PEPPSI-type 2-methyl-2-propenyl-functionalized N-heterocyclic carbene-palladium complexes: Synthesis, structural characterization and catalytic activity on Suzuki-Miyaura reaction was written by Sahin, Neslihan. And the article was included in Journal of Molecular Structure in 2019.Quality Control of 1-(Chloromethyl)-3-methylbenzene This article mentions the following:
N-Heterocyclic carbenes (NHCs) have been known to be efficient ligands for the Suzuki-Miyaura cross-coupling. In this work, four novel 2-methyl-2-propenyl substituted N-heterocyclic carbene ligands were synthesized. They were used to produce four novel air-stable PEPPSI-type palladium-NHC complexes I (R = Bn, 3-MeC6H4CH2, 1-naphthylmethyl, 9-anthrylmethyl). In addition, prepared complexes I were investigated as catalysts in the Suzuki-Miyaura coupling reaction under very mild conditions using a mixture of i-PrOH/water as a solvent and a base at the room temperature Under optimal reaction conditions, the expected biaryl products were obtained in moderate to high yields. In the experiment, the researchers used many compounds, for example, 1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9Quality Control of 1-(Chloromethyl)-3-methylbenzene).
1-(Chloromethyl)-3-methylbenzene (cas: 620-19-9) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Quality Control of 1-(Chloromethyl)-3-methylbenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics