Month: December 2022

Nosach, L. V. published the artcileAdsorption modification of finely divided silica with nonvolatile organic compounds in a gaseous dispersion medium, COA of Formula: C38H74Cl2N2O4, the publication is Fizika i Khimiya Tverdogo Tila (2006), 7(3), 540-543, database is CAplus.

An adsorption modification has been examined of high disperse silica with polymers an non-volatile organic compounds in a gaseous dispersion medium. This method has been shown to be more effective one than that of liquid phase impregnation. The solvation of modificator mols. has been found to be the main factor governing the process of modifying high disperse silica with polymers and bioactive compounds

Fizika i Khimiya Tverdogo Tila published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, COA of Formula: C38H74Cl2N2O4.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Gerashchenko, I. I. published the artcileCompositions of highly dispersed silica with trypsin and a cationic surfactant obtained by a mechanosorption method, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) (2001), 35(2), 75-77, database is CAplus.

As part of the effort to develop a technol. for enzyme-containing drug compositions, the effect of cationic surfactants on the stability of trypsin comminuted jointly with a highly dispersed silica in a ball mill was examined The experiment used com. crystalline trypsin with a specific activity of not less than 10 TU/g, a highly dispersed silica in the form of Aerosil A-300 grade, and pharmacopeial preparations of ethonium and decamethoxine. Results indicate that the preliminary incubation of ethonium with trypsin results in a significant stabilization of the enzyme. Based on the results, the high enzymic activity retained in the products of mechanochem. processing of trypsin compositions with highly dispersed silica and cationic surfactant may be explained by the stabilizing action of the latter component. The technol. of obtaining mech. dispersed products with preset properties must include two sequential stages, namely, the initial mechanosorption immobilization of a cationic surfactant on the highly dispersed silica surface, followed by the mechanochem. processing of this modified carrier with the enzyme.

Pharmaceutical Chemistry Journal (Translation of Khimiko-Farmatsevticheskii Zhurnal) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Brovko, V. S. published the artcileHydrosilylation of unsaturated compounds in the presence of thiourea complexes of platinum(II) and palladium(II), Related Products of chlorides-buliding-blocks, the publication is Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) (1987), 60(11), 2554-6, database is CAplus.

Treating 1-hexene or PhCCH with MeSiHCl₂ in the presence of the title catalysts, e.g., [Pt(NH₂CSNH₂)₄][BPh₄]₂ (I), cis-[Pt(PhNCSNHR)₂]Cl₂ (II, R = α-pyridyl), [Pd(PhNHCSNHPh)₄]²⁺ (bound on ion-exchange resin KRS-20P), gave BuCH₂CH₂SiCl₂Me or E-PhCH:CHSiCl₂Me, resp., with nearly 100% selectivity and 90-100% yields with I or II as catalysts.

Zhurnal Prikladnoi Khimii (Sankt-Peterburg, Russian Federation) published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, Related Products of chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Volyanskii, Yu. L. published the artcileEffect of decametoxin on pathogenic staphylococci, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, the publication is Mikrobiologichnii Zhurnal (1934-1977) (1971), 33(4), 503-6, database is CAplus.

The bactericidal concentrations of decametoxin, a derivative of decamethylenediamine [646-25-3], tested on 648 pathogenic strains of staphylococci ranged between 0.125 and 50 μg/ml. At 2.5 and 25 μg/ml decametoxin decreased the activity of catalase and peroxidase in Staphylococcus aureus.

Mikrobiologichnii Zhurnal (1934-1977) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C7H5Br2F, Name: N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Palii, G. K. published the artcileSensitivity of microflora isolated from babies with respiratory tract diseases to decamethoxin and antibiotics, Category: chlorides-buliding-blocks, the publication is Mikrobiologichnii Zhurnal (1934-1977) (1974), 36(3), 347-9, database is CAplus.

Staphylococcal strains, isolated from pharynx, skin, and feces of babies with respiratory tract diseases, were sensitive to decamethoxin (I) [38146-42-8] (0.12-7.8 μg/ml). However, most of the 118 strains were resistant to penicillin [1406-05-9], streptomycin [57-92-1], erythromycin [114-07-8], tetracycline [60-54-8], oxytetracycline [79-57-2], chlortetracycline [57-62-5], and levomycetin [56-75-7].

Mikrobiologichnii Zhurnal (1934-1977) published new progress about 38146-42-8. 38146-42-8 belongs to chlorides-buliding-blocks, auxiliary class Achiral Phase-Transfer Catalysts, name is N1,N10-Bis(2-((2-isopropyl-5-methylcyclohexyl)oxy)-2-oxoethyl)-N1,N1,N10,N10-tetramethyldecane-1,10-diaminium chloride, and the molecular formula is C38H74Cl2N2O4, Category: chlorides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Sahu, Meeta published the artcileDesign, synthesis and evaluation of newer 5,6-dihydropyrimidine-2(1H)-thiones as GABA-AT inhibitors for anticonvulsant potential, Synthetic Route of 3696-23-9, the publication is Bioorganic Chemistry (2017), 166-178, database is CAplus and MEDLINE.

Several new 5,6-dihydropyrimidine-2(1H)-thione derivatives have been prepared and investigated for their potencies for anticonvulsant activity against maximal electroshock (MES) and s.c. pentylenetetrazole (scPTZ) test in mice. The acute neurotoxicity was measured by rotarod test. Compounds 3c (1-(4-methoxyphenyl)-4,6-diphenyl-5,6-dihydropyrimidine-2(1H)-thione) and 3l (4-(4-hydroxyphenyl)-1-(2-nitrophenyl)-6-phenyl-5,6-dihydropyrimidine-2(1H)-thione) were found active in both of the animal models. Further, in vitro GABA-AT enzyme activity assay was carried out to investigate the possible mechanism of action through GABA-AT inhibition. The most potent compounds 3c and 3l showed inhibitory potency (IC₅₀) of 18.42 μM and 19.23 μM, resp. The mol. modeling was performed for all the synthesized compounds The docking results were found in concordant with the observed animal studies.

Bioorganic Chemistry published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Synthetic Route of 3696-23-9.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Aukland, Miles H. published the artcileMetal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, the publication is Nature Catalysis (2020), 3(2), 163-169, database is CAplus.

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance.

Nature Catalysis published new progress about 637-07-0. 637-07-0 belongs to chlorides-buliding-blocks, auxiliary class Inhibitor,Cell Cycle,PPAR, name is Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate, and the molecular formula is C12H15ClO3, Application of Ethyl 2-(4-chlorophenoxy)-2-methylpropanoate.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Li, Shan published the artcileDiscovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant, COA of Formula: C6H3ClFNO2, the publication is Journal of Medicinal Chemistry (2022), 65(15), 10674-10690, database is CAplus and MEDLINE.

Janus kinase 3 (JAK3) is a potential target for the treatment of hematol. malignancies. Herein, we report the discovery of a series of new orally bioavailable irreversible JAK3 kinase inhibitors. The representative compound 12n (I) potently inhibited JAK3 kinase activity with an IC₅₀ value of 1.2 nM and was more than 900-fold selective over JAK1, JAK2, and Tyk2. Cell-based assays revealed that 12n significantly suppressed phosphorylation of JAK3 and the downstream effectors STAT3/5 and also robustly restrained proliferation of BaF3 cells transfected with JAK3^M511I activating mutation and human leukemia U937 cells harboring JAK3^M511I with IC₅₀ values of 22.9 and 20.2 nM, resp. More importantly, 12n showed reasonable pharmacokinetic (PK) properties, and oral administration of 12n at a dose of 50 mg/kg twice daily led to tumor regression in a U937 cell inoculated xenograft mouse model. Thus, 12n represents a promising lead compound for further optimization to discover new therapeutic agents for hematol. malignancies.

Journal of Medicinal Chemistry published new progress about 350-30-1. 350-30-1 belongs to chlorides-buliding-blocks, auxiliary class Fluoride,Chloride,Nitro Compound,Benzene, name is 3-Chloro-4-fluoronitrobenzene, and the molecular formula is C6H3ClFNO2, COA of Formula: C6H3ClFNO2.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Nishad, Ravi K. published the artcileDesign and Synthesis of 2-Substituted Benzothiazole Derivatives as Antioxidant and Antimicrobial Agents, Application of 1-(4-Chlorophenyl)thiourea, the publication is Current Bioactive Compounds (2020), 16(8), 1242-1248, database is CAplus.

An upsurge in the number of antibiotic-resistant microbial infections has warranted the discovery and development of new antibiotics. This is a matter of great concern for effective therapy for a search of novel antimicrobial agents. Literature has a number of reports of involvement of oxidative stress due to an imbalance between the generation and neutralization of free radicals in many diseases. Heterocyclic compounds have been involved in the treatment of various disorders. Benzothiazole is one such heterocyclic nucleus having benzene ring merged with the thiazole ring. Among the various substitutions possible in this nucleus, substitutions at position-2 have already been reported with potential bioactivities. Thus, different substituted compounds have been synthesized which could serve as antimicrobials and antioxidants. Benzothiazole derivatives (B₁-B₇) were synthesized by two-step reactions and the structures were confirmed through IR, mass and NMR spectroscopy. The compounds were evaluated for in vitro antioxidant and antimicrobial activities using standard methods. The results of antibacterial and antifungal activity showed that compound B₄ exhibited maximum activity against all the tested strains of microorganisms with the zone of inhibition 17.1-18.5 mm and MIC value 1.1-1.5μg/mL. Compound B₅ exhibited potent antioxidant activity. The compounds substituted with halogen on the aryl ring showed increased antimicrobial activity as seen in the case of compound B₄ (6-fluoro). The compounds substituted with a hydroxyl group (B₅) exhibited good antioxidant activity.

Current Bioactive Compounds published new progress about 3696-23-9. 3696-23-9 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Thiourea,Amine,Benzene,Amide, name is 1-(4-Chlorophenyl)thiourea, and the molecular formula is C7H7ClN2S, Application of 1-(4-Chlorophenyl)thiourea.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics

Lugovoi, Yu. M. published the artcileKinetics of competitive addition of methyldichlorosilane to 1-hexene and to acetone, HPLC of Formula: 14799-94-1, the publication is Reaction Kinetics and Catalysis Letters (1989), 39(2), 379-85, database is CAplus.

The competitive addition of MeSiHCl₂ to 1-hexene and acetone (initiated by γ-irradiation) has been studied. The relative rate constant depends on acetone concentration and does not obey the Arrhenius equation. A possible explanation is the complexation of methyldichlorosilyl radicals with acetone mols.

Reaction Kinetics and Catalysis Letters published new progress about 14799-94-1. 14799-94-1 belongs to chlorides-buliding-blocks, auxiliary class Aliphatic Chain, name is Dichloro(hexyl)(methyl)silane, and the molecular formula is C7H16Cl2Si, HPLC of Formula: 14799-94-1.

Referemce:
https://en.wikipedia.org/wiki/Chloride,
Chlorides – an overview | ScienceDirect Topics