Month: December 2022

Gal, Noga published the artcileMembrane interactions of ionic liquids: Possible determinants for biological activity and toxicity, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride, the publication is Biochimica et Biophysica Acta, Biomembranes (2012), 1818(12), 2967-2974, database is CAplus and MEDLINE.

Ionic liquids (ILs) are a class of diverse organic salts with relatively low m.ps. (below 100 °C) which have attracted considerable interest as a promising “green” substitute for organic solvents. The broad solvation properties of ILs and their high solubility in water, however, present health risks, in particular since it was shown that many ILs exhibit cytotoxic properties. In this context, interactions of ILs with the cellular membrane are believed to constitute a primary culprit for toxicity. We present a comprehensive biophys. and microscopy study of membrane interactions of a series of ILs having different side-chain compositions and lengths, and cationic head-group structures and orientations. The exptl. data reveal that the ILs studied exhibit distinct mechanisms of membrane binding, insertion, and disruption which could be correlated with their biol. activities. The results indicate, in particular, that both the side chain composition and particularly the head-groups of ILs constitute determinants for membrane activity and consequent cell toxicity. This work suggests that tuning membrane interactions of ILs should be an important factor for designing future compounds with benign environmental impact.

Biochimica et Biophysica Acta, Biomembranes published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Recommanded Product: N-Benzyl-N,N-dibutylbutan-1-aminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Roszkowski, Piotr published the artcileNovel (+)-3-carene derivatives and their application in asymmetric synthesis, COA of Formula: C7H13ClNNaO5S, the publication is Synthesis (2015), 47(4), 569-574, database is CAplus.

A simple synthetic procedure for the preparation of mono-N-tosylated 1,2-diamines derived from (+)-3-carene is described. (+)-3-Carene is transformed into the corresponding N-tosylaziridine using chloramine-T trihydrate. Subsequent ring-opening with NaN₃, followed by reduction of the azide function gives the optically pure mono-N-tosylated 1,2-diamine. This ligand is effective in asym. transfer hydrogenations of aromatic ketones. It can also be transformed into other chiral ligands by alkylation of the amino group for application in the addition of Et₂Zn to benzaldehydes.

Synthesis published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, COA of Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vishnumurthy, Kodumuru published the artcileNovel and efficient one-step parallel synthesis of dibenzopyranones via Suzuki-Miyaura cross coupling, Recommanded Product: 4-Chloro-2-hydroxyphenylboronic acid, the publication is Journal of Combinatorial Chemistry (2010), 12(5), 664-669, database is CAplus and MEDLINE.

Microwave-promoted novel and efficient one-step parallel synthesis of dibenzopyranones and heterocyclic analogs from bromo arylcarboxylates and o-hydroxyarylboronic acids via Suzuki-Miyaura cross coupling reaction is described. Spontaneous lactonization gave dibenzopyranones and heterocyclic analogs bearing electron-donating and -withdrawing groups on both aromatic rings in good to excellent yields.

Journal of Combinatorial Chemistry published new progress about 1238196-66-1. 1238196-66-1 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Phenol,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-hydroxyphenylboronic acid, and the molecular formula is C9H4F6O, Recommanded Product: 4-Chloro-2-hydroxyphenylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Vennerstrom, Jonathan L. published the artcileAntimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines, SDS of cas: 4569-86-2, the publication is Antimicrobial Agents and Chemotherapy (1995), 39(12), 2671-7, database is CAplus and MEDLINE.

In 1891, P. Guttmann and P. Ehrlich (1891) were the first to report the antimalarial properties of a synthetic, rather than a natural, material when they described the clin. cure of two patients after oral administration of a thiazine dye, methylene blue. Since that time, sporadic reports of the antimalarial properties of several xanthene and azine dyes related to methylene blue have been noted. We report here the results from a reexamination of the antimalarial properties of methylene blue, Janus green B, and three rhodamine dyes and disclose new antimalarial data for 16 com. available structural analogs of these dyes. The 50% inhibitory concentrations for the chloroquine-susceptible D6 clone and SN isolate and the chloroquine-resistant W2 clone of Plasmodium falciparum were determined by the recently described parasite lactate dehydrogenase enzyme assay. No cross-resistance to chloroquine was observed for any of the dyes. For the 21 dyes tested, no correlation was observed between antimalarial activity and cytotoxicity against KB cells. No correlation between log P (where P is the octanol/water partition coefficient) or relative catalyst efficiency for glucose oxidation and antimalarial activity or cytotoxicity was observed for the dyes as a whole or for the thiazine dyes. Thiazine dyes were the most uniformly potent structural class tested, and among the dyes in this class, methylene blue was notable for both its high antimalarial potency and selectivity.

Antimicrobial Agents and Chemotherapy published new progress about 4569-86-2. 4569-86-2 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is 3-Amino-7-(diethylamino)-5-phenylphenazin-5-ium chloride, and the molecular formula is C44H28ClFeN4, SDS of cas: 4569-86-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Shultz, Michael D. published the artcileStructure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases, Application of 3-(2,6-Dichlorophenyl)propanoic acid, the publication is Journal of Medicinal Chemistry (2013), 56(17), 7049-7059, database is CAplus and MEDLINE.

Tankyrases 1 and 2 are members of the poly(ADP-ribose) polymerase (PARP) family of enzymes that modulate Wnt pathway signaling. While amide- and lactam-based nicotinamide mimetics that inhibit tankyrase activity, such as XAV939, are well-known, the discovery and evaluation of a novel nicotinamide isostere that demonstrates selectivity over other PARP family members is reprted. The utilization of lipophilic efficiency-based structure-efficiency relationships (SER) to rapidly drive the evaluation of this series is demonstrated. These efforts led to a series of selective, cell-active compounds with solubility, physicochem., and in vitro properties suitable for further optimization.

Journal of Medicinal Chemistry published new progress about 51656-68-9. 51656-68-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Carboxylic acid,Benzene, name is 3-(2,6-Dichlorophenyl)propanoic acid, and the molecular formula is C15H19BO2, Application of 3-(2,6-Dichlorophenyl)propanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sureshkumar, Devarajulu published the artcileRegio- and Stereoselective Synthesis of Aziridino Epoxides from Cyclic Dienes, Synthetic Route of 7080-50-4, the publication is Journal of Organic Chemistry (2006), 71(4), 1653-1657, database is CAplus and MEDLINE.

Two different routes for the regio- and stereoselective synthesis of aziridino epoxides from cyclic dienes have been explored. The first strategy involves regiospecific aziridination of cyclic diene derivatives and subsequent epoxidation with m-CPBA to yield cis-aziridino epoxides as major products. The second strategy utilizes regiospecific epoxidation of cyclic diene derivatives followed by Sharpless aziridination to provide exclusively trans-aziridino epoxides. Synthesis of both enantiomers of cis-aziridino epoxides from (R)-(-)- and (S)-(+)-carvones are also reported.

Journal of Organic Chemistry published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C8H6ClNO, Synthetic Route of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Bigolin, Alisson published the artcileA novel sulfonamide derivative as a strong and selective apototic agent against hematological malignancies, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Chemical Papers (2020), 74(9), 2965-2976, database is CAplus.

Abstract: Currently available chemotherapeutic drugs against hematol. malignancies have several adverse effects and are associated with high mortality rates. Thus, in this study we evaluated the cytotoxic effect of 26 new sulfonamide derivatives on acute leukemia and multiple myeloma cells in order to try to discover a new selective and safe compound that might be used as a prototype for new chemotherapeutic agents. The most cytotoxic compound, DFS16, reduced the cell viability of K562, Jurkat and MM.1S cells in a concentration- and time- dependent manner and it was significantly less cytotoxic to non-tumor cells. On acute leukemia cells, sulfonamide DFS16 activated intrinsic and extrinsic apoptosis with Bax/Bcl-2 inversion, increased FasR expression and m loss. In K562, DFS16 induced apoptosis by caspase-3 activation, while in Jurkat, it induced AIF release and caspase-3 independent apoptosis. In multiple myeloma, DFS16 induced cell cycle arrest at the G2/M phase and apoptosis with m loss. Altogether, the results suggest that the new sulfonamide derivative DFS16 induces apoptotic-like cell death in acute leukemia and multiple myeloma cells. DFS16 is a promising new mol. that could be used as a prototype for the development of chemotherapeutics against hematol. malignancies.

Chemical Papers published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Safety of ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Cross, R. Matthew published the artcileOptimization of 1,2,3,4-Tetrahydroacridin-9(10H)-ones as Antimalarials Utilizing Structure-Activity and Structure-Property Relationships, Synthetic Route of 209919-30-2, the publication is Journal of Medicinal Chemistry (2011), 54(13), 4399-4426, database is CAplus and MEDLINE.

Antimalarial activity of 1,2,3,4-tetrahydroacridin-9(10H)-ones (THAs) has been known since the 1940s and has garnered more attention with the development of the acridinedione floxacrine in the 1970s and analogs thereof such as WR 243251 in the 1990s. These compounds failed just prior to clin. development because of suboptimal activity, poor solubility, and rapid induction of parasite resistance. Moreover, detailed structure-activity relationship (SAR) studies of the THA core scaffold were lacking and SPR studies were nonexistent. To improve upon initial findings, several series of 1,2,3,4-tetrahydroacridin-9(10H)-ones were synthesized and tested in a systematic fashion, examining each compound for antimalarial activity, solubility, and permeability. Furthermore, a select set of compounds was chosen for microsomal stability testing to identify physicochem. liabilities of the THA scaffold. Several potent compounds (EC₅₀ < 100 nM) were identified to be active against the clin. relevant isolates W2 and TM90-C2B while possessing good physicochem. properties and little to no cross-resistance.

Journal of Medicinal Chemistry published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8BClO2, Synthetic Route of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Golzadeh, Robab published the artcileGreen synthesis of methadone in eutectic solvent, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Main Group Chemistry (2021), 20(4), 463-474, database is CAplus.

Synthesis of di-Ph acetonitrile with 1-dimethylamino-2-chloropropane by a eutectic’s solvent was described. In addition, methadone I was synthesized from the reaction of 2,2-diphenyl-4-dimethylaminovaleronitrile with Et magnesium bromide in the presence of solvent eutectic, which was in optimal and environmentally compatible conditions and by principles of green chem.

Main Group Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Name: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ghosal, Nirnita Chakraborty published the artcileA Mild and Efficient Method for the Syntheses and Regioselective Ring-Opening of Aziridines, Formula: C7H13ClNNaO5S, the publication is SynOpen (2017), 1(1), 0015-0023, database is CAplus.

A new synthetic method for the synthesis of aziridines using Chloramine-T as an effective reagent in the presence of NH₂OH·HCl and NaIO₄. The same combination of NH₂OH·HCl and NaIO₄ was also very effective for nucleophilic ring opening of aziridines.

SynOpen published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C7H13ClNNaO5S, Formula: C7H13ClNNaO5S.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics