Synthesis and neuroleptic activity of benzamides. cis-N-(1-Benzyl-2-methylpyrrolidin-3-yl)-5-chloro-2-methoxy-4-(methylamino)benzamide and related compounds was written by Iwanami, Sumio;Takashima, Mutsuo;Hirata, Yasufumi;Hasegawa, Osamu;Usuda, Shinji. And the article was included in Journal of Medicinal Chemistry in 1981.HPLC of Formula: 3438-16-2 This article mentions the following:
Fifty-two benzamides were designed and synthesized as potential neuroleptics and were evaluated for their inhibitory effects on apomorphine-induced stereotyped behavior in rats. In the metoclopramide analog (linear benzamides) series, N[2-(N-benzyl-N-methylamino)ethyl]-5-chloro-2-methoxy-4-(methylamino)benzamide-HCl (I) [61694-55-1] was ∼15 times more active than metoclopramide itself. In a cyclic series (benzamides of 1-benzyl-3-aminopyrrolidine), most compounds tested were more active than corresponding linear benzamides. YM-09151-2 (II) [75272-39-8] was the most active compound of all the compounds tested, but it had a high antistereotypic activity-to-cateleptogenicity ratio compared with haloperidol and metoclopramide. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2HPLC of Formula: 3438-16-2).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 3438-16-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics