Novel indanyl-substituted imidazo[1,2-a]pyridines as potent reversible inhibitors of the gastric H+/K+-ATPase was written by Zimmermann, Peter Jan;Buhr, Wilm;Brehm, Christof;Palmer, Andreas Marc;Feth, Martin Philipp;Senn-Bilfinger, Joerg;Simon, Wolfgang-Alexander. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Product Details of 59237-53-5 This article mentions the following:
A series of novel 8-indanylamino- and 8-indanyloxy-substituted imidazo[1,2-a]pyridines with reduced lipophilicity was synthesized from easily accessible starting compounds The anti-secretory activity of these compounds has been assessed in a competitive binding assay against H+/K+-ATPase from hog gastric mucosa. Some of the compounds proved to be potent inhibitors of the gastric acid pump. In the experiment, the researchers used many compounds, for example, Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5Product Details of 59237-53-5).
Methyl 6-chloro-5-nitronicotinate (cas: 59237-53-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Product Details of 59237-53-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics