Synthesis and molecular docking study of piperazine derivatives as potent urease inhibitors was written by Taha, Muhammad;Wadood, Abdul. And the article was included in Bioorganic Chemistry in 2018.Recommanded Product: 2,4-Dichlorophenylisothiocyanate This article mentions the following:
Urease is known to be one of the major causes of diseases induced by Helicobacter pylori, thus allow them to survive at low pH inside the stomach and thereby, play an important role in the pathogenesis of gastric and peptic ulcer, apart from cancer as well. Keeping in view the great importance of urease inhibitors, here in this study the authors have synthesized piperazine derivatives (1-15) and evaluated for their urease inhibitory activity. All analogs showed excellent inhibitory potential with IC50 values ranging between 1.1±0.01 and 33.40±1.50 μM when compared with the standard inhibitor thiourea (IC50 = 21.30±1.10 μM). Structure activity relationship has been established for all compounds which are mainly based upon the substitution on Ph ring. Mol. docking study was performed to understand the binding interaction of the compounds in the active site of enzyme. In the experiment, the researchers used many compounds, for example, 2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1Recommanded Product: 2,4-Dichlorophenylisothiocyanate).
2,4-Dichlorophenylisothiocyanate (cas: 6590-96-1) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 2,4-Dichlorophenylisothiocyanate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics