Month: December 2022

Chen, Haifeng et al. published their research in Angewandte Chemie, International Edition in 2022 | CAS: 6294-17-3

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 1-Bromo-6-chlorohexane

Reactivity in Nickel-Catalyzed Multi-component Sequential Reductive Cross-Coupling Reactions was written by Chen, Haifeng;Yue, Huifeng;Zhu, Chen;Rueping, Magnus. And the article was included in Angewandte Chemie, International Edition in 2022.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

The nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and Et chloroformate is described. Et chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Exptl. and DFT mechanistic studies highlight the complexity of the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate, and alkyl halide. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oh, Youri et al. published their research in International Journal of Molecular Sciences in 2021 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C6H9ClO3

Design and synthesis of a novel PLK1 inhibitor scaffold using a hybridized 3D-QSAR model was written by Oh, Youri;Jung, Hoyong;Kim, Hyejin;Baek, Jihyun;Jun, Joonhong;Cho, Hyunwook;Im, Daseul;Hah, Jung-Mi. And the article was included in International Journal of Molecular Sciences in 2021.Synthetic Route of C6H9ClO3 The following contents are mentioned in the article:

Polo-like kinase 1 (PLK1) plays an important role in cell cycle progression and proliferation in cancer cells. PLK1 also contributes to anticancer drug resistance and is a valuable target in anticancer therapeutics. To identify addnl. effective PLK1 inhibitors, we performed QSAR studies of two series of known PLK1 inhibitors and proposed a new structure based on a hybridized 3D-QSAR model. Given the hybridized 3D-QSAR models, we designed and synthesized 4-benzyloxy-1-(2-arylaminopyridin-4-yl)-1H-pyrazole-3-carboxamides, and we inspected its inhibitory activities to identify novel PLK1 inhibitors with decent potency and selectivity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Synthetic Route of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Synthetic Route of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wu, Hao et al. published their research in Synthetic Communications in 2021 | CAS: 1186603-47-3

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 1186603-47-3

A concise synthesis of 10-benzoyl-3,4-dihydroanthracen-1(2H)-one derivatives catalyzed by TfOH under metal-free conditions was written by Wu, Hao;Chen, Hua-Dong;Liu, Jian-Quan;Li, Qiu-Yan;Wang, Xiang-Shan. And the article was included in Synthetic Communications in 2021.Product Details of 1186603-47-3 The following contents are mentioned in the article:

TfOH was proved to be an efficient catalyst to promote the intra-mol. cyclization, Diels-Alder reaction, deprotonation and dehydration and provided a synthesis of 10-benzoyl-3,4-dihydroanthracen-1(2H)-ones I [R = Ph, 4-FC6H4, 4-EtC6H4, etc.; R1 = H, 7-F, 6-Cl, etc.; R2 = H; R3 = Ph; R2 = R3 = Me; R4 = H, Me] in good yields from a reaction of 2-(phenylethynyl) benzaldehyde and cyclohexane-1,3-dione. It underwent in high regioselectivity when center asym. 4,4-dimethylcyclohexane-1,3-dione was used as a reactant. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Product Details of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Haszeldine, Robert N.’s team published research in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) in | CAS: 1002-41-1

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Category: chlorides-buliding-blocks.

Haszeldine, Robert N. published the artcilePerfluoroalkyl derivatives of sulfur. Part XIX. Reaction of fluoroolefins with fluoride ion in the presence of dimethyl disulfide, and related reactions, Category: chlorides-buliding-blocks, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1976), 1178-82, database is CAplus.

F2C:CF2 reacted with CsF in the presence of MeS2Me to give 15% CF3CFRSMe (I; R = F), 77% MeSCF2CFRSMe (II; R = F), and 2% CF3CF2H, whereas F2C:CFCl gave 15% I (R = Cl), 56% II (R = Cl) and 13% of a mixture (III) of cis- and trans-MeSCF:CFR (R = Cl. Under similar conditions CF3CF:CF2 gave 38% I (R = CF3) and 12-21% III (R = CF3) together with olefin telomers. F2C:CF2 with CsF in the presence of Me2S gave only CF3CF2H. F2C:CFCl and CF3CF:CF2 reacted with NaSMe in Et2O at -196° to give 77 and 90% III, resp.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 1002-41-1. 1002-41-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is 1,2-Bis(2-chloroethyl)disulfane, and the molecular formula is C4H8Cl2S2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Kosmalski, Tomasz’s team published research in Molecules in 27 | CAS: 939-99-1

Molecules published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Kosmalski, Tomasz published the artcileThe Oxime Ethers with Heterocyclic, Alicyclic and Aromatic Moiety as Potential Anti-Cancer Agents, HPLC of Formula: 939-99-1, the publication is Molecules (2022), 27(4), 1374, database is CAplus and MEDLINE.

Chemotherapy is one of the most commonly used methods of cancer disease treatment. Due to the acquisition of drug resistance and the possibility of cancer recurrence, there is an urgent need to search for new mols. that would be more effective in destroying cancer cells. In this study, 1-(benzofuran-2-yl)ethan-1-one oxime and 26 oxime ethers containing heterocyclic, alicyclic or aromatic moiety were screened for their cytotoxicity against HeLa cancer cell line. The most promising derivatives with potential antitumor activity were 2-(cyclohexylideneaminoxy)acetic acid (18) and (E)-acetophenone O-2-morpholinoethyl oxime (22), which reduced the viability of HeLa cells below 20% of control at concentrations of 100-250 μg/mL. Some oxime ethers, namely thiazole and benzothiophene derivatives (24-27), also reduced HeLa cell viability at similar concentrations but with lower efficiency. Further cytotoxicity evaluation confirmed the specific toxicity of (E)-acetophenone O-2-morpholinoethyl oxime (22) against A-549, Caco-2, and HeLa cancer cells, with an EC50 around 7 μg/mL (30 μM). The most potent and specific compound was (E)-1-(benzothiophene-2-yl)ethanone O-4-methoxybenzyl oxime (27), which was selective for Caco-2 (with EC50 116 μg/mL) and HeLa (with EC50 28 μg/mL) cells. Considering the bioavailability parameters, the tested derivatives meet the criteria for good absorption and permeation. The presented results allow us to conclude that oxime ethers deserve more scientific attention and further research on their chemotherapeutic activity.

Molecules published new progress about 939-99-1. 939-99-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Benzyl chloride,Benzene, name is 1-(Chloromethyl)-4-(trifluoromethyl)benzene, and the molecular formula is C8H6ClF3, HPLC of Formula: 939-99-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Boutevin, B.’s team published research in Phosphorus and Sulfur and the Related Elements in 11 | CAS: 866-23-9

Phosphorus and Sulfur and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Boutevin, B. published the artcileSynthesis of phosphonic compounds with chlorofluorinated chains. Part I, Formula: C5H10Cl3O3P, the publication is Phosphorus and Sulfur and the Related Elements (1981), 11(3), 373-81, database is CAplus.

The redox catalysis and free-radical telomerizations of di- and trichloromethylphosphonyl dichlorides and their esters with chlorotrifluoroethylene (I) [79-38-9] were studied. Also investigated was phosphonation of telomers of I and CCl4 using Kinnear-Perren and Michaelis-Arbuzov methods. Phosphonic compounds containing chlorofluorinated blocks are obtained with these two methods. By-products are described and explained using known mechanisms.

Phosphorus and Sulfur and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Formula: C5H10Cl3O3P.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, Steffen’s team published research in Phosphorus, Sulfur and Silicon and the Related Elements in 62 | CAS: 866-23-9

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Albrecht, Steffen published the artcileDirect synthesis of dialkyl N,N-diorganophosphoramidates from trialkyl phosphites, Application In Synthesis of 866-23-9, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (1991), 62(1-4), 189-92, database is CAplus.

Amidation of (RO)3P (R = Et, Bu) with secondary amines R1R2NH (R1 = R2 = Bu, Et; R1 = Ph, R2 = Me, Et) in the presence of amine hydrochloride catalysts and CCl4 in MeCN as solvent gave title compounds, (RO)2P(O)(NR1R2). The mechanism is discussed.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Application In Synthesis of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Steinbach, J.’s team published research in Zeitschrift fuer Anorganische und Allgemeine Chemie in 523 | CAS: 866-23-9

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C14H10O4S2, Name: Diethyltrichloromethylphosphonate.

Steinbach, J. published the artcileReaction of the two-component system trialkyl phosphite/carbon tetrachloride with nucleophiles containing hydrogen. 2. Reaction with ammonia and amines, Name: Diethyltrichloromethylphosphonate, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1985), 180-6, database is CAplus.

RNH2 (R = H, Pr, Bu, PhCH2, Ph) reacted 1:1 with (R1O)3P (R1 = Et, Bu) and CCl4 to give (R1O)2P(O)NHR. If excess RNH2 was used, R1OP(O)(NHR)2 and OP(NHR)3 also formed. The reaction of (R1O)3P/CCl4 in the presence of secondary and tertiary amines gave (R1O)2P(O)CCl3, which reacted with the amine to give [Cl3CP(O)(O–)(OR1)][+NRR2R3R4].

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C14H10O4S2, Name: Diethyltrichloromethylphosphonate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, S.’s team published research in Zeitschrift fuer Anorganische und Allgemeine Chemie in 552 | CAS: 866-23-9

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Albrecht, S. published the artcileReaction of the two-component system trialkyl phosphite/carbon tetrachloride with nucleophiles. 3. Reaction in presence of trialkylammonium salts, SDS of cas: 866-23-9, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1987), 132-46, database is CAplus.

Alkali pseudohalides (KSCN, NaN3, KCN) react with the 2-component system trialkyl phosphite/carbon tetrachloride in the presence of trialkylammonium halides. Isothiocyanates of dialkylphosphoric acid, N-alkyl phosphoric acid diester amides, N-dialkoxyphosphoryl trialkoxyphosphazenes and tricyanophosphine oxide resp., are obtained. In the system (RO)3P/CCl4/R3NHI the dialkoxyphosphoryl chloride is formed.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Albrecht, S.’s team published research in Zeitschrift fuer Anorganische und Allgemeine Chemie in 538 | CAS: 866-23-9

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Albrecht, S. published the artcileReactions of chloro-substituted methanephosphonic acid dialkyl esters with dialkyl phosphites, trialkyl phosphites, or alcohol/sodium alcoholate, Quality Control of 866-23-9, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1986), 207-11, database is CAplus.

(RO)2P(O)CCl3 (R = Et, Bu) react with dialkyl phosphites and alc. in the presence of tertiary amines or with trialkyl phosphites and alc. yielding diesters of dichloromethanephosphonic acids and triesters of phosphoric acid. When esters of trichloromethane- or dichloromethanephosphonic acid react with alcs. in the presence of sodium alcoholates, a quant. cleavage of P-C bond occurs, and triesters of phosphoric acid and CHCl3 or CH2Cl2 are formed.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, Quality Control of 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics