A new class of potent nonpeptide luteinizing hormone-releasing hormone (LHRH) antagonists: design and synthesis of 2-phenylimidazo[1,2-a]pyrimidin-5-ones was written by Sasaki, Satoshi;Imaeda, Toshihiro;Hayase, Yoji;Shimizu, Yoshiaki;Kasai, Shizuo;Cho, Nobuo;Harada, Masataka;Suzuki, Nobuhiro;Furuya, Shuichi;Fujino, Masahiko. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2002.Reference of 697-73-4 This article mentions the following:
The design and synthesis of a new class of nonpeptide LH-releasing hormone (LHRH) receptor antagonists, the 2-phenylimidazo[1,2-a]pyrimidin-5-ones, is reported. Among compounds described in this study, we identified a potent antagonist with nanomolar in vitro functional antagonism. The result might suggest that the heterocyclic 5-6-ring system possessing a pendant Ph group attached to the five-membered ring is the important structural feature for a scaffold of small mol. LHRH antagonists. In the experiment, the researchers used many compounds, for example, 2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4Reference of 697-73-4).
2-(Chloromethyl)-1,3-difluorobenzene (cas: 697-73-4) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Reference of 697-73-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics