Month: December 2022

Sharath, N. published the artcileSynthesis, DNA Binding, and Photonuclease Activity of New Tetraaza Macrocyclic Constrained Isoxazole Rings as Subunit in Metal Complexes, Category: chlorides-buliding-blocks, the publication is Nucleosides, Nucleotides & Nucleic Acids (2012), 31(11), 813-829, database is CAplus and MEDLINE.

The DNA-binding and photonuclease activity of newly synthesized tetra-azamacrocyclic ligand L (C₃₂H₃₂N₈O₄) and its complexes of type [MLCl₂] and [ML]Cl₂ (where M = Co(II), Fe(II) and Cu(II)); L = N,N’-[3-(4-{5-[(2-amino-ethylamino)-methyl]-isoxazol-3yl}-phenyl)-isoxazol-5-yl methyl-ethane-1,2-diamine] are specified. An octahedral geometry has been proposed for Fe(II) and Co(II) complexes, while the Cu(II) complex has a square planar environment. The absorption spectral results indicate that the complexes bind with the base pairs of DNA, with an intrinsic binding constant K_b of, and complexes found to be 3.2 × 10⁴ M^-1, 5.3 × 10⁴ M^-1, and 4.2 × 10⁴ M^-1, resp., in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2. The large enhancement in the relative viscosity of DNA on binding to the complexes supports the proposed DNA binding modes. The viscosity and thermal denaturation studies sustain the effective intercalation with DNA. The DNA photocleavage studies demonstrated that compounds exhibit significant photonuclease activity by a concentration dependent on singlet oxygen mediated mechanism.

Nucleosides, Nucleotides & Nucleic Acids published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C4H10BBrO2, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Pedreira, Julia G. B. published the artcileBioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors, Application In Synthesis of 620-20-2, the publication is Journal of Medicinal Chemistry (2020), 63(13), 7347-7354, database is CAplus and MEDLINE.

The recent disclosure of type I 1/2 inhibitors for p38α MAPK demonstrated how the stabilization of the R-spine can be used as a strategy to greatly increase the target residence time (TRT) of inhibitors. Herein, for the first time, we describe N-acylhydrazone and selenophene residues as spine motifs, yielding metabolically stable inhibitors with high potency on enzymic, NanoBRET, and whole blood assays, improved metabolic stability, and prolonged TRT.

Journal of Medicinal Chemistry published new progress about 620-20-2. 620-20-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 3-Chlorobenzylchloride, and the molecular formula is C7H6Cl2, Application In Synthesis of 620-20-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Masuda, Takeshi published the artcileSugar-induced stereoselectivity in the Fe³⁺-complexation of boronic acid-appended trihydroxamate-type artificial siderophores, Synthetic Route of 332154-58-2, the publication is Supramolecular Chemistry (2000), 11(4), 301-314, database is CAplus.

Two linear- and two tripodal-trihydroxamate siderophore mimics, suspending phenylboronic acid as the sugar-binding site, have been newly prepared These siderophore mimics strongly bind Fe³⁺ ions to give rise to the ligand-Fe³⁺ 1:1 complexes over a wide range of pH 2 to 11. CD spectra of these complexes in the presence of a sugar, D-fructose, exhibit moderately strong bisignate Cotton effects of first neg. and second pos. signs in aqueous alk. media. The sign and extent of the observed CD signals depend largely on the solution pH and the concentration and absolute configuration of the bound sugars, implying that the phenylboronate-sugar covalent interactions are capable of inducing a chirality around the metal center.

Supramolecular Chemistry published new progress about 332154-58-2. 332154-58-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,acyl chloride,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (3-(Chlorocarbonyl)phenyl)boronic acid, and the molecular formula is C7H6BClO3, Synthetic Route of 332154-58-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wagh, Ravindra B. published the artcileSilica chloride: An efficient promoter for oxidation of arylboronic acids to phenols, Quality Control of 209919-30-2, the publication is Tetrahedron Letters (2017), 58(33), 3323-3326, database is CAplus.

This work reports simple, highly efficient protocol for the oxidation of arylboronic acids. Various arylboronic acids were selectively and completely converted into their corresponding oxidized phenols using H₂O₂ as an oxidant in presence of catalytic amount of silica chloride. The results show that silica chloride is a suitable and efficient promoter for the oxidation of arylboronic acids. Heterogeneous catalyst, mild reaction conditions, easy availability of the reagent, easy work-up, excellent yield of corresponding phenols, short reaction time and broad substrate scope makes this protocol attractive and a practical alternative to the existing methods.

Tetrahedron Letters published new progress about 209919-30-2. 209919-30-2 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Boronic acid and ester,Benzene,Boronic Acids,Boronic acid and ester, name is 4-Chloro-2-methylphenylboronic acid, and the molecular formula is C7H8FNO2S, Quality Control of 209919-30-2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Silvestri, Maximilian A. published the artcileDesign, Synthesis, Anti-HIV Activities, and Metabolic Stabilities of Alkenyldiarylmethane (ADAM) Non-nucleoside Reverse Transcriptase Inhibitors, Computed Properties of 19652-33-6, the publication is Journal of Medicinal Chemistry (2004), 47(12), 3149-3162, database is CAplus and MEDLINE.

The alkenyldiarylmethane (ADAM) HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) are effective anti-HIV agents in cell culture. However, the potential clin. utility of the ADAMs is expected to be limited by the presence of Me ester moieties that are likely to be metabolized by nonspecific esterases in blood plasma to biol. inactive carboxylic acid derivatives The present investigation was therefore undertaken to investigate the anti-HIV activities of the ADAMs vs. HIV-1_IIIB and HIV-2_ROD in MT-4 cells and the stabilities of the biol. active ADAMs in rat plasma. Synthesis of most of the ADAMs I (R¹ = R⁴ = CO₂Me, R² = MeO, R³ = Br, Cl, Me, cyano; R¹ = CO₂Me, R² = MeO, R³ = Br, Cl, Me, R⁴ = CC, CH:CH, Ph, CO₂-n-Pr, CO₂CHMe₂; etc.) were reported previously. However, 13 of the 32 compounds, I (R¹ = CO₂Me, R² = MeO, R³ = Br, R⁴ = CH₂OMe; R¹ = R⁴ = CH₂OH, R² = MeO, R³ = Cl; R¹ = R⁴ = CH₂OMe, R² = MeO, R³ = Cl; etc.), tested were newly synthesized. For example, reacting Me 5-methoxypentanoate with benzophenone II gave I (R¹ = CO₂Me, R² = MeO, R³ = Br, R⁴ = CH₂OMe) in 24% yield. The ADAMs displayed a wide range of metabolic stabilities in rat plasma, with half-lives ranging from 0.9 to 76.6 min. A wide assortment of structural modifications was tolerated, with 18 of the 32 compounds tested displaying EC₅₀ values between 0.3 and 3.7 μM vs. HIV-1_IIIB in MT-4 cells, 3 compounds in the EC₅₀ = 13.2-35.4 μM range, and the remaining compounds inactive. Consistent with the mechanism of action of the ADAMs as NNRTIs, they were inactive or displayed comparatively low activity vs. HIV-2_ROD. The replacement of the two aromatic Me ester substituents in one of the most active ADAMs (EC₅₀ = 0.6 μM) with two Me thioester groups resulted in an increase in plasma half-life from 5.8 to 55.3 min, while maintaining the antiviral potency at the EC₅₀ = 1.8 μM level. At the same time, the bis(thioester) modification was less cytotoxic to uninfected MT-4 cells, with a CC₅₀ of >224 μM vs. 160 μM for the parent compound

Journal of Medicinal Chemistry published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C10H16Br3N, Computed Properties of 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Fukuda, Takashi published the artcileNectriatide, a potentiator of amphotericin B activity from Nectriaceae sp. BF-0114, HPLC of Formula: 42074-68-0, the publication is Journal of Natural Products (2019), 82(10), 2673-2681, database is CAplus and MEDLINE.

A new compound, designated nectriatide (1), was isolated as a potentiator of amphotericin B (AmB) activity against Candida albicans from the culture broth of Nectriaceae sp. BF-0114. This structure was elucidated based on spectroscopic analyses (1D and 2D NMR data), chem. methods, and total synthesis. Compound 1 was a unique cyclotetrapeptide consisting of L-N-methyltyrosine, anthranilic acid, L-alanine, and L-valine. Compound 1 and several synthetic derivatives, including linear peptides, potentiated AmB activity against C. albicans by up to 16-fold (the MIC value of AmB decreased from 0.5μg/mL to 0.031μg/mL in combination with test compound).

Journal of Natural Products published new progress about 42074-68-0. 42074-68-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Benzyl chloride,Benzene, name is 2-Chlorotrityl chloride, and the molecular formula is C19H14Cl2, HPLC of Formula: 42074-68-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Konuki, Kaname published the artcileEnantiomeric purity enrichment of (R)-tetrahydrothiophene-3-ol sulfonyl derivatives by crystallization, Synthetic Route of 21286-54-4, the publication is Tetrahedron: Asymmetry (2014), 25(24), 1581-1589, database is CAplus.

(R)-Tetrahydrothiophen-3-yl sulfonates I [R = R¹SO₂; R¹ = 4-MeC₆H₄, Me, i-Pr, Bu, Ph, PhCH₂, 4-MeOC₆H₄, 4-ClC₆H₄, 2,4,6-Me₃C₆H₂, 4-AcNHC₆H₄, 2,5-(MeO)₂C₆H₃, 3,4-(MeO)₂C₆H₃, 1-naphthyl, 2-naphthyl, 5-dimethylamino-1-naphthyl, (+)-10-camphyl, (-)-10-camphyl] were prepared in 68-74% ee from the corresponding nonracemic alc. I (R = H) and sulfonyl chlorides R¹SO₂Cl for recrystallization to increase the enantiomeric purities without using seed crystals. The improvement in enantiopurity on recrystallization depended on the identity of the sulfonate group. I (R = Ph, Me, i-Pr, Bu) did not form crystals under appropriate conditions; in most of the remaining cases, the enantiopurity of the sulfonates isolated from the mother liquor were higher than those of the original sulfonates, while recrystallization of I (R = H, 5-dimethylamino-1-naphthalenesulfonyl) yielded crystals of higher enantiopurities than the starting materials. In particular, crystallization of the diastereomeric camphorsulfonates I [R = (+)-10-camphorsulfonyl, (-)-10-camphorsulfonyl] yielded mother liquors in which the sulfonates were isolated in 100% de and 95% de, resp.

Tetrahedron: Asymmetry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Synthetic Route of 21286-54-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wan, Zhongliang published the artcileSynthesis and Biological Activity of 3-N-Substituted Estrogen Derivatives as Breast Cancer Agents, Product Details of C5H13Cl2N, the publication is Mini-Reviews in Medicinal Chemistry (2013), 13(9), 1381-1388, database is CAplus and MEDLINE.

3-N-substituted-estrogen derivatives I [R = 3-morpholinopropyl, (CH₂)₃NMe₂, CH(Me)CH₂NMe₂, 3-piperidinopropyl, 3-aminopropyl, etc.] were synthesized and characterized. Their antiproliferative activities against human ER(+) MCF-7 (breast), ER(-) MDA-MB-231 (breast) and Ishikawa (endometrial) cancer cell lines were determined after 72 h drug exposure employing CellTiter-Glo assay at concentrations ranging from (0.01-100,000 nM). The antiproliferative activities of these compounds were compared to tamoxifen (TAM), 4-hydroxytamoxifen (4-OHT, active metabolite of tamoxifen) and raloxifene (RAL). In vitro results indicated that compound I (R = 3-piperidinopropyl) (IC₅₀ = 12μM) displayed comparable antiproliferative activity against MDA-MB 231 cell line; while compounds I [R = (CH₂)₃NMe₂, CH(Me)CH₂NMe₂, (CH₃)₃NEt₂] (IC₅₀ = 12μM) displayed higher activity against MCF-7 and Ishikawa cell lines, in comparison to TAM activity (19-33μM).

Mini-Reviews in Medicinal Chemistry published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C13H17BrO3, Product Details of C5H13Cl2N.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Senthamarai, Thirusangumurugan published the artcileExpedient Synthesis of N-Methyl- and N-Alkylamines by Reductive Amination using Reusable Cobalt Oxide Nanoparticles, Safety of 3-Chloro-4-fluoronitrobenzene, the publication is ChemCatChem (2018), 10(6), 1235-1240, database is CAplus.

N-Methyl- and N-alkylamines represent important fine and bulk chems. that are extensively used in both academic research and industrial production Notably, these structural motifs are found in a large number of life-science mols. and play vital roles in regulating their activities. Therefore, the development of convenient and cost-effective methods for the synthesis and functionalization of amines by using earth-abundant metal-based catalysts is of scientific interest. In this regard, an expedient reductive amination process for the selective synthesis of N-methylated and N-alkylated amines by using nitrogen-doped, graphene-activated nanoscale Co₃O₄-based catalysts, is reported. Starting from inexpensive and easily accessible nitroarenes or amines and aqueous formaldehyde or aldehydes in the presence of formic acid, this cost-efficient reductive amination protocol allows the synthesis of various N-methyl- and N-alkylamines, amino acid derivatives, and existing drug mols.

ChemCatChem published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C9H9F5Si, Safety of 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Jagadeesh, Rajenahally V. published the artcileMOF-derived cobalt nanoparticles catalyze a general synthesis of amines, Product Details of C6H3ClFNO2, the publication is Science (Washington, DC, United States) (2017), 358(6361), 326-332, database is CAplus and MEDLINE.

The development of base metal catalysts for the synthesis of pharmaceutically relevant compounds remains an important goal of chem. research. Here, we report that cobalt nanoparticles encapsulated by a graphitic shell are broadly effective reductive amination catalysts. Their convenient and practical preparation entailed template assembly of cobalt-diamine-dicarboxylic acid metal organic frameworks on carbon and subsequent pyrolysis under inert atm. The resulting stable and reusable catalysts were active for synthesis of primary, secondary, tertiary, and N-methylamines (more than 140 examples). The reaction couples easily accessible carbonyl compounds (aldehydes and ketones) with ammonia, amines, or nitro compounds, and mol. hydrogen under industrially viable and scalable conditions, offering cost-effective access to numerous amines, amino acid derivatives, and more complex drug targets.

Science (Washington, DC, United States) published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Product Details of C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics