Solid-Phase Synthesis of Chlorofusin Analogues was written by Woon, Esther C. Y.;Arcieri, Mariangela;Wilderspin, Andrew F.;Malkinson, John P.;Searcey, Mark. And the article was included in Journal of Organic Chemistry in 2007.Name: 5-Chloro-2-methoxybenzoic acid This article mentions the following:
The authors have efficiently synthesized two series of chlorofusin analogs, one bearing varying chromophores and the other with various amino acid substitutions in the cyclic peptide. These peptides were prepared via solid-phase methods using a strategy involving side-chain immobilization, on-resin cyclization, and postcyclization modification. The success of these syntheses demonstrates the broad utility of the method. Both series of analogs were evaluated for their inhibitory activity against the p53/MDM2 interaction but were shown to be inactive in the concentration range tested. This suggests that the full chromophore structure may be required for activity. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Name: 5-Chloro-2-methoxybenzoic acid).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Name: 5-Chloro-2-methoxybenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics