Mannich reaction. N-[2-Hydroxy-3 (or 5 or 6)-substituted] benzyl glycines was written by Kumar, Kishan;Pandey, N. D.;Mehrotra, J. K.. And the article was included in Journal of the Indian Chemical Society in 1974.Recommanded Product: 3438-16-2 This article mentions the following:
Mannich reaction of glycine and HCHO with substituted phenols gave 35-65% I (R1 = H; R2, R3, R4 = H, Me, Cl, CO2H), which were methylated with Me2SO to give 50-96% of the corresponding I (R1 = Me). Thus, glycine, HCHO, and PhOH in NaOAc and HOAc gave 38.67% I (R1-R4 = H), which was methylated with Me2SO4 in NaOH at 80° to give 60.97% Me2SO4 (R1 = Me, R2-R4 =H). In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2Recommanded Product: 3438-16-2).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 3438-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics