Synthesis, molecular docking and biological evaluation of quinolone derivatives as novel anticancer agents was written by Li, Jie;Zheng, Tu-cai;Jin, Yi;Xu, Jian-guo;Yu, Jian-gang;Lv, Yan-wen. And the article was included in Chemical & Pharmaceutical Bulletin in 2018.Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride This article mentions the following:
A series of novel quinolone derivatives (8a-j) I (R1 = 4-F, 2,4-diF; R2 = 4-CH3, 2-Cl, 2,6-diCl, 2-CF3, 3-CF3) were synthesized, and their anticancer activities were 1 tested in human cancer cell lines, human lung carcinoma cell (A549), human promyelocytic leukemia cell (HL-60), and human cervical cancer cell (Hela). Compound 8i I (R1 = 2,4-diF; R2 = 2-CF3) was found to be 5-times more potent in cell- killing activity for cell Iines A549, HL-60, and Hela than the pos. control irinotecan or cisplatin, with IC50 of 0.009, 0.008 and 0.010μm, resp. The docking study revealed that compound 8i might have strong interactions with the active site of DNA-topoisomerase I. In the experiment, the researchers used many compounds, for example, 3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride).
3-(Trifluoromethyl)benzene-1-sulfonyl chloride (cas: 777-44-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Name: 3-(Trifluoromethyl)benzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics