Palladium-Catalyzed meta-Selective C-H Alkenylation and Acetoxylation of Arylacetic Acid Using a Pyrimidine Template was written by Jiao, Bo;Peng, Zhen;Dai, Zhen-Hua;Li, Lei;Wang, He;Zhou, Ming-Dong. And the article was included in European Journal of Organic Chemistry in 2019.Application In Synthesis of 2,5-Difluorophenylacetyl chloride This article mentions the following:
In the presence of Pd(OAc)2 and N-acetylglycine, pyrimidinylphenyl esters of arylacetic acids such as I underwent regioselective meta-selective alkenylation reactions with electron-deficient alkenes such as Et acrylate mediated by Ag2CO3 in hexafluoroisopropanol to yield alkenylarylacetate esters such as II. Using PhI(OAc)2 as oxidant and Ac2O, four of the pyrimidinylphenyl esters underwent regioselective acetoxylation to yield acetoxyphenylacetates. The pyrimidinylphenyl moiety was readily removable from the products and recovered. In the experiment, the researchers used many compounds, for example, 2,5-Difluorophenylacetyl chloride (cas: 157033-23-3Application In Synthesis of 2,5-Difluorophenylacetyl chloride).
2,5-Difluorophenylacetyl chloride (cas: 157033-23-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application In Synthesis of 2,5-Difluorophenylacetyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics