Month: December 2022

Construction of benzothiophene fused pyrrolidone in water via a catalyst-free process and a mechanism study was written by Shen, Jinhui;Yu, Aimin;Zhang, Lei;Meng, Xiangtai. And the article was included in Green Chemistry in 2020.Synthetic Route of C6H9ClO3 The following contents are mentioned in the article:

A novel three-component domino reaction toward benzothiophene fused pyrrolidone derivatives I [R¹ = H, 5-Br, 5-OMe, etc.; R² = n-Bu, cyclopentyl, Bn, etc.] was developed in an environmentally benign manner. The reaction proceeded well in aqueous media, and delivered the desired products I in high yields with excellent selectivity. D. functional calculations located a multi-step reaction pathway and identified the intramol. nucleophilic addition step to be the rate-determining step. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Synthetic Route of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Synthetic Route of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ionic liquid modified carbon nanotube supported palladium nanoparticles for efficient Sonogashira-Hagihara reaction was written by Gholinejad, Mohammad;Esmailoghli, Hamid;Khosravi, Faezeh;Sansano, Jose M.. And the article was included in Journal of Organometallic Chemistry in 2022.Application of 13820-53-6 The following contents are mentioned in the article:

A palladium supported onto an ionic liquid-modified carbon nanotube was prepared SEM, energy dispersive spectroscopy, thermogravimetric anal., transmission electron microscopy and XPS were used to complete its characterization. The application as catalyst in the copper-free Sonogashira-Hagihara coupling was also studied employing different substrates. This heterogeneous catalyst was successfully recycled for 5 consecutive identical reactions maintaining its efficiency. After this fifth catalytic run the catalyst was characterized again. This study involved multiple reactions and reactants, such as Sodium tetrachloropalladate(II) (cas: 13820-53-6Application of 13820-53-6).

Sodium tetrachloropalladate(II) (cas: 13820-53-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Application of 13820-53-6

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Enantioselective Synthesis of Isoquinolines: Merging Chiral-Phosphine and Gold Catalysis was written by Gao, Yu-Ning;Shi, Feng-Chen;Xu, Qin;Shi, Min. And the article was included in Chemistry – A European Journal in 2016.Formula: C15H9ClO The following contents are mentioned in the article:

The highly enantioselective synthesis of dihydroisoquinoline derivatives from aromatic sulfonated imines tethered with an alkyne moiety, through a one-pot asym. relay catalysis of chiral-phosphine and gold catalysts, is reported. Enantiomerically enriched dihydroisoquinoline derivatives were afforded in good yields and good-to-excellent ee values under mild conditions, based on the asym. aza-Morita-Baylis-Hillman reaction. Dihydroisoquinoline derivatives containing two chiral centers were also synthesized through further transformations. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Formula: C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Formula: C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-Catalyzed C-S Reductive Cross-Coupling of Alkyl Halides with Arylthiosilanes toward Alkyl Aryl Thioethers was written by Yang, Yu-Zhong;Li, Yang;Lv, Gui-Fen;He, De-Liang;Li, Jin-Heng. And the article was included in Organic Letters in 2022.Recommanded Product: 6294-17-3 The following contents are mentioned in the article:

A nickel-catalyzed C-S reductive cross-coupling of alkyl halides with arylthiosilanes for producing alkyl aryl thioethers is developed. This reaction is initiated by umpolung transformations of arylthiosilanes followed by C-S reductive cross-coupling with alkyl halides to manage an electrophilic alkyl group onto the electrophilic sulfur atom and then construct a C(sp3)-S bond, and features exquisite chemoselectivity, excellent tolerance of diverse functional groups, and wide applications for late-stage modification of biol. relevant mols. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Excited-state palladium-catalysed reductive alkylation of imines: scope and mechanism was written by Kancherla, Rajesh;Muralirajan, Krishnamoorthy;Rueping, Magnus. And the article was included in Chemical Science in 2022.Reference of 6294-17-3 The following contents are mentioned in the article:

The development of excited-state palladium-catalyzed reductive alkylation of imines with alkyl bromides was described. The new methodol. showed broad functional group tolerance and was addnl. be applied in the direct three-component reaction of aldehydes, anilines and alkyl bromides to give the alkyl amines under mild reaction conditions. Time-resolved photoluminescence experiments allowed the determination of the excited-state reaction kinetics and indicate that the reaction was proceeded via the inner-sphere electron transfer mechanism. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Reference of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

s-Triazine derivatives and their microbial activity: Part-1 was written by Patel, R. P.;Chaudhari, J. A.;Hathi, M. V.. And the article was included in Oriental Journal of Chemistry in 2007.Formula: C9H6Cl2N4 The following contents are mentioned in the article:

Various 2-phenylamino-4,6-diphenylhydrazino-1,3,5-triazines I (Ar = Ph, ClC₆H₄, BrC₆H₄, MeC₆H₄, MeOC₆H₄, Me₂CHC₆H₄) were prepared by reaction of 2-phenylamino-4,6-dichloro-1,3,5-triazine and various phenylhydrazine derivatives I were characterized by elemental anal. and IR spectral studies. I were screened for microbial activity against Gram-pos. and Gram-neg. bacteria. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Formula: C9H6Cl2N4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C9H6Cl2N4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Preparation of s-triazine-Δ²-pyrazolines. I. 3,5-diphenyl-Δ²-pyrazoline reaction with chloro-s-triazines was written by Prejmereanu, Ioan;Sebe, Ion;Floru, Lucian. And the article was included in Revistade Chimie (Bucharest, Romania) in 1994.Application of 2272-40-4 The following contents are mentioned in the article:

3,5-Diphenyl-Δ²-pyrazoline (I) acylation reaction with cyanuric chloride or its mono- or di-substituted derivatives was studied, with respect to the nucleophilic reagent, acylation agent, , catalyst presence, temperature, and reaction solvent in preparation of the title compounds II (X, Y = Cl, R²R¹N, RO wherein R, R¹, R² = H, alkyl, aryl). Cyanuric chloride was reacted with I at 5° for 30 min to give II (X = Y = Cl). This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides was written by Verma, Piyush Kumar;Prasad, K. Sujit;Varghese, Dominic;Geetharani, K.. And the article was included in Organic Letters in 2020.Reference of 6294-17-3 The following contents are mentioned in the article:

A Co-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B₂pin₂ or B₂neop₂) was developed under mild reaction conditions, demonstrating the 1st Co-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this Co-mediated catalytic cycle. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Reference of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Targeting the hydrophobic region of Hsp90’s ATP binding pocket with novel 1,3,5-triazines was written by Lee, Taeho;Seo, Young Ho. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Application of 2272-40-4 The following contents are mentioned in the article:

Heat shock protein 90 (Hsp90) is a mol. chaperone that plays an important role in regulating the maturation and stabilization of many oncogenic proteins. In an attempt to discover a new class of Hsp90 inhibitors, a series of 1,3,5-triazine compounds were rationally designed, synthesized, and their biol. activities were evaluated. Compound 3b was found to degrade Hsp90’s client proteins of Her2, Met and Akt and to induce the expression level of Hsp70. The binding mode of 3b in the ATP-binding site of Hsp90 was predicted by the mol. docking. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Application of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Application of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

NHC-Catalyzed oxidative cyclization reactions of 2-alkynylbenzaldehydes under aerobic conditions: synthesis of O-heterocycles was written by Park, Jong Hyub;Bhilare, Sachin V.;Youn, So Won. And the article was included in Organic Letters in 2011.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde The following contents are mentioned in the article:

An NHC-catalyzed, regio- and stereoselective oxidative cyclization of o-alkynylbenzaldehydes bearing an unactivated alkyne moiety as an internal electrophile has been developed to afford phthalides and isocoumarins. A single organocatalytic system enabled two sequential C-O bond formations to take place in an atom economical manner via highly efficient dual activation. Mol. oxygen in air could be utilized as a source of an oxygen atom for the oxidation of aldehydes to the corresponding benzoic acids under our newly developed reagent system. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Application In Synthesis of 5-Chloro-2-(phenylethynyl)benzaldehyde

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics