroxymethylbutadiene treated with vinyl acetate in the presence of a mercuric oxide-boron trifluoride etherate mixture gave 38% bis(2-butadienylmethyl) acetal. Treatment of the hydroxymethylbutadiene with hexamethylene diisocyanate gave 76% solid bis(2-butadienylmethyl) hexamethylenecarbamate, while treatment with m-xylylene diisocyanate gave 91% solid bis(2-butadienylmethyl) m-xylylenecarbamate.

Journal of Organic Chemistry published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Axer, Alexander published the artcileHarnessing the Maltodextrin Transport Mechanism for Targeted Bacterial Imaging: Structural Requirements for Improved in vivo Stability in Tracer Design, Application In Synthesis of 21286-54-4, the publication is ChemMedChem (2018), 13(3), 241-250, database is CAplus and MEDLINE.

Diagnosis and localization of bacterial infections remains a significant clin. challenge. Harnessing bacteria-specific metabolic pathways, such as the maltodextrin transport mechanism, may allow specific localization and imaging of small or hidden colonies. This requires that the intrabacterial tracer accumulation provided by the transporter is matched by high serum stability of the tracer mol. Herein, radiolabeled maltodextrins of varying chain lengths and with free nonreducing/reducing ends are reported and their behavior against starch-degrading enzymes in the blood, which compromise their serum stability, is evaluated. Successful single-photon emission computed tomog. (SPECT) imaging is shown in a footpad infection model in vivo by using the newly developed model tracer, [^99mTc]MB1143, and the signal is compared with that of ¹⁸F-fluorodeoxyglucose positron emission tomog. ([¹⁸F]FDG-PET) as a nonbacterial specific marker for inflammation. Although the [^99mTc]MB1143 imaging signal is highly specific, it is low, most probably due to insufficient serum stability of the tracer. A series of stability tests with different ¹⁸F-labeled maltodextrins finally yielded clear structural guidelines regarding substitution patterns and chain lengths of maltodextrin-based tracers for nuclear imaging of bacterial infections.

ChemMedChem published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Application In Synthesis of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Stutz, Helmut published the artcilePhostones with potential alkylating properties, Recommanded Product: Diethyltrichloromethylphosphonate, the publication is Zeitschrift fuer Chemie (1975), 15(2), 52-4, database is CAplus.

The reaction of (EtO)2PR with HO(CH2)4Cl gave phostones I [n = 2, R = EtO (II), Ph]. The cyclization of XCH2(CH2)nCH2P(O)(OEt)R (X = halo) gave phostones I (n = 1, 2; R = PhO, Cl3C). II was chlorinated with PCl5 to give I (n = 2, R = Cl). Thiourea and 2-mercaptobenzimidazole were S-alkylated and aniline and piperidine were N-alkylated with I.

Zeitschrift fuer Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C44H28ClFeN4, Recommanded Product: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Elssner, Thomas published the artcileIsolation, Identification, and Synthesis of γ-Butyrobetainyl-CoA and Crotonobetainyl-CoA, Compounds Involved in Carnitine Metabolism of E. coli, Product Details of C7H16ClNO2, the publication is Biochemistry (2000), 39(35), 10761-10769, database is CAplus and MEDLINE.

A still unknown low-mol.-mass cofactor essential for the activity of carnitine-metabolizing enzymes (e.g., L-carnitine dehydratase, crotonobetaine reductase) from E. coli has been purified to homogeneity from a cell-free extract of E. coli O44K74. The purity of the cofactor was confirmed by HPLC anal. Biosynthesis of the unknown compound was only observed when bacteria were cultivated anaerobically in the presence of L-carnitine or crotonobetaine. The determined properties, together with results obtained from UV-visible, ¹H NMR, and mass spectrometry, indicate that the compound in question is a new CoA derivative The esterified compound was suggested to be γ-butyrobetaine – a metabolite of carnitine metabolism of E. coli. Proof of structure was performed by chem. synthesis. Besides γ-butyrobetainyl-CoA, a second new CoA derivative, crotonobetainyl-CoA, was also chem. synthesized. Both CoA derivatives were purified and their structures confirmed using NMR and mass spectrometry. Comparisons of structural data and of the chem. properties of γ-butyrobetainyl-CoA, crotonobetainyl-CoA, and the isolated cofactor verified that the unknown compound is γ-butyrobetainyl-CoA. The phys. and chem. properties of γ-butyrobetainyl-CoA and crotonobetainyl-CoA are similar to known CoA derivatives

Biochemistry published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Product Details of C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Thoma, William J. published the artcileEffect of vitamin C deficiency on hydroxylation of trimethylaminobutyrate to carnitine in the guinea pig, SDS of cas: 6249-56-5, the publication is Biochimica et Biophysica Acta, General Subjects (1984), 797(1), 136-9, database is CAplus and MEDLINE.

The effect of ascorbate  [50-81-7] deficiency on carnitine  [541-15-1] biosynthesis was investigated in young male guinea pigs. Liver and skeletal muscle carnitine levels were reduced in scorbutic animals. Heart and kidney concentrations remained unchanged. ¹⁴C-labeled 4-N-trimethylaminobutyrate  [407-64-7] was administered to controls, pair-fed, and scorbutic animals and distribution of isotope in compounds present in the liver after 30 min was determined Control and pair-fed animals converted trimethylaminobutyrate to carnitine faster than scorbutic animals. Injection of ascorbate with the [¹⁴C]trimethylaminobutyrate reversed the decline in trimethylaminobutyrate hydroxylase (EC 1.14.11.1) [56803-11-3] activity in scorbutic animals.

Biochimica et Biophysica Acta, General Subjects published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C9H5Cl2F3, SDS of cas: 6249-56-5.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gross, Carol J. published the artcileUptake of L-carnitine, D-carnitine and acetyl-L-carnitine by isolated guinea pig enterocytes, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Biochimica et Biophysica Acta, Molecular Cell Research (1986), 886(3), 425-33, database is CAplus and MEDLINE.

Uptake and metabolism of D– and L– isomers of carnitine (I), and acetyl-L–I were studied in isolated guinea pig enterocytes. Uptake of the D– and L-isomers of I was temperature dependent. Uptake of L-[¹⁴C]I by jejunal cells was Na⁺ dependent since replacement by Li⁺, K⁺, or choline greatly reduced uptake. L– And D–I developed intracellular-to-extracellular concentration gradients for total I (free plus acetylated) of 2.7 and 1.4, resp. However, acetylation of L–I accounted almost entirely for the difference between uptake of L– and D–I. About 60% of the intracellular label was acetyl-L–I after 30 min, and the remainder was free L–I. No other products were observed D–I was not metabolized. Acetyl-L–I was deacetylated during or immediately after uptake into intestinal cells and a portion of this newly formed intracellular free I was apparently reacetylated. L– And D–I transport (after adjustment for metabolism and diffusion) was evaluated over a concentration range of 2-1000 μM. K_m Values of 6-7 μM and 5 μM were estimated for L– and D–I, resp. Ileal cell uptake was âˆ?/2 that found for jejunal cells, but the labeled intracellular acetyl-I-to-I ratios were similar for both cell populations. I transport by guinea pig enterocytes demonstrated characteristics of a carrier-mediated process since it was inhibited by D–I and trimethylaminobutyrate, as well as being temperature and concentration dependent. The process appeared to be facilitated diffusion rather than active transport since L–I did not develop a significant concentration gradient and was unaffected by ouabain or actinomycin A.

Biochimica et Biophysica Acta, Molecular Cell Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Veisi, Hojat published the artcileHighly efficient method for synthesis of bis(indolyl)methanes catalyzed by FeCl₃-based ionic liquid, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Journal of the Chinese Chemical Society (Taipei, Taiwan) (2009), 56(2), 240-245, database is CAplus.

A reaction of benzyltriethylammonium chloride with iron chloride (FeCl₃) gave an ionic liquid compound [i.e., N,N,N-triethylbenzenemethanaminium tetrachloroferrate]. A method for the synthesis of the title compounds [i.e, 3,3′-(phenylmethylene)bis[1H-indole] derivatives] is reported here. A highly efficient green protocol involved a reaction of indole with with aldehydes and ketones in the presence of and ionic liquid These liquids serve as efficient media as well as Lewis acid catalysts.

Journal of the Chinese Chemical Society (Taipei, Taiwan) published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C12H10F2Si, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jansen, Koen published the artcileExtended Structure-Activity Relationship and Pharmacokinetic Investigation of (4-Quinolinoyl)glycyl-2-cyanopyrrolidine Inhibitors of Fibroblast Activation Protein (FAP), Recommanded Product: 2-Chloroisonicotinic acid, the publication is Journal of Medicinal Chemistry (2014), 57(7), 3053-3074, database is CAplus and MEDLINE.

Fibroblast activation protein (FAP) is a serine protease related to dipeptidyl peptidase IV (DPPIV). It has been convincingly linked to multiple disease states involving remodeling of the extracellular matrix. FAP inhibition is investigated as a therapeutic option for several of these diseases, with most attention so far devoted to oncol. applications. The authors previously discovered the N-4-quinolinoyl-Gly-(2S)-cyanoPro scaffold as a possible entry to highly potent and selective FAP inhibitors. In the present study, the authors explore in detail the structure-activity relationship around this core scaffold. The authors report extensively optimized compounds that display low nanomolar inhibitory potency and high selectivity against the related dipeptidyl peptidases (DPPs) DPPIV, DPP9, DPPII, and prolyl oligopeptidase (PREP). The log D values, plasma stabilities, and microsomal stabilities of selected compounds were found to be highly satisfactory. Pharmacokinetic evaluation in mice of selected inhibitors demonstrated high oral bioavailability, plasma half-life, and the potential to selectively and completely inhibit FAP in vivo.

Journal of Medicinal Chemistry published new progress about 6313-54-8. 6313-54-8 belongs to chlorides-buliding-blocks, auxiliary class Pyridine,Chloride,Carboxylic acid, name is 2-Chloroisonicotinic acid, and the molecular formula is C6H4ClNO2, Recommanded Product: 2-Chloroisonicotinic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics