Discovery of BAZ2A bromodomain ligands was written by Spiliotopoulos, Dimitrios;Wamhoff, Eike-Christian;Lolli, Graziano;Rademacher, Christoph;Caflisch, Amedeo. And the article was included in European Journal of Medicinal Chemistry in 2017.Related Products of 39489-79-7 This article mentions the following:
The bromodomain adjacent to zinc finger domain protein 2A (BAZ2A) is implicated in aggressive prostate cancer. The BAZ2A bromodomain is a challenging target because of the shallow pocket of its natural ligand, the acetylated side chain of lysine. Here, we report the successful screening of a library of nearly 1500 small mols. by high-throughput docking and force field-based binding-energy evaluation. For seven of the 20 mols. selected in silico, evidence of binding to the BAZ2A bromodomain is provided by ligand-observed NMR spectroscopy. Two of these compounds show a favorable ligand efficiency of 0.42 kcal/mol per non-hydrogen atom in a competition-binding assay. The crystal structures of the BAZ2A bromodomain in complex with four fragment hits validate the predicted binding modes. The binding modes of compounds 1 and 3 are compatible with ligand growing for optimization of affinity for BAZ2A and selectivity against the close homolog BAZ2B. In the experiment, the researchers used many compounds, for example, 5-Amino-2,4-dichlorophenol (cas: 39489-79-7Related Products of 39489-79-7).
5-Amino-2,4-dichlorophenol (cas: 39489-79-7) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Related Products of 39489-79-7
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics