Design, Synthesis, and Biological Evaluation of Tetrahydro-β-carboline Derivatives as Selective Sub-Nanomolar Gelatinase Inhibitors was written by Mangiatordi, Giuseppe Felice;Guzzo, Tatiana;Rossano, Eugenio Claudio;Trisciuzzi, Daniela;Alberga, Domenico;Fasciglione, Giovanni;Coletta, Massimiliano;Topai, Alessandra;Nicolotti, Orazio. And the article was included in ChemMedChem in 2018.Name: 4-Butoxybenzene-1-sulfonyl chloride This article mentions the following:
Targeting matrix metalloproteinases (MMPs) is a pursued strategy for treating several pathol. conditions, such as multiple sclerosis and cancer. Herein, a series of novel tetrahydro-β-carboline derivatives with outstanding inhibitory activity toward MMPs are present. In particular, compounds 9f, 9g, 9h and 9i show sub-nanomolar IC50 values. Interestingly, compounds 9g and 9i also provide remarkable selectivity toward gelatinases; IC50=0.15 nM for both toward MMP-2 and IC50=0.63 and 0.58 nM, resp., toward MMP-9. Mol. docking simulations, performed by employing quantum mechanics based partial charges, shed light on the rationale behind binding involving specific interactions with key residues of S1′ and S3′ domains. Taken together, these studies indicate that tetrahydro-β-carboline represents a promising scaffold for the design of novel inhibitors able to target MMPs and selectively bias gelatinases, over the desirable range of the pharmacokinetics spectrum. In the experiment, the researchers used many compounds, for example, 4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3Name: 4-Butoxybenzene-1-sulfonyl chloride).
4-Butoxybenzene-1-sulfonyl chloride (cas: 1138-56-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 4-Butoxybenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics