Discovery and optimization of N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamides as novel GPR119 agonists was written by Yu, Ming;Zhang, Jian;Wang, Yingcai;Zhu, Jiang;Kayser, Frank;Medina, Julio C.;Siegler, Karen;Conn, Marion;Shan, Bei;Grillo, Mark P.;Coward, Peter;Liu, Jiwen. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.SDS of cas: 40108-12-1 This article mentions the following:
The discovery and optimization of novel N-(3-(1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-4-yloxy)phenyl)benzenesulfonamide GPR119 agonists is described. Modification of the pyridylphthalimide motif of the mol. with R1 = -Me and R2 = –iPr substituents, incorporated with a 6-fluoro substitution on the central Ph ring offered a potent and metabolically stable tool compound 22. In the experiment, the researchers used many compounds, for example, Ethyl-2-chloro-3-cyano-6-methylisonicotinate (cas: 40108-12-1SDS of cas: 40108-12-1).
Ethyl-2-chloro-3-cyano-6-methylisonicotinate (cas: 40108-12-1) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.SDS of cas: 40108-12-1
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics