Month: December 2022

Pd(II)-Catalyzed Carbonyl-Directing Activation of Alkenes: Selective Fluorosulfonylation and Aminosulfonylation of 1,7-Enynes was written by Zhu, Yi-Long;Zhu, Chi-Fan;Zhou, Peng;Hao, Wen-Juan;Wang, De-Cai;Tu, Shu-Jiang;Jiang, Bo. And the article was included in Journal of Organic Chemistry in 2018.Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

A new Pd(II)-catalyzed carbonyl-directing activation of alkenes has been established, enabling radical-induced selective fluorosulfonylation and aminosulfonylation of carbonyl-tethered 1,7-enynes with sulfinic acids and N-fluorobenzenesulfonimide (NFSI) under mild and redox neutral conditions to access densely functionalized (E)-3,4-dihydronaphthalen-1(2H)-ones with generally good yields and high stereoselectivity. The selectivity of these bifunctionalizations relies on the electronic nature of substituents on both aryl rings of 1,7-enynes. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Safety of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chitosan-Based Magnetic Polymetallic Pd-Catalysts for Heck Reaction in Aqueous Media was written by Bumagin, N. A.. And the article was included in Russian Journal of General Chemistry in 2022.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

A mechanochem. method was developed for the synthesis of ferromagnetic Pd-Fe-Co-Ni composites based on the natural biopolymer chitosan, which are highly efficient catalysts for the Heck reaction for the synthesis of aryl alkenes (E)-ArCH=CHR (R = C(O)₂H, C(O)₂n-Bu; Ar = 4-OHC₆H₄, 4-O₂NC₆H₄, 4-CH₃OC₆H₄, etc.) in aqueous media in the presence of an ionic liquid and can be readily extracted with an external magnet for reuse in catalysis. This study involved multiple reactions and reactants, such as Sodium tetrachloropalladate(II) (cas: 13820-53-6Category: chlorides-buliding-blocks).

Sodium tetrachloropalladate(II) (cas: 13820-53-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Oxidation of alcohols to aldehydes and ketones using selenium ionic liquid was written by Cheng, Xian Yi;Li, Kang Feng;Wang, Qiao Jian;Wang, Cong Ying;Ying, Tao Kai. And the article was included in Chinese Chemical Letters in 2012.Application of 6294-17-3 The following contents are mentioned in the article:

A new type of ionic liquid supported selenium reagents was synthesized and was found to be an excellent catalyst in the oxidation of alcs. to aldehydes and ketones in the presence of 30% H₂O₂. The predictable solubility of ionic liquids allows an easy separation of the oxidation products from the reaction mixture Furthermore, the oxidation can be carried out using an ionic liquid as the solvent, and the ionic liquid-supported selenium reagents can be recycled and used 4 times with little decrease in catalytic performance. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of (αS)-α-amino-2-chlorobenzeneacetic acid methyl ester was written by Ding, Gui-li;Zhao, Min;Wu, Fan-hong;Yu, De-fei;Chen, Jian-zhon. And the article was included in Guangzhou Huagong in 2007.Product Details of 141109-14-0 The following contents are mentioned in the article:

A method for the synthesis of the title compound and a resolution method are reported here. L-(+)-tartaric acid was used as resolving agent. Optimum resolution process conditions were: 30°, 5 h, a mixture of acetone and methanol solvent volume ratio 1:4 and the mol ratio of α-amino-2-chlorobenzeneacetic acid Me ester to L-(+)-tartaric 1:1.1. The resolution process provide a yield above 90% (optical rotation 88°). This process may have industrial applications. The above-mentioned title compound is an intermediate in the synthesis of clopidogrel. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Product Details of 141109-14-0).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 141109-14-0

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Utilization of cyanuric chloride in the synthesis of some novel chalcones and their derivatives was written by Kapadia, Kishor;Solankee, Pankit;Prajapati, Yogesh;Patel, Hiral;Solankee, Sejal;Solankee, Anjani. And the article was included in Organic Chemistry: An Indian Journal in 2007.Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Base catalyzed condensation of 2,4-bis-(phenylamino)-6-(4′-acetyl phenylamino)-5-triazine with different aromatic aldehydes yield chalcones. These chalcones on cyclization with hydrazine hydrate in presence of glacial acetic acid and malononitrile in presence of ammonium acetate give the corresponding acetylpyrazolines, e.g., I, and cyanopyridines, e.g., II, resp. The constitutions of newly synthesized compounds have been established on the basis of their elemental anal., IR and ¹H NMR spectral data. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Optically active S-triazine: preparation of α-(2-anilino-4-amino-S-triazin-6-ylamino)-β-thiolpropionic acid was written by Watanabe, Nobuo;Mitsumoto, Isao;Kato, Tadashi;Usami, Takashi. And the article was included in Tokyo Kogyo Koto Senmon Gakko Kenkyu Hokokusho in 1979.COA of Formula: C9H6Cl2N4 The following contents are mentioned in the article:

The title triazine derivative I [R = NH₂, R¹ = NHCH(CH₂SH)CO₂H] was prepared by amination of cyanuric chloride with aniline in acetone at 0-5° to give 96.7% I (R = R¹ = Cl)(II), amination of II with L-(-)-cysteine in acetone at 40-50° to give 86.2% I [R = Cl, R¹ = NHCH(CH₂SH)CO₂H], followed by amination with NH₄OH 2 h at 80-90°(in 83.3% yield). This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4COA of Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.COA of Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Practical regioselective halogenation of vinylogous esters: synthesis of differentiated mono-haloresorcinols and polyhalogenated resorcinols was written by Chen, Xiaohong;Liu, Xiaoguang;Martinez, Jenny S.;Mohr, Justin T.. And the article was included in Tetrahedron in 2016.Safety of 4-Chlororesorcinol The following contents are mentioned in the article:

A practical and efficient method for the direct, regioselective conversion of vinylogous esters to haloresorcinols is reported. Control of the reaction conditions enables synthesis of either the 4- or 6-haloresorcinol isomers from a common precursor with excellent regiocontrol and high yield. The generality and functional group tolerance of this novel protocol is demonstrated. The utility of this methodol. to access polyhaloresorcinols is also reported. These methods create useful functionalized building blocks for further synthetic applications. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Safety of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

An efficient, “green” approach to aryl amination of cyanuric chloride using acetic acid as solvent was written by Kolmakov, Kirill A.. And the article was included in Journal of Heterocyclic Chemistry in 2008.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Acetic acid is an inexpensive and environmentally friendly solvent for facile, clean and high-yielding aryl amination of cyanuric chloride with aromatic amines, including nitroanilines. Aryl amination in acetic acid medium and isolation protocol are greatly simplified as compared to previously reported procedures. Under proper conditions, it is possible to attach the same or different aniline residues in a controlled way to obtain in excellent yields sym. and unsym. 1,3,5-triazine derivatives, e.g. I and II, resp. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Category: chlorides-buliding-blocks).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Coumarin as a Surrogate for the Protection-group-free Synthesis of o-Hydroxy Stilbenes: Hydrolysis-Decarboxylation-Heck Coupling Reactions in One Pot was written by Andhare, Nitin H.;Equbal, Danish;Sinha, Arun K.. And the article was included in Chemistry – An Asian Journal in 2022.Safety of Lithium chloride The following contents are mentioned in the article:

Here, a successful attempt is made to develop a one-pot protocol for the synthesis of 2-hydroxystilbene derivatives I (R = Ph, naphthalen-2-yl, thiophen-2-yl, benzo[d][1,3]dioxol-5-yl, etc.; R¹ = H, Me) via hydrolysis of natural coumarins II followed by in situ decarboxylative Heck coupling with haloarenes RX (X = I, Br). Fine tuning of the reaction conditions allowed exclusive formation of 2-hydroxystyrylbenzenes I over other possible side products, i.e., benzofuran/substituted coumarins. This study involved multiple reactions and reactants, such as Lithium chloride (cas: 7447-41-8Safety of Lithium chloride).

Lithium chloride (cas: 7447-41-8) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of Lithium chloride

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Silver/Rhodium Relay Catalysis Enables C-H Functionalization of In Situ Generated Isoquinolines with Sulfoxonium Ylides: Construction of Hexahydrodibenzo[a,g]quinolizine Scaffolds was written by Li, Quanzhe;Liu, Ruixing;Wei, Yin;Shi, Min. And the article was included in Advanced Synthesis & Catalysis in 2021.Related Products of 1186603-47-3 The following contents are mentioned in the article:

Employing silver/rhodium relay catalysis strategy, an intramol. electrophilic cyclization and C-H activation followed by cascade hydrogenation and reductive amination has been developed. The acylmethylated isoquinoline derivatives could be afforded with broad substrate scope in 23-88% yields, which could be further transformed to the core skeleton of hexahydrodibenzo[a,g]quinolizine as drug-candidates. Moreover, this reaction was achieved in a gram-scale. A reasonable reaction mechanism has been proposed based on a series of control and KIE experiments This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Related Products of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics