Cyclizations of Substituted Benzylidene-3-alkenylamines: Synthesis of the Tricyclic Core of the Martinellines was written by Frank, Kristine E.;Aube, Jeffrey. And the article was included in Journal of Organic Chemistry in 2000.Category: chlorides-buliding-blocks This article mentions the following:
The martinellines are natural products that possess both interesting biol. activity and chem. structure. During the investigation of a hetero Diels-Alder route to these mols., alternate Lewis acid-dependent cyclizations of (2′-amino-N’-tert-butoxycarbonyl-5′-chlorobenzylidene)-3-butenylamine were observed The reaction of a variety of imines with TMSOTf or TiCl4 led to the formation of different heterocycles including iminodibenzo[b,f][1,5]diazocines, hexahydropyrido[1,2-c]quinazolin-6-ones, tetrahydropyrrolo[1,2-c]quinazolin-5-ones, 2-arylpiperidines, and 2-arylpyrrolidines. Tetrahydropyrrolo[1,2-c]quinazolin-5-one I, obtained via this new methodol., was used as an intermediate in the synthesis of the tricyclic ring system (II) of the martinellines. In the experiment, the researchers used many compounds, for example, tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6Category: chlorides-buliding-blocks).
tert-Butyl (4-chlorophenyl)carbamate (cas: 18437-66-6) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics