Gallou, Fabrice et al. published their research in Synlett in 2004 | CAS: 16588-16-2

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 16588-16-2

A practical synthesis of 2-aryl-indole-6-carboxylic acids was written by Gallou, Fabrice;Yee, Nathan;Qiu, Fenghe;Senanayake, Chris;Linz, Guenter;Schnaubelt, Juergen;Soyka, Rainer. And the article was included in Synlett in 2004.Recommanded Product: 16588-16-2 This article mentions the following:

A practical synthesis of 2-aryl-indole-6-carboxylic acids was developed via a sequence consisting of SNAr reaction, reductive cyclization, hydrolysis and decarboxylation. This process is efficient in terms of operational simplicity, cost effectiveness and is amenable to large scale production In the experiment, the researchers used many compounds, for example, Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2Recommanded Product: 16588-16-2).

Ethyl 4-chloro-3-nitrobenzoate (cas: 16588-16-2) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 16588-16-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics