Pyrrolobenzodiazepines with antinociceptive activity: synthesis and pharmacological activities was written by Mai, A.;Di Santo, R.;Massa, S.;Artico, M.;Pantaleoni, G. C.;Giorgi, R.;Coppolino, M. F.;Barracchini, A.. And the article was included in European Journal of Medicinal Chemistry in 1995.COA of Formula: C9H9ClO2 This article mentions the following:
The synthesis of some N-[2-(1H-pyrrol-1-yl)benzyl]arylacetamides and 4-(arylmethyl)-5,6-dihydro-4H-pyrrolo[1,2-a]-[1,4]benzodiazepines as their conformationally restricted analogs was reported. The reduction of arylacetamides and N-methylation of pyrrolobenzodiazepines led to the corresponding N-[2-(1H-pyrrol-1-yl)benzyl]arylehylamines and the 4-(arylmethyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepines, resp. The new compounds were subjected to pharmacol. tests for evaluation of antinociceptive effects. Neuro-behavioral assays was also carried out on selected compounds to acquire data on neurotoxicity. One of the most active compounds was 4-(4-methoxybenzyl)-5-methyl-5,6-dihydro-4H-pyrrolo[1,2-a][1,4]benzodiazepine; it showed high activity in both hot-plate and acetic-acid-induced writhing tests in mice without sedative or myorelaxant effects . In the experiment, the researchers used many compounds, for example, 2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0COA of Formula: C9H9ClO2).
2-(3-Methoxyphenyl)acetyl chloride (cas: 6834-42-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C9H9ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics