Efficient copper-catalyzed synthesis of 2-arylbenzimidazole derivatives by reaction of 1-fluoro-2-nitrobenzene with benzamidine hydrochlorides was written by Sayahi, Mohammad Hosein;Khoshneviszadeh, Mehdi;Soheilizad, Mehdi;Saghanezhad, Seyyed Jafar;Mahdavi, Mohammad. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2018.Reference of 18637-02-0 This article mentions the following:
A novel and efficient approach to the preparation of 2-arylbenzimidazoles is described. Heating a mixture of 1-fluoro-2-nitrobenzene and benzamidine hydrochlorides in the presence of CuBr and K2CO3 in DMSO afforded 2-arylbenzimidazoles in good to excellent yields. The reaction was initiated by nucleophilic aromatic substitution and further proceeded by intramol. nucleophilic copper-catalyzed cyclization reaction of benzamidine. In the experiment, the researchers used many compounds, for example, 2-Chloro-benzamidine hydrochloride (cas: 18637-02-0Reference of 18637-02-0).
2-Chloro-benzamidine hydrochloride (cas: 18637-02-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Reference of 18637-02-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics