Month: December 2022

Catalyst and additive free 6-endo-dig cyclization of ortho-alkynylarylaldimines in water: An environmentally friendly access to isoquinolines was written by Yang, Jin;Wei, Xinyu;Yu, Yajun;Zhu, Yeting;Zhao, Yun-Hui;Xie, Wenlin;Zhao, Lang. And the article was included in Tetrahedron Letters in 2020.Related Products of 1186603-47-3 The following contents are mentioned in the article:

A novel and sustainable route for the synthesis of isoquinolines I (R¹ = 7-OCH₃, 7-Me, 7-Cl, 6-F; R² = 4-methoxyphenyl, 3-chlorophenyl, Bu, etc.) was developed by reacting 2-ethynylbenzaldehydes 2-R²CC-R³C₆H₃CHO (R³ = 5-MeO, 5-Me, 5-Cl, H, 4-F) with ammonium hydroxide in water. This method provides a convenient, atom-economical, and catalyst-free access to diversely substituted isoquinolines with moderate to good yields. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Related Products of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Related Products of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis and study of anisotropic ammonium salts for production of liquid-crystalline materials and devices with variable surface anchoring was written by Kuz’menok, N. M.;Mikhalyonok, S. G.;Arol, A. S.;Bezborodov, V. S.;Krakhalev, M. N.;Sutormin, V. S.;Prishchepa, O. O.;Zyryano, V. Ya.. And the article was included in Zhidkie Kristally i Ikh Prakticheskoe Ispol’zovanie in 2018.Related Products of 122-18-9 The following contents are mentioned in the article:

This paper describes the various anisotropic quaternary ammonium salts characterized by a specific interaction with the interface and capable to form various orientational structures of liquid crystal layer, have been prepared It has been shown that these salts are promising materials for creation of advanced liquid crystal compositions with surface anchoring caused by ionic surfactants. The obtained results are of undoubted interest for the developers of new liquid crystal materials and electro-optical devices based on them. This study involved multiple reactions and reactants, such as N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9Related Products of 122-18-9).

N-Benzyl-N,N-dimethylhexadecan-1-aminium chloride (cas: 122-18-9) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Related Products of 122-18-9

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids as potential antimalarial agents was written by Manohar, Sunny;Khan, Shabane I.;Rawat, Diwan S.. And the article was included in Chemical Biology & Drug Design in 2011.Related Products of 2272-40-4 The following contents are mentioned in the article:

The authors report the synthesis of a series of 4-aminoquinoline-1,2,3-triazole and 4-aminoquinoline-1,2,3-triazole-1,3,5-triazine hybrids and evaluation of their antimalarial activity against D6 and W2 strains of Plasmodium falciparum. To study the structure-activity relationship of substituted 4-aminoquinoline-based hybrids, 34 structurally diverse compounds were synthesized and tested against D6 and W2 strains of P. falciparum. Some of the compounds showed promising antimalarial activity without toxicity against Vero cells. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Related Products of 2272-40-4).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Related Products of 2272-40-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Reaction of cyanuric chloride and its derivatives with polyamide fibers in non-aqueous medium was written by Hanna, H. L.;Abd El-Thalouth, I.;Hebeish, A.. And the article was included in Angewandte Makromolekulare Chemie in 1978.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Cyanuric chloride [108-77-0] did not react with polyamide fibers in non-aqueous medium but became phys. adhered to the fiber. Increasing the concentration of cyanuric chloride caused a substantial increase in the amount of extra N content of the fiber. Greater adsorption occurred in xylene than in tetrachloroethylene but a 1:3 mixture of tetrachloroethylene and xylene gave the best results. Chem. reaction was achieved by use of 2-anilino-4,6-dichloro-1,3,5-triazine [2272-40-4] and disperse dyes containing chlorotriazine rings. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Safety of 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Base-Catalyzed Cyclization of 1,6-Diynyl Carboxylates Involving Propargyl-Allenyl Isomerization: Efficient Synthesis of Benzo[b]fluorene and Its Analogues was written by Sun, Ning;Xie, Xin;Wang, Gaonan;Chen, Haoyi;Liu, Yuanhong. And the article was included in Advanced Synthesis & Catalysis in 2017.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

An efficient protocol for the synthesis of benzo[b]fluorenes via base-catalyzed cyclization of 1,6-diynyl carbonates, esters or ethers was developed. The reaction likely proceeded via base-induced propargyl-allenyl isomerization followed by Schmittel-type cyclization. Heterocycle-fused fluorenes such as thiophene- or pyridine-fused substrates could also be conveniently constructed by this method. The synthetic utility of this reaction was demonstrated by the preparation of up to seven-ring fused polycyclic aromatic hydrocarbons. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Category: chlorides-buliding-blocks).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic Base-Mediated Carboxylation of (Hetero)aromatic Compounds Using Supercritical Carbon Dioxide (scCO₂) was written by Chetty, Lloyd C.;Kruger, Hendrik G.;Arvidsson, Per I.;Naicker, Tricia;Govender, Thavendran. And the article was included in Synthesis in 2022.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

A straightforward site-selective method for the direct carboxylation of resorcinols (3-hydroxyphenol derivatives), phenols ROH (R = Ph, 3-hydroxyphenyl, 2-methyl-3-hydroxyphenyl, etc.), and indoles I (R¹ = H, Br, nitro) is reported. The products were obtained in moderate to high yields using supercritical carbon dioxide as an electrophile and solvent under basic conditions. This method offers solvent and metal free conditions without the cumbersome exclusion of air or water with convenient purification This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Catalyst and Sensitizer-Free Visible-Light-Induced C(sp²)-H Chalcogenation of Arenes/Heteroarenes with Dichalcogenides was written by Kumaraswamy, Gullapalli;Ramesh, Vankudoth;Gangadhar, Maram;Vijaykumar, Swargam. And the article was included in Asian Journal of Organic Chemistry in 2018.Application In Synthesis of 4-Chlororesorcinol The following contents are mentioned in the article:

A direct selenation of arenes and heteroarenes at room temperature has been accomplished. This protocol was enabled by a visible-light-promoted single-electron-transfer (SET) pathway without a directing group. An array of arenes and heteroarenes, such as indoles, pyrroles, and functionalized aryl substrates could go through this selenation with high yields and regioselectivity. The salient feature of this protocol is the SET achieved by irradiating one of two organic mols. thereby avoiding a sensitizer to form a radical ion pair. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Application In Synthesis of 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Application In Synthesis of 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis, characterization and anti-microbial activity of novel pyrimidine derivatives was written by Kumar, Konda Ravi;Sumanjali, K. N. S. Sneha;Chandana, M. Priya;Srilatha, N.;Rao, P. Koteswara. And the article was included in Journal of Drug Delivery and Therapeutics in 2021.Quality Control of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Chalcones reacted with aminoguanidine to give intermediate compounds which on further reacted with substituted ketones to give pyrimidine derivatives A total of 6 compounds were synthesized from one scheme and they were recrystallized by appropriate solvents. They were identified and characterized by various spectral methods. In the present study, all synthesized compounds tested for antibacterial activity and anti-fungal activity. They showed significant activity when compared with standard drug Streptomycin and Miconazole resp. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Quality Control of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Quality Control of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Regioselective Halogenation of 2H-Chromenones Promoted by Oxone and NaX: A Facile Approach for the Preparation of Halochromenones and 2H-Chromenone Natural Products was written by Vanammoole, Lakshmireddy;Kommera, Rajkumar;Hariprasad Kurma, Siva;Rao Vaidya, Jayathirtha;Raju Bhimapaka, China. And the article was included in ChemistrySelect in 2020.COA of Formula: C6H9ClO3 The following contents are mentioned in the article:

A systematic study was conducted for the regioselective halogenation of 2H-chromenones to prepare 3-halo-2H-chromenones, 4-substituted 3-halo-2H-chromenones and 3-(2-haloacetyl)-2H-chromenones. Com. available NaCl/NaBr was used as halogen source and oxone as an oxidant to produce the compounds Further, the method was successfully applied for the preparation of pharmaceutically important halogenated 2H-chromenone natural products. The present approach was simple, economically viable and provided the target compounds with good yields. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3COA of Formula: C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Solvent-Regulated Coupling of 2-Alkynylbenzaldehydes with Cyclic Amines: Selective Synthesis of Fused N-Heterocycles and Functionalized Naphthalene Derivatives was written by He, Yan;Zheng, Zhi;Liu, Qimeng;Zhang, Xinying;Fan, Xuesen. And the article was included in Organic Letters in 2020.Formula: C15H9ClO The following contents are mentioned in the article:

An efficient synthesis of 1,2,3,4-tetrahydrobenzo[g]quinoline derivatives through PdCl₂-catalyzed, TBHP-promoted, and toluene-mediated dehydrogenation/[4+2] cycloaddition of saturated cyclic amines with 2-alkynylbenzaldehydes was developed. On the contrary, when the reaction medium was changed from toluene to DMSO/H₂O, another class of important compounds, naphthyl chain amines, formed via a dehydrogenation-intermol. condensation-C-N bond cleavage-intramol. condensation pathway, was obtained with good selectivity. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Formula: C15H9ClO).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Formula: C15H9ClO

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics