Preparation of some new substituted phenylglyoxals was written by Nardi, Dante;Tajana, Alberto;Massarani, Elena. And the article was included in Annali di Chimica (Rome, Italy) in 1969.Recommanded Product: 5344-49-0 This article mentions the following:
ArCOCHO (I) are prepared by 3 different methods. II are prepared from I and o-(H2N)2C6H4; ArCOCO2H are treated with o-(H2N)2C6H4 to give III. Thus, a mixture of 15 g o-MeOC6H4Ac, 13.32 g SeO2, 50 ml HOAc, and 10 ml H2O is refluxed 5 hr to give 50% o-methoxyphenylglyoxal, b0.1 81°. Similarly prepared are the following I (Ar and b.p./mm given): o-ClC6H4, 92°/l; m-ClC6H4, 90°/1.5 (hydrate m. 82-4°); 4,2-Cl(O2N)C6H3, 118°/0.4; 5,2-Cl(O2N)C6H3, 128°/0.6; 2,4-Cl(O2N)C6H3, 118°/0.5 (hemihydrate m. 88°); 2,5-Cl(O2N)-C6H3, 137°/0.8 (hydrate m. 91-3°); 4,3-Cl(O2N)C6H3, 134°/-0.6. IV are treated with HCl to give 5,2-Cl(O2N)C6H3COCHO and 4,2-Cl(O2N)C6H3COCHO. 2-Chlor-6-nitro-ω-diazoacetophenone (0.03 mole) is treated with 0.031 mole Ph3P to give 2,6-Cl(O2N)C6H3CH:NN:PPh3, m. 182°, which (4.87 g) is treated with 1.52 g NaNO2, 18 ml 2M HCl, and 3.9 g PhNHCH2CH2NHPh to give V [Ar = 2,6-Cl(O2N)C6H3] (VI), m. 151-2°. Similarly prepared are 2,4-Cl(O2N)C6H3CH:NN:PPh3, m. 162°, and V [Ar = 2,4-Cl(O2N)C6H3], m. 145-6°. VI (2.03 g) is treated with 6 ml HCl (d. 1.18) to give 30% 2,6-Cl(O2N)C6H3-COCHO, b0.3 110°; hydrate m. 102-4°. Similarly prepared is I [Ar = 2,4-Cl(O2N)C6H3]. Also prepared are the following II and III (Ar, m.p. II, and m.p. III given): o-MeOC6H4, 110°, 230°; o-ClC6H4, 94-5°, 237°; 4,2-Cl(O2N)C6H3, 195°, 322°; 5,2-Cl(O2N)C6H3, 166-7°, 306°; 2,4-Cl(O2N)C6H3, 175°, 313°; 2,5-Cl(O2N)C6H3, 216°, 324-5°; 4,3-Cl(O2N)C6H3, 187-8°, 298°. Also the following II (Ar and m.p. given): m-ClC6H4, 130°; 2,6-Cl(O2N)C6H3, 121-2°. Also the following III (Ar and m.p. given): M-MeOC6H4, 183°; m-O2NC6H3, 328-9°; p-O2NC6H4, 350°. Also the following IV (Ar and m.p. given): m-ClC6H4, 184°; 2,4-Cl(O2N)C6H3, 231°; 5,2-Cl(O2N)C6H3, 199-201°; 4,3-Cl(O2N)C6H3, 190°. Also the following compounds: 2,6-Cl-(O2N)C6H3COCHAcCO2Et (m. 68-9°), 2,6-Cl(O2N)C6H3Ac (m. 60°), 2,6-Cl(O2N)C6H3COCH2Ac (m. 85°), 2,4-Cl(O2N)C6H3Ac 4,2-Cl(O2N)C6H3Ac. In the experiment, the researchers used many compounds, for example, 2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0Recommanded Product: 5344-49-0).
2-Chloro-6-nitrobenzoic acid (cas: 5344-49-0) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Recommanded Product: 5344-49-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics