Design and synthesis of conformationally constraint Dyrk1A inhibitors by creating an intramolecular H-bond involving a benzothiazole core was written by Salah, Mohamed;Abdel-Halim, Mohammad;Engel, Matthias. And the article was included in MedChemComm in 2018.Safety of 2-(3-Methoxyphenyl)acetyl chloride This article mentions the following:
The development of conformationally pre-organised Dyrk1A inhibitors based on the hydroxybenzothiazole urea I (X = NH, O, CH2; R1 = H, 3-OH, CONHC6H5), II (X = NH, O, CH2; Y = C6H5, 3-CH3OC6H4, 4-COOHC6H4, etc.) scaffold is presented. The modifications introduced to the discovered hit (AHS-211) proved the crucial role of the urea linker to preserve the bioactive conformation and led to the development of compound I (X = NH; R1 = 4-methylpiperazinylcarbonyl), as a promising selective Dyrk1A inhibitor. In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0Safety of 2-(3-Methoxyphenyl)acetyl chloride).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of 2-(3-Methoxyphenyl)acetyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics