Synthesis and Anti-Inflammatory Activities of Some New Substituted Benzocarboxamide Pyrimidine Derivatives Using N-(4-acetylphenyl)-5-chloro-2-methoxybenzamide as Starting Material was written by Hussain, Azza A.;Abdulla, Mohamed M.;Amr, Abd El-Galil;Al-Omar, Mohamed A.;Shalaby, Ahmed F. A.. And the article was included in Asian Journal of Chemistry in 2014.COA of Formula: C8H7ClO3 This article mentions the following:
A series of substituted pyrimidine derivatives I (X = NH, O, S; Y = H, 2-Cl, 4-Cl, 4-Br, 2-NO2, 4-NO2, 4-OCH3) and II (Y = H, 2-Cl, 4-Cl, 4-Br, 2-NO2, 4-NO2, 4-OCH3) were prepared from corresponding chalcones III (Y = H, 2-Cl, 4-Cl, 4-Br, 2-NO2, 4-NO2, 4-OCH3), which were prepared from N-(4-acetylphenyl)-5-chloro-2-methoxybenzamide as starting material. The pharmacol. screening showed that many of these compounds have less toxicity and good anti-inflammatory activities. In the experiment, the researchers used many compounds, for example, 5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2COA of Formula: C8H7ClO3).
5-Chloro-2-methoxybenzoic acid (cas: 3438-16-2) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.COA of Formula: C8H7ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics