Month: December 2022

Gold-Catalyzed One-Pot A³-Coupling/1,5-Hydride Shift/Schmittel-Type Cyclization: From Aldehydes, Amines and Alkynes to the Synthesis of Benzo[b]fluorenes was written by Lustosa, Danilo M.;Hartmann, Deborah;Rudolph, Matthias;Rominger, Frank;Hashmi, A. Stephen K.. And the article was included in European Journal of Organic Chemistry in 2020.Related Products of 1186603-47-3 The following contents are mentioned in the article:

A step-economic gold-catalyzed one-pot synthesis of benzo[b]fluorenes was described from aldehydes, alkynes and amines via an A³-coupling/1,5-hydride shift/Schmittel-type cyclization. The formation of the allene intermediate was not dependent on a previous installation of reaction triggers and upon cyclization delivered benzo[b]fluorenes. With this method, just by an easy modification of the starting materials in a modular way, nineteen benzo[b]fluorenes bearing different substituents Ar¹, Ar² and Ar³, were prepared Overall, three new carbon-carbon bonds were formed in one-pot. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Related Products of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Related Products of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Photoexcited Direct Amination/Amidation of Inert Csp³-H Bonds via Tungsten-Nickel Catalytic Relay was written by Wang, Qing;Ni, Shengyang;Yu, Lei;Pan, Yi;Wang, Yi. And the article was included in ACS Catalysis in 2022.Application of 7447-41-8 The following contents are mentioned in the article:

Light alkanes are the most abundant resources in nature. It is of great significance to develop convenient methods to realize the conversion of alkanes to high value-added products. However, the examples of aliphatic amines derived from unactivated alkanes remain rare. This work describes a rapid construction of C(sp³)-N bonds from light alkanes with amine/amide electrophile reagents via high-valent tungsten and nickel catalysis in high efficiency. The photoexcited metal relay provides a powerful tool for the activation of inert sp³-hybridized C-H bonds and stabilization of C-Ni(III)-N intermediates. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Application of 7447-41-8).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 7447-41-8

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Access to 3-alkylselenindoles by multicomponent reaction of indoles, selenium powder and unactivated alkyl halides under transition-metal-free conditions was written by Liu, Huan;Cai, Zhong-Jian;Ji, Shun-Jun. And the article was included in Chinese Chemical Letters in 2022.Product Details of 6294-17-3 The following contents are mentioned in the article:

Herein, a convenient and efficient multicomponent reaction of indoles, selenium powder and unactivated alkyl halides is reported. This protocol provides a practical, and facile approach for the synthesis of 3-alkylselenindole derivatives The advantages of this strategy include mild and transition-metal-free conditions, broad functional group tolerance, the use of simple and easily accessible selenium powder and alkyl halides as coupling partners. More importantly, the reaction proceeded smoothly with a large scale (> 10 g, > 90% yield), which further highlighted the potential application of this selenation strategy. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The genotoxicity of selected heterocyclic nitrogen compounds. A quantitative structure-activity relationship study was written by Zhu, C. M.;Kong, L. R.;Shen, Q. L.;Zhang, M.;Chen, J. W.;Huang, Q. G.;Wang, L. S.. And the article was included in Toxicological and Environmental Chemistry in 1998.Recommanded Product: 2272-40-4 The following contents are mentioned in the article:

The genotoxicity of heterocyclic N compounds was evaluated by micronuclei test of Vicia faba root tip cell. All these chems. are genotoxic. A meaningful Quant. Structure-Activity Relationship (QSAR) model was proposed by the quantum chem. descriptors: MN = -0.467-3.198 Elumo + 9.732q⁺. The above equation is significant because of its great RE and F values. It may reveal the mutagenic mechanism to some extent and can be used to describe the genotoxicity of 13 tested chems. The main key steps are metabolic course and mutagenic reaction. The chem. with higher q⁺ and lower Elumo has greater genotoxicity. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Recommanded Product: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxygenated Cyclopentenones via the Pauson-Khand Reaction of Silyl Enol Ether Substrates was written by Shaw, Paul;Hassell-Hart, Storm J.;Douglas, Gayle E.;Malcolm, Andrew G.;Kennedy, Alan R.;White, Gemma V.;Paterson, Laura C.;Kerr, William J.. And the article was included in Organic Letters in 2022.HPLC of Formula: 638-07-3 The following contents are mentioned in the article:

Here the application of silyl enol ether moieties as efficient alkene coupling partners within cobalt-mediated intramol. Pauson-Khand reactions is reported. This cyclization strategy delivers synthetically valuable oxygenated cyclopentenone products, e.g., I, in yields of ≤93% from both ketone- and aldehyde-derived silyl enol ethers, e.g., II, incorporates both terminal and internal alkyne partners, and delivers a variety of decorated systems, including more complex tricyclic structures. Facile removal of the silyl protecting group reveals oxygenated sites for potential further elaboration. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3HPLC of Formula: 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.HPLC of Formula: 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and biological evaluation of some new chalcones and their derivatives was written by Solankee, Anjani;Kapadia, Kishor;Thakor, Indrajit;Patel, Jayesh;Lad, Smruti. And the article was included in Asian Journal of Chemistry in 2004.SDS of cas: 2272-40-4 The following contents are mentioned in the article:

Novel α,β-unsaturated ketone-functionalized tris(amino)triazines I (R¹ = 4-FC₆H₄; R² = 3-ClC₆H₄, 2-O₂NC₆H₄, 2-furyl, 3-pyridyl, etc.) were synthesized by Claisen-Schmidt condensation between the Me ketone and aldehydes R²CHO. Further cyclocondensation of I with phenylhydrazine hydrochloride or thiourea in the basic medium gave pyrazolines II and mercaptopyrimidines III, resp. The products have been screened for their antibacterial activity in vitro. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4SDS of cas: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).SDS of cas: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Merging [2+2] Cycloaddition with Radical 1,4-Addition: Metal-Free Access to Functionalized Cyclobuta[a]naphthalen-4-ols was written by Liu, Feng;Wang, Jia-Yin;Zhou, Peng;Li, Guigen;Hao, Wen-Juan;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Angewandte Chemie, International Edition in 2017.Computed Properties of C15H9ClO The following contents are mentioned in the article:

A metal-free [2+2] cycloaddition and 1,4-addition sequence induced by S-centered radicals has been achieved by treating benzene-linked allene-ynes with aryldiazonium tetrafluoroborates and DABCO-bis(sulfur dioxide) in a one-pot procedure. The reaction provides a greener and more practical access to functionalized cyclobuta[a]naphthalen-4-ols with valuable applications. More than 50 examples are demonstrated with excellent diastereoselectivity and chem. yields. The reaction pathway is proposed to proceed by the following steps:[2+2] cycloaddition, insertion of SO₂, 1,4-addition, diazotization, and tautomerization. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Computed Properties of C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Benzylamines: synthesis and evaluation of antimycobacterial properties was written by Meindl, Wolfgang R.;Von Angerer, Erwin;Schoenenberger, Helmut;Ruckdeschel, Gotthard. And the article was included in Journal of Medicinal Chemistry in 1984.Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine The following contents are mentioned in the article:

The synthesis of benzylamines with various N-alkyl chains and substituents in the aromatic system as well as their evaluation on Mycobacterium tuberculosis H 37 Ra were described. The most active compounds: I.HCl (MIC 10.2 μg/mL), II. HCl (MIC 10.2 μg/mL), and III.HCl (MIC 6.4 μg/mL), also had a marked inhibitory effect on M. marinum and M. lufu. The combination of II with aminosalicylic acid, streptomycin, or dapsone had marked supra-additive effects on M. tuberculosis H 37 Ra. This study involved multiple reactions and reactants, such as 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine (cas: 90390-34-4Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine).

1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine (cas: 90390-34-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 1-(3-Chloro-5-fluorophenyl)-N-methylmethanamine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

New visible light excitable donor-acceptor 7-hydroxy-coumarins as blue fluorescent probes for selective staining of vacuoles in yeasts and L. donovani was written by Raghuvanshi, Ashutosh;Kumar Jha, Ajay;Kathuria, Manoj;Priya Awasthi, Bhanu;Purohit, Deepak;Mitra, Kalyan;Goel, Atul. And the article was included in Journal of Materials Chemistry B in 2017.Application of 95-88-5 The following contents are mentioned in the article:

In order to address the existing limitations of the com. available fluorescent probe CMAC (7-amino-4-chloromethylcoumarin), a new series of highly fluorescent donor-acceptor 7-hydroxy-coumarin derivatives was prepared and these derivatives were used as vacuole specific fluorescent probes for live cell imaging of unicellular parasitic protozoa L. donovani promastigotes and yeast cells S. pombe and S. cerevisiae. The synthesized 7-hydroxy-coumarins exhibited interesting photophys. properties and have advantages such as excitation in the visible region, good water solubility, photo-stability, good quantum yield and low cytotoxicity. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application of 95-88-5).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application of 95-88-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Facile synthesis of polymerized ionic liquids with high thermal stability was written by Hsieh, Yu-Nung;Kuei, Chun-Hsiung;Chou, Yu-Kai;Liu, Chia-Chyuan;Leu, Kuen-Lin;Yang, Tasi-Hsiu;Wang, Mei-Ying;Ho, Wen-Yueh. And the article was included in Tetrahedron Letters in 2010.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Twelve main-chain-type polymerized ionic liquids that have alkylimidazolium cation units were prepared using simple synthetic processes. The polymers were prepared using the self-polymerization of a single monomer; no polymerization initiators were required. The thermal stability and solvent miscibility of these polymers were studied. Results show that the combined anions greatly influence the solubility and thermal stability of the polymers. Among these polymers, poly-alkylimidazolium bis(trifluoromethyl sulfonyl)imide polymers exhibited the highest thermal stability (> 400°), which makes them candidates for many applications. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics