Month: December 2022

Zaitsev, O. I. published the artcileQuantitative determination of decamethoxin in the medicinal substance Decaceol, Synthetic Route of 38146-42-8, the publication is Medichna Khimiya (2003), 5(1), 103-105, database is CAplus.

The requirements for detection of decamethoxin in type NaA zeolite by means of gas chromatog. are provided. The decamethoxin concentration equal to 0.100 ± 0.005% was determined It is established that the requirements for gas chromatog. of decamethoxin can be used for its determination in Decaceol.

Medichna Khimiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C9H9ClN2, Synthetic Route of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gollner, Andreas published the artcileTwo-Step Total Syntheses of Canthin-6-one Alkaloids: New One-Pot Sequential Pd-Catalyzed Suzuki-Miyaura Coupling and Cu-Catalyzed Amidation Reaction, SDS of cas: 145349-62-8, the publication is Organic Letters (2010), 12(6), 1352-1355, database is CAplus and MEDLINE.

Canthin-6-one (I; R¹ = R² = H) and nine analogs including the naturally occurring 9-methoxycanthin-6-one (I; R¹ = OMe, R² = H) and amaroridine (I; R¹ = H, R² = OMe) are prepared rapidly and in high yields via a convergent “non-classical” strategy that focuses on construction of the central ring B. The strategy relies on concomitant Pd-catalyzed Suzuki-Miyaura C-C coupling followed by a Cu-catalyzed C-N coupling that can be achieved either stepwise or in a new one-pot protocol starting from the appropriate 8-bromo-1,5-naphthyridine.

Organic Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, SDS of cas: 145349-62-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Broumidis, Emmanouil published the artcileA one-pot, two-step synthesis of 3-deazacanthin-4-ones via sequential Pd-catalyzed Suzuki-Miyaura and Cu-catalyzed Buchwald-Hartwig reactions, Category: chlorides-buliding-blocks, the publication is Tetrahedron Letters (2017), 58(27), 2661-2664, database is CAplus.

3-Deazacanthin-4-one and nine analogs, including the 8-aza analog, were prepared rapidly and in high yields from 8-iodoquinolones and 2-chloro(het)arylboronic acids. The strategy involves construction of the central B ring via sequential Pd-catalyzed Suzuki-Miyaura C-C and Cu-catalyzed Buchwald-Hartwig C-N coupling reactions [e.g., Suzuki reaction of iodoquinolone I with (2-chlorophenyl)boronic acid followed by intramol. Buchwald-Hartwig → II (90%)].

Tetrahedron Letters published new progress about 145349-62-8. 145349-62-8 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids, name is 2-Chloro-4-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Zhang, Hui published the artcileAltering intercomponent interactions in a photochromic multi-state [2]rotaxane, Quality Control of 219537-97-0, the publication is Organic & Biomolecular Chemistry (2011), 9(11), 4051-4056, database is CAplus and MEDLINE.

Rotaxanes have attracted much attention because of their challenging constructions and potential applications. In this paper, a multi-state [2]rotaxane, in which a dithienylethene-functionalized dibenzo-24-crown-8 macrocycle was interlocked onto a thread component bearing a 4-morpholin-naphthalimide fluorescent stopper and two distinct recognition sites, namely, dibenzylammonium and N-methyltriazolium recognition sites, was prepared and studied. By introducing a dithienylethene photochrome into the macrocycle component, multi-mode alteration of the intercomponent interactions, such as energy transfer, electron transfer, and charge transfer interaction between the photochrome and the fluorescent naphthalimide stopper could be altered in this multi-state rotaxane system in response to the combination of chem. and photochem. stimuli.

Organic & Biomolecular Chemistry published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C20H21ClN4O4, Quality Control of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ogris, Manfred published the artcileNovel biocompatible cationic copolymers based on polyaspartylhydrazide being potent as gene vector on tumor cells, COA of Formula: C7H16ClNO2, the publication is Pharmaceutical Research (2007), 24(12), 2213-2222, database is CAplus and MEDLINE.

The reaction between α,β-poly(aspartylhydrazide) (PAHy), a water soluble synthetic polymer and 3-(carboxypropyl)trimethyl-ammonium chloride (CPTACl) produced copolymers bearing permanent pos. charges (PAHy-CPTA) with mol. weight of 10 kDa and PAHy-CPTA copolymers differing in pos. charge amount (18-58%) were chosen for biol. investigations. Biophys. properties of DNA/PAHy-CPTA polyplexes were evaluated in terms of DNA condensation, zeta potential and size distribution. Cytotoxicity studies on Neuro2A murine neuroblastoma cells evidenced absence of toxicity of these copolymers up to 300 μg/mL unlike linear polyethylenimine (LPEI) that was highly toxic already at 20 μg/mL. PAHy-CPTA copolymers did not induce any erythrocyte aggregation up to 1 mg/mL. Cellular interaction studies of PAHy-CPTA polyplexes evidenced a faster binding of these polyplexes with cells compared to DNA/LPEI polyplexes. The in vitro transfection ability of PAHy-CPTA polyplexes was strongly affected by exptl. conditions reaching about 10% of the transfection efficiency of optimized LPEI polyplexes. Finally, in vivo application studies confirmed the biocompatibility of PAHy-CPTA copolymers. With LPEI, clear signs of microvesicular fatty liver were observed and with LPEI polyplexes significant weight loss. In strong contrast, PAHy-CPTA did not induce histopathol. changes or weight loss.

Pharmaceutical Research published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C7H16ClNO2, COA of Formula: C7H16ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Majewski, Piotr published the artcileSynthesis of Dichloromethylphosphonates, SDS of cas: 866-23-9, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2009), 184(4), 956-962, database is CAplus.

Efficient synthesis of O,O-dialkyl, O-alkyl-N,N-dialkylamido and N,N,N’,N’-tetraalkyldiamido dichloromethylphosphonates via treatment of O,O-dialkyl, O-alkyl-N,N-dialkylamido, and N,N,N’,N’-tetraalkyldiamido trichloromethylphosphonates with di-Et phosphite in the presence of triethylamine in ethanol has been described.

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 866-23-9. 866-23-9 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyltrichloromethylphosphonate, and the molecular formula is C5H10Cl3O3P, SDS of cas: 866-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Merchant, Jaysukhlal R. published the artcileSynthesis of sulfones with antitubercular activity, Application of Coumarin-6-sulfonyl chloride, the publication is Chemistry & Industry (London, United Kingdom) (1982), 955, database is CAplus.

6-Coumarylsulfonyl chlorides underwent Friedel-Crafts reaction with aromatic compounds to give 6-coumaryl aryl sulfones in 30-40% yield. E.g., treatment of sulfonyl chloride I (R = Cl) with PhEt for 4 h at 100° in the presence of AlCl₃ gave I (R = C₆H₄Et-p) (II). The sulfones were generally active against Mycobacterium tuberculosis.

Chemistry & Industry (London, United Kingdom) published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Application of Coumarin-6-sulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Takahashi, Hidehiko published the artcileRelation between the hypotensive activity and chemical structure of γ-aminobutyric acid in the rabbit, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, the publication is Japan. J. Physiol. (1962), 97-105, database is CAplus.

γ-Aminobutyric acid applied intrathecalty gave a stronger and longer depressor response than that given intravenously. Me esters and N-substitution of γ-aminobutyric acid gave little response when applied intrathecally.

Japan. J. Physiol. published new progress about 6249-56-5. 6249-56-5 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst,Inhibitor,Natural product, name is 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride, and the molecular formula is C18H19ClN4, Application of 3-Carboxy-N,N,N-trimethylpropan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pashynska, Vlada A. published the artcileOn the stability of the organic dication of the bisquaternary ammonium salt decamethoxinum under liquid secondary ion mass spectrometry, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Rapid Communications in Mass Spectrometry (2005), 19(6), 785-797, database is CAplus and MEDLINE.

In the course of a liquid secondary ion mass spectrometric (SIMS) investigation on a bisquaternary ammonium antimicrobial agent, decamethoxinum, unusual pathways of fragmentation of the organic dication M²⁺ of this bisquaternary salt, with preservation of the doubly charged state of the fragments, were observed To reveal the structural and electronic parameters of decamethoxinum, which are responsible for the stabilization of its organic dication in the gas phase, a comprehensive SIMS study using metastable decay, collision-induced dissociation and kinetic energy release techniques complemented by ab initio quantum chem. calculations was performed. Pathways of fragmentation of two main precursors originating from decamethoxinum – organic dication M²⁺ and its cluster with a Cl^– counterion [M·Cl]⁺ – and a number of their primary fragments were established and systematized. Differences in the pathways of fragmentation of M²⁺ and [M·Cl]⁺ were revealed: the main directions of [M·Cl]⁺ decay involve dequaternization similar to thermal degradation of this compound, while in M²⁺ fragmentation via loss of one and two terminal radicals with preservation of the doubly charged state of the fragments dominates over charge separation processes. It was shown that pairing of the dication with a Cl^– anion does not preserve the complex from fragmentation via separation of two pos. charged centers or neutralization (dequaternization) of one such center. At the same time the low abundance of M²⁺ in the SIMS spectra is to a larger extent controlled by a probability of M²⁺ association with an anion than by the decay of the dication per se. Quantum chem. calculations of the structural and electronic parameters of the decamethoxinum dication have revealed at least three features which can provide stabilization of the doubly charged state. Firstly, in the most energetically favorable stretch conformation the distance between the quaternary nitrogens (r_N1-N2 = 1.39 nm) is relatively large. Secondly, an intramol. solvation of quaternary groups by carbonyl oxygens of the adjacent groups of the dication occurs, which contribute to structural stabilization. Thirdly, an important feature of the electronic structure of the dication is the presence of a partial neg. charge on the nitrogen atoms and smearing of a pos. charge mainly over the hydrogens of alkyl groups attached to the quaternary nitrogens, which reduces the net repulsion between the quaternary groups. The possible influence of charge smearing on the kinetic energy released on the dication fragmentation is discussed.

Rapid Communications in Mass Spectrometry published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Recommanded Product: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sukhodub, L. F. published the artcileMass spectrometry of decamethoxine, an antimicrobial drug, Quality Control of 38146-42-8, the publication is Antibiotiki i Khimioterapiya (1989), 34(11), 823-7, database is CAplus and MEDLINE.

Desorption mass spectrometry was a suitable method for identification and determination of a novel antimicrobial drug; decamethoxine (I). Thermal decomposition and mass spectrometric fragmentation of I under various ionization conditions are discussed.

Antibiotiki i Khimioterapiya published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C15H12O6, Quality Control of 38146-42-8.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics