Synthesis and antitumor activity of bis(arylsulfonyl)dihydroimidazolinone derivatives was written by Sittihan, Satapanawat;Jumpathong, Watthanachai;Sopha, Pattarawut;Ruchirawat, Somsak. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020.Recommanded Product: 777-44-6 This article mentions the following:
A series of novel bis(arylsulfonyl)dihydroimidazolinones with different aryl substitution patterns, I (Ar = 4-MeC6H4, 2-naphthyl, 2,6-F2C6H3, 8-quinolinyl, etc.) were readily synthesized and evaluated for their antitumor activities. Some of the newly synthesized compounds exhibited cytotoxicity at micromolar range against multiple cancer cell lines, including A549, HepG2, HuCCA-1, and MOLT-3. The most potent analog contained pentafluorobenzenesulfonyl groups, which could be chem. elaborated to serve as a potential pharmacophore. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Recommanded Product: 777-44-6).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Recommanded Product: 777-44-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics