Month: December 2022

Jiang, Chengjun published the artcileChemoselective Transfer Hydrogenation of Nitroarenes Catalyzed by Highly Dispersed, Supported Nickel Nanoparticles, Name: 3-Chloro-4-fluoronitrobenzene, the publication is ACS Catalysis (2015), 5(8), 4814-4818, database is CAplus.

A recyclable highly dispersed Ni/SiO₂ catalyst was prepared by at. layer deposition. Chemoselective reduction of nitroarenes was studied using the prepared Ni/SiO₂ as the catalyst and hydrazine hydrate as a hydrogen donor. Different kinds of nitroarenes were converted to the corresponding anilines with high yields. The high activity of the catalysts could be a result of the highly dispersed Ni nanoparticles.

ACS Catalysis published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, Name: 3-Chloro-4-fluoronitrobenzene.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Ge, Dandan published the artcilePreparation of new hydrophobic deep eutectic solvents and their application in dispersive liquid-liquid microextraction of Sudan dyes from food samples, Category: chlorides-buliding-blocks, the publication is Analytical and Bioanalytical Chemistry (2021), 413(15), 3873-3880, database is CAplus and MEDLINE.

In this work, a new generation of hydrophobic deep eutectic solvents (DESs) was prepared using eugenol (as hydrogen bond donor) and benzyltriethylammonium bromide, benzyltributylammonium bromide, benzyltriethylammonium chloride and benzyltributylammonium chloride (as hydrogen bond acceptor) in different molar ratios. These DESs were applied to vortex-assisted dispersive liquid-liquid microextraction of Sudan dyes from food samples, followed by high-performance liquid chromatog. determination The influencing parameters, including the type of DES, amount of DES, extraction time, solution pH and salt addition, were investigated and optimized. Under the optimized conditions, a linear range of 2-1000 ng mL-1 with determination coefficients of <0.999 was obtained. Limits of detection and limits of quantification were in the range of 0.5 to 1 ng mL-1 and 2 to 3 ng mL-1, resp. The proposed method was successfully used in the determination of Sudan dyes in chili sauce, chili powder and ketchup, and satisfactory recoveries of between 89.9 and 119.3% were obtained, with relative standard deviations in the range of 0.1-6.8%. The proposed method is simple, green and efficient, and can be applied to determine Sudan dyes in complex matrixes.

Analytical and Bioanalytical Chemistry published new progress about 23616-79-7. 23616-79-7 belongs to chlorides-buliding-blocks, auxiliary class Phase Transfer Catalyst, name is N-Benzyl-N,N-dibutylbutan-1-aminium chloride, and the molecular formula is C19H34ClN, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Seelam, Mohan published the artcileAn efficient methodology for the synthesis of thioureas from amine mediated by a cobalt source, HPLC of Formula: 3696-23-9, the publication is Tetrahedron Letters (2016), 57(48), 5297-5300, database is CAplus.

The cheap, readily available and air stable cobalt catalyst was used as the desulfurization agent for the conversion of aniline to thioureas in one pot three step reaction under mild reaction conditions. The reactions are rapid and facile and accomplished at room temperature

Tetrahedron Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C17H20ClN3, HPLC of Formula: 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Qiang-Qiang published the artcileDirect Wittig Olefination of Alcohols, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, the publication is Journal of Organic Chemistry (2018), 83(1), 296-302, database is CAplus and MEDLINE.

Benzylic alcs. such as benzyl alc. underwent chemoselective and diastereoselective Wittig olefinations with alkyltriphenylphosphonium salts such as 2-pyridinylmethyltriphenylphosphonium chloride mediated by t-BuOK and air in THF to give aryl alkenes such as (E)-2-(2-phenylethenyl)pyridine in 8-93% yields and in ≥8:1 E:Z diastereoselectivities. Benzylic alcs. were thus directly transformed to olefins without pre-preparation of either aryl aldehydes or ylides. 1,2-Benzenedimethanol underwent chemoselective Wittig olefination to give mono- or dialkenylbenzenes; an unsym. dialkenylbenzene was also prepared The method was used to prepare the potential antitumor agent DMU-212, resveratrol, and nonracemic hexahelicenol enantiomers. The mechanism and kinetics of the olefination were studied.

Journal of Organic Chemistry published new progress about 21286-54-4. 21286-54-4 belongs to chlorides-buliding-blocks, auxiliary class Chiral,Chloride,Sulfonyl chlorides,Aliphatic cyclic hydrocarbon,Ketone, name is ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride, and the molecular formula is C10H15ClO3S, Recommanded Product: ((1S,4R)-7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonyl chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Remy, Sandrine published the artcileFunctionalization of zinc oxide nanorods with diarylethene-based photochromic compounds, Quality Control of 219537-97-0, the publication is Dyes and Pigments (2011), 89(3), 266-270, database is CAplus.

Two diarylethene mols. functionalized with a carboxylic acid function were grafted onto the surface of zinc oxide nanorods. Photochromic studies based on electronic absorption spectroscopy in solution showed that the switching units operate in a bidirectional mode, allowing both ring closure and ring-opening processes to take place successively in photochem. sequences combining irradiations of the open species at 300 nm and the closed ones at 500 nm. Depending on the mol. structure, some losses were observed presumably due to photodegradation Compound 2 containing a terminal Ph unit provides a longer conjugation pathway, thus offering red-shifted electronic absorption and better photochem. stability.

Dyes and Pigments published new progress about 219537-97-0. 219537-97-0 belongs to chlorides-buliding-blocks, auxiliary class Fused/Partially Saturated Cycles,Cyclopentenes, name is 5-Chloro-3-[2-(5-chloro-2-methylthien-3-yl)cyclopent-1-en-1-yl]-2-methylthiophene, and the molecular formula is C15H14Cl2S2, Quality Control of 219537-97-0.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mukhtar, Asma published the artcileSynthesis of Chalcones as Potential α-Glucosidase Inhibitors, In-Vitro and In-Silico Studies, HPLC of Formula: 19652-33-6, the publication is ChemistrySelect (2021), 6(37), 9933-9940, database is CAplus.

Seventeen chalcones derivatives I [R = 2-HO-3-ClC₆H₃, 4-NMe₂C₆H₄, 2-Br-4,5-(OMe)₂C₆H₂, etc.; R¹ = 3-MeC₆H₄, 4-MeC₆H₄, 4-ClC₆H₄, etc.] were synthesized by reactions of diversely substituted aldehydes with various ketones. The structures of compounds were characterized by using NMR (NMR) spectroscopy, mass spectrometry (MS) and carbon, hydrogen, nitrogen (CHN) anal. These synthetic mols. were tested for α-glucosidase inhibitory activity. Acarbose was used as a standard drug and pos. control in this study. Compound I [R = 2-HO-3,5-Cl₂C₆H₂; R¹ = 4-MeC₆H₄] with hydroxy and chloro substitutions was found to be the most active compound and a novel compound of this library. Active mols. were subjected to in silico study to determine binding interactions with target site of α-glucosidase.

ChemistrySelect published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, HPLC of Formula: 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Mukhtar, Asma published the artcileIndane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies, Computed Properties of 19652-33-6, the publication is Medicinal Chemistry (Sharjah, United Arab Emirates) (2021), 17(8), 887-902, database is CAplus and MEDLINE.

Diabetes mellitus is one of the most chronic metabolic disorders. Since past few years, our research group had synthesized and evaluated libraries of heterocyclic compounds against α and β-glucosidase enzymes and found encouraging results. The current study comprises of evaluation of indane-1,3-dione as antidiabetic agents based on our previously reported results obtained from closely related moiety isatin and its derivatives A library of twenty three indane-1,3-dione derivatives (1-23) was synthesized and evaluated for α and β-glucosidase inhibitions. Moreover, in silico docking studies were carried out to investigate the putative binding mode of selected compounds with the target enzyme. The indane-1,3-dione derivatives (1-23) were synthesized by Knoevenagel condensation of different substituted benzaldehydes with indane-1,3-dione under basic condition. The structures of synthetic mols. were deduced by using different spectroscopic techniques, including ¹H-, ¹³C-NMR, EI-MS, and CHN anal. Compounds (1-23) were evaluated for α and β-glucosidase inhibitions by adopting the literature protocols. Off twenty three, eleven compounds displayed good to moderate activity against α- glucosidase enzyme, nonetheless, all compounds exhibited less than 50% inhibition against β- glucosidase enzyme. Compounds 1, 14, and 23 displayed good activity against α-glucosidase enzyme with IC₅₀ values of 2.80 ± 0.11, 0.76 ± 0.01, and 2.17 ± 0.18 μM, resp. The results have shown that these compounds have selectively inhibited the α-glucosidase enzyme. The in silico docking studies also supported the above results and showed different types of interactions of synthetic mols. with the active site of enzyme. The compounds 1, 14, and 23 have shown good inhibition against α-glucosidase and may potentially serve as lead for the development of new therapeutic representatives.

Medicinal Chemistry (Sharjah, United Arab Emirates) published new progress about 19652-33-6. 19652-33-6 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Bromide,Benzene,Phenol,Aldehyde, name is 5-Bromo-3-chloro-2-hydroxybenzaldehyde, and the molecular formula is C7H4BrClO2, Computed Properties of 19652-33-6.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Dabholkar, Vijay V. published the artcileMicrowave assisted synthesis of 5H-2(substituted)phenylimino-5-phenyloxazole-4-ones, Category: chlorides-buliding-blocks, the publication is Heterocyclic Letters (2015), 5(3), 419-423, database is CAplus.

A series of 5H-2(substituted)phenylimino-5-phenyloxazole-4-ones and 5H-2(substituted)phenylimino-5-phenylthiazole-4-ones was synthesized by interaction of ethyl-2-bromo-2-phenylethanoate with urea and thiourea under microwave condition resp. The technique consumes less time and gaves excellent yields. These compounds were also synthesized by conventional method. Structure of compounds were elucidated on the basis of spectral and laboratorial techniques. Further, the compound were scanned for their biol. activities.

Heterocyclic Letters published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Merchant, J. R. published the artcileSubstitution in the benzopyrone series. II. Sulfonation of coumarin derivatives, Related Products of chlorides-buliding-blocks, the publication is Journal of the Indian Chemical Society (1957), 35-41, database is CAplus.

ClSO₃H (2 moles) added gradually with cooling to coumarin, and the mixture heated 2 hrs. at 100°, cooled, and poured over crushed ice gave a mixture of the 6-SO₃H (I) and 6-SO₂Cl (m. 119-20°) compounds; S-benzylisothiuronium (II) derivative of I, m. 212-14°. The following compounds were treated similarly, the figures after each referring to moles ClSO₃H, temperature, and hrs. of heating, resp., and the products of sulfonation being given last: coumarin, 6, 130-40°, 3, the 3,6-di-SO₃H (III) (II derivative, m. 194-6°) and 3,6-di-SO₂Cl (m. 173-5°) compounds (amide, m. above 270°; anilide, m. 218-20°); 6-nitrocoumarin, 10, 130-40°, 4, the 3-SO₃H (IV) (II derivative, m. 230-2°) and 3-SO₂Cl (m. 204-5°) compounds (amide, m. above 290°; anilide, m. 130°); 7-hydroxy-4-methylcoumarin (V), 4, 100°, 2, the 6-SO₃H (VI) (II derivative, m. 180-2°) and 6-SO₂Cl (VII) (m. 178-80°) compounds (amide, m. above 290°; anilide, m. 245-7°); V, 4, 130-40°, 4, the 6,8-di-SO₃H compound; V, 8, 140°, 4, the 3,6,8-tri-SO₃H compound; 7-hydroxy-3,6-dibromo-4-methylcoumarin, 10, 100°, 2, the 8-SO₃H compound (VIII) (II derivative, m. 205-6°); 7-hydroxy-3,8-dibromo-4-methylcoumarin, 7.5, 100°, 2, the 6-SO₃H [II derivative, m. 238° (decomposition)] and 6-SO₂Cl (IX) [m. 210° (decomposition)] compounds (anilide, m. 210-12°); 7-methoxy-4-methylcoumarin (X), 4.3, 100°, 2, the 6-SO₃H (XI) [m. 175° (decomposition); II derivative, m. 250°] and 6-SO₂Cl (XII) (m. 203-4°) compounds (amide, m. above 310°; anilide, m. 209-10°); X, 8, 60°, 3 (in dry CHCl₃), the 3,6-di-SO₃H (XIII) [II derivative, m. 244° (decomposition)] and 3,6-di-SO₂Cl (m. 230-2°) compounds (anilide, m. 245-7°); X, excess ClSO₃H, 130-40°, a demethylated trisulfonic acid; 7-methoxy-3-bromo-4-methylcoumarin, 4, 100°, 2, the 6-SO₃H [II derivative, m. 280° (decomposition)] and 6-SO₂Cl (XIV) (m. 227-9°) compounds (anilide, m. 236-8°); 7-hydroxy-6-carbomethoxy-4-methylcoumarin, 1, 60°, 2 (in dry CHCl₃); 7-hydroxy-6-carboxy-4-methyl-8-coumarin sulfonic acid (XV) (II derivative, m. 209-11°) + unchanged substance; 7-hydroxy-6-carboxy-4-methylcoumarin, 4, 100°, 2, the 3,8-di-SO₃H compound (XVI). The position of the SO₃H group in I and III was proved by oxidation of the Na salt with alk. permanganate to give, in each case, 5-sulfosalicylic acid (II derivative, m. 194-6°). The same treatment of IV gave 5-nitrosalicylic acid, m. 227-8°. Bromination of VI (Na salt) with 1 mole Br in HOAc gave the 3,6,8-tri-Br compound, m. 250-2°, as did also bromination of VIII. VII (1 g. in 10 cc. glacial HOAc) treated hot with 11 cc. 10% Br in HOAc and left 6 hrs. at room temperature gave IX. XII brominated likewise yielded XIV. The Na salt of XI heated 15 min. with 2 moles Br in HOAc and poured into H₂O gave the 3,6-di-Br compound, m. 240° (from HOAc), as did XIII (di-Na salt) when treated with 3 moles Br. Oxidation of XI with alk. permanganate gave 2,4,5-HO(MeO)(HO₃S)C₆H₂ CO₂H (XVII) [II derivative, m. 228-30° (decomposition)], which upon bromination of its Na salt yielded the 5-Br compound, m. 251-2°. The structure of 5,2,4-HO₃S(HO)₂C₆H₂CO₂H (II derivative, m. 201-2°) obtained by Senhöfer and Brünner [Chem. Zentr. 1, 566(1879)] by sulfonating β-resorcylic acid was confirmed by its methylation to XVII. Bromination of XV and XVI gave in each case the 3,8-di-Br compound, m. 284-6° (decomposition).

Journal of the Indian Chemical Society published new progress about 10543-42-7. 10543-42-7 belongs to chlorides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Chloride,Sulfonyl chlorides,Ester, name is Coumarin-6-sulfonyl chloride, and the molecular formula is C9H5ClO4S, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Wambaugh, John F. published the artcileHigh-Throughput Models for Exposure-Based Chemical Prioritization in the ExpoCast Project, Computed Properties of 7080-50-4, the publication is Environmental Science & Technology (2013), 47(15), 8479-8488, database is CAplus and MEDLINE.

USEPA must characterize potential risks to human health and the environment associated with manufacture and use of thousands of chems. High-throughput screening (HTS) for biol. activity allows the ToxCast research program to prioritize chem. inventories for potential hazard. Similar capabilities to estimate exposure potential would support rapid, risk-based prioritization for chems. with limited information; this work proposes a framework for high-throughput exposure assessment. To demonstrate its application, an anal. was conducted to predict human exposure potential for chems. and estimate prediction uncertainty by comparison with biomonitoring data. In total, 1936 chems. were evaluated using far-field mass balance human exposure models (USEtox, RAIDAR) and an indicator for indoor and/or consumer use. These predictions were compared to exposures inferred by Bayesian anal. of urine concentrations for 82 chems. reported in the National Health and Nutrition Examination Survey (NHANES). Joint regression of all factors provided a calibrated consensus prediction, the variance of which served as an empirical determination of uncertainty to prioritize absolute exposure potential. Information on use was most predictive; generally, chems. above the limit of detection in NHANES had consumer/indoor use. Coupled with hazard HTS, exposure HTS can assign risk earlier in decision processes. High-priority chems. become targets for further data collection.

Environmental Science & Technology published new progress about 7080-50-4. 7080-50-4 belongs to chlorides-buliding-blocks, auxiliary class Halogenation Reagent,Inhibitor, name is Sodium chloro(tosyl)amide trihydrate, and the molecular formula is C5H10BNO2, Computed Properties of 7080-50-4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics