Month: December 2022

Oxaziridine-mediated intramolecular amination of sp³-hybridized C-H bonds was written by Allen, Charles P.;Benkovics, Tamas;Turek, Amanda K.;Yoon, Tehshik P.. And the article was included in Journal of the American Chemical Society in 2009.SDS of cas: 1186603-47-3 The following contents are mentioned in the article:

We describe a new oxaziridine-mediated approach to the amination of sp³-hybridized C-H bonds. In the presence of a copper(II) catalyst, N-sulfonyl oxaziridines participate in efficient intramol. cyclization reactions to afford a variety of piperidine and tetrahydroisoquinoline structures, e.g. I and II. The aminal intermediates provide a convenient functional handle for further elaboration of these structures, demonstrating the utility of this new methodol. for the rapid construction of structurally complex nitrogen-containing heterocycles. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3SDS of cas: 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.SDS of cas: 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Design, Synthesis and Cytotoxic Activities of Pyrazole-Perimidine Hybrids was written by Guemues, Mehmet;Guemues, Nisa;Eroglu, Halil Erhan;Koca, Irfan. And the article was included in ChemistrySelect in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Nine perimidine-pyrazole hybrids I [R = H, Me, Cl; Ar = Ph, 4-MeC₆H₄, 2-MeOC₆H₄, 4-FC₆H₄, 4-BrC₆H₄] were designed and synthesized. Genotoxic, mutagenic and carcinogenic effects of two of the synthesized compounds I [R = H, Ar = 4-MeC₆H₄; R = Me, Ar = 4-BrC₆H₄] were evaluated. The tested compounds could cause chromosomal damage by genotoxic potential and mitotic delay by cytotoxic potential at high concentrations (25-100μM). This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cascade bicyclizations of o-alkynyl aldehydes with thiazolium salts: a new access toward poly-functionalized indeno[2,1-b]pyrroles was written by Zhou, Peng;Hao, Wen-Juan;Zhang, Jin-Peng;Jiang, Bo;Li, Guigen;Tu, Shu-Jiang. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Computed Properties of C15H9ClO The following contents are mentioned in the article:

A new cascade bicyclization of o-alkynyl aldehydes with thiazolium salts is described, in which 25 examples of densely functionalized indeno[2,1-b]pyrroles I (Z = CH, N; R = Et, Me, Bn; R¹ = H, 6-F, 6-Cl, 5-F; Ar = Ph, 4-MePh, 4-OMePh, 4-FPh, 4-ClPh, etc.) are achieved in a functional-group-compatible manner. Thiazole carbenes generated in situ from thiazolium salts play dual roles as reaction partners and as NHC catalysts. The synthetic utility of these bicyclization reactions results in subsequent C-C bond-forming events to rapidly build up mol. complexity. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Computed Properties of C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Silver Nitrate Mediated Cyclization/N-N Bond-Cleavage Reaction for the Synthesis of 3-Arylisoquinolines was written by Zhao, Yun-Hui;Li, Yubo;Luo, Mingjian;Tang, Zilong;Deng, Keqin. And the article was included in Synlett in 2016.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

An unprecedented silver nitrate mediated novel transformation of aromatic hydrazones (R¹)(2-H₂NN=C)C₆H₃CCR² (R¹ = H, 4-Cl, 5-F, 4-Me, 4-MeO; R² = C₆H₅, 4-ClC₆H₄, 4-H₃COC₆H₄, etc.) into various isoquinolines I (X = H, 6-F, 7-Cl, 7-Me, 7-MeO) has been developed. This method involves a silver nitrate promoted cyclization of aromatic hydrazones followed by N-N bond cleavage, and has wide substrate scope under mild conditions. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Name: 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Name: 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Metal-/solvent-free oxidative [4 + 2]/[3 + 2] annulation of 2-ethynylbenzaldehydes with arylalkenes: facile synthesis of benzo[a]fluoren-5-ones was written by Wang, Cheng-Yong;Yu, Jiang-Xi;Liu, Bang;Zhang, Fu-Xing;Wang, Zhi-Qiang;Hu, Qin-Yu;Xu, Zhi-Feng;Li, Jin-Heng. And the article was included in Organic Chemistry Frontiers in 2022.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

A DTBP-mediated oxidative [4 + 2]/[3 + 2] annulation was reported between 2-alkynylbenzaldehydes and terminal arylalkenes enabled by aldehyde C(sp2)-H functionalization for assembling a range of benzo[a]fluoren-5-ones, e.g., I, with high step-economy, simple operation under metal-/solvent-free conditions and excellent functional group tolerance. This method was initiated from 2-alkynylbenzaldehyde reaction partners and provides a useful new strategy to construct complex benzo[a]fluoren-5-one scaffolds compared to existing protocols initiating from alkene reaction partners. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ti(IV) doping: An effective strategy to boost Lewis acidic performance of ZnO catalyst in fluorescein dye synthesis was written by Jadhav, Nirajkumar H.;Shinde, Dnyaneshwar R.;Sakate, Sachin S.;Rasal, Nishant K.;Pawar, Ramdas A.. And the article was included in Catalysis Communications in 2019.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

Zn_1-xTi_xO NPs were efficiently synthesized using a simple solution free mechanochem. method. The synthesized ZnO and Ti(IV)-doped ZnO catalysts are exhibited polycrystallinity, a hexagonal crystal structure, and roughly spherical agglomerates. The surface areas of the Zn_1-xTi_xO catalysts were pos. correlated with the doping percentage of Ti(IV), which also enhanced the Lewis acidity of the NPs. The catalysts exhibited excellent activity during the synthesis of fluorescein dyes. This methodol. was also extended to sulfone-fluorescein dye synthesis. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Tunable Synthesis of Indeno[1,2-c]furans and 3-Benzoylindenones via FeCl₃-Catalyzed Carbene/Alkyne Metathesis Reaction of o-Alkynylbenzoyl Diazoacetates was written by Li, Bin;Shen, Nana;Yang, Yujie;Zhang, Xinying;Fan, Xuesen. And the article was included in Organic Letters in 2021.Application of 1186603-47-3 The following contents are mentioned in the article:

An efficient synthesis of indeno[1,2-c]furan and 3-benzoylindenone derivatives through a FeCl₃-catalyzed carbene/alkyne metathesis reaction of o-alkynylbenzoyl diazoacetates is presented. Mechanistically, the key intermediate, vinyl iron carbene, is formed by 5-exo-dig carbocyclization and terminated with a formal [3 + 2] cycloaddition or carbonylation. To the best of knowledge, this is the first example in which FeCl₃ is used as a catalyst for a carbene/alkyne metathesis reaction. Finally, derivatization reactions were carried out to showcase the value of the products. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An asymmetric synthesis of clopidogrel hydrogen sulfate was written by Sashikanth, Suthrapu;Raju, Veeramalla;Somaiah, Sripathi;Rao, Peddi Srinivasa;Reddy, Karnati Venugopal. And the article was included in Synthesis in 2013.Electric Literature of C9H10ClNO2 The following contents are mentioned in the article:

An asym. synthesis of (S)-(+)-clopidogrel hydrogen sulfate was developed through application of a Strecker reaction with [(1S)-1-(4-methoxyphenyl)ethyl]amine.HCl (I) as a chiral auxiliary. Addition of 2-ClC₆H₄CHO to a solution of NaCN and I gave diastereoisomerically pure (2S)-(2-chlorophenyl){[(1S)-1-(4-methoxyphenyl)ethyl]amino}acetonitrile.HCl. Cleavage of the chiral auxiliary and concomitant hydrolysis of the nitrile group then gave enantiomerically pure (2S)-2-(2-chlorophenyl)glycine.HCl, a key intermediate for (S)-(+)-clopidogrel. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Electric Literature of C9H10ClNO2).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Electric Literature of C9H10ClNO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Green Synthesis of 3-Substituted-4-arylmethylideneisoxazol-5(4H)-one Derivatives Catalyzed by Salicylic Acid was written by Mosallanezhad, Asiyeh;Kiyani, Hamzeh. And the article was included in Current Organocatalysis in 2019.Quality Control of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

The efficient and environmental friendliness procedure for the synthesis of isoxazol-5(4H)-ones was introduced. Salicylic acid was used as an inexpensive, easy to handle and safe catalyst for the synthesis of title compounds 3-Substituted-4-arylmethylideneisoxazol-5(4H)-ones were obtained from readily available aryl/heteroaryl aldehydes and β-keto esters via the cyclocondensation reaction without using thermal, microwave or ultrasound conditions. It must be highlighted that the procedure is operationally mild and simple, and the desired small heterocycles were obtained in good to high yields. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Quality Control of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Quality Control of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, spectral and biological studies of some s-triazine derivatives of 1-(1-(4methoxyphenyl)ethyl)cyclohexanol was written by Sudani, Bhadreshkumar R.;Desai, Vikas A.. And the article was included in World Journal of Pharmaceutical Research in 2017.SDS of cas: 2272-40-4 The following contents are mentioned in the article:

With the help of some new synthetic protocols a series of s-triazine derivatives of 1-(1-(4- methoxyphenyl)ethyl)cyclohexanol I (R¹ = Et, Ph, 4-ClC₆H₄, 2-ClC₆H₄, 2-O₂NC₆H₄; R² = 2-FC₆H₄, 3,4-F₂C₆H₃) is prepared Antibacterial and antifungal activities were evaluated for the selected synthesized derivatives Some of the compounds were found good activity against different Gram pos., Gram neg. bacterial strains and fungal stains. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4SDS of cas: 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics